Person: EŞREFOĞLU, MUKADDES
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Publication Open Access Comparison of Small-diameter-hole and Traditional Microfracture in Cartilage Repair and the Effect of Adding a Hyaluronic Acid-based Acellular Matrix Scaffold: An Animal Study(2021-03-01T00:00:00Z) UÇAN, VAHDET; YILDIZ, FATİH; ELMADAĞ, Nuh Mehmet; UZER, GÖKÇER; GÜZEL, YUNUS; TOK, OLGU ENİS; Mukaddes, E.; UÇAN, VAHDET; YILDIZ, FATİH; ELMADAĞ, NUH MEHMET; UZER, GÖKÇER; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESObjective: Since, there is no standardized technique for the treatment of focal cartilage defects that can recreate original cartilage tissue; researchers continue to explore and evaluate various treatment modalities. This study compared post-operatke healing of cartilage defects after treatment with small-diameter-hole microfracture (SDHM) technique with that of traditional microfracture technique. The effects of the hole density and augmentation with hyaluronic acid-based acellular matrix (HA-based AM) on cartilage healing were also investigated. Methods: Articular cartilage defects measuring 5 mm in diameter and 3 mm in depth were created in each femoral trochlear groove of 21 New Zealand rabbits. Rabbits were assigned to seven groups comprising six knees each. The rabbits were sacrificed 12 weeks later, and the regenerated cartilage was harvested for histological evaluation using the Wakitani scoring system. Results: All defects were filled with regenerated tissue macroscopically. Group I (14; range 10-14 points) had significantly higher Wakitani score than in groups VI (6; range 1-11 points) and VII (5; range 3-10 points) (p=0.043 and p=0.016, respectively). No significant differences were observed among the other groups. Augmentation with HA-based AM did not contribute to cartilage healing. Conclusion: Improved cartilage healing was observed with increasing SDHM density than with traditional microfracture technique. SDHM combined with HA-based AM implantation did not improve the quality of the regenerated cartilage.Publication Metadata only Shea Yağının Yara İyileşmesi Üzerine Etkisi.(2016-05-03) BAYINDIR, NİHAN; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; Kılıç, Elif; BULUT, HURİ; BAYINDIR, NİHAN; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; BULUT, HURIPublication Metadata only Genç Ve Yaşlı Sprague-Dawley Sıçanlarda Parsiyel Hepatektomi Sonrası Melatoninin Karaciğer Rejenerasyonuna Etkisi.(2016-05-03) TOK, OLGU ENİS; AYDIN, M. S.; ESREFOGLU, MUKADDES; IRAZ, M.; KESKİN, Sıdıka; KOÇYİĞİT, ABDÜRRAHİM; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Uzun Süreli ve Düşük Doz Siklosporin Kullanımının Böbrek Dokusu Üzerine Apopitotik Etkileri(2014-03-09) Garip, Aylin; Uzak, Emirhan; TOK, OLGU ENİS; ESREFOGLU, MUKADDES; AKTAS, R. G.; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESPublication Metadata only Çörek Otu Yağının Sıçan Major Tükürük Bezlerinde ve Kan Parametrelerinde Radyoprotektif Etkileri(2016-10-30T00:00:00Z) Canpolat, Mustafa Salih; ŞAHİN YILMAZ, AYŞE ASLI; OYSU, ÇAĞATAY; GÜLER, ERAY METİN; SELEK, ŞAHBETTİN; Eriş, Ali Hikmet; MAYADAĞLI, ALPASLAN; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; GÜLER, ERAY METİN; SELEK, ŞAHABETTİN; MAYADAĞLI, ALPASLAN; EŞREFOĞLU, MUKADDESPublication Metadata only Effects of beta-glucan on protection of young and aged rats from renal ischemia and reperfusion injury(2016-01-01) ESREFOGLU, MUKADDES; Tok, OLGU ENİS; AYDIN, M. S.; OZER, O. F.; SELEK, S.; Iraz, M.; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİNBACKGROUND: Ischemia reperfusion injury is one of the leading causes of acute renal failure which is a common clinical event leading to development of chronic kidney disease and a high mortality; especially in elderly people. beta-glucans are glucose polymer groups with free-radical scavenger, macrophage activator, and immune defense inducer functions. We designed this study to determine the possible protective effects of beta-glucan against renal ischemia reperfusion injury comparatively in young and aged rats.Publication Metadata only Fluoxetine prevents ischemia perfusion induced acute cardiac inflammation and injury.(2016-08-25) Sahin, G.; Yaman, OM; Guner, I.; TOK, OLGU ENİS; Pala, M.; EŞREFOĞLU, MUKADDES; Yelmen, N.; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESPublication Metadata only Protective effect of beta-glucan on renal ischemia and reperfusion injury in young and aged rats.(2014-09-12) EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; AYDIN, M. S.; IRAZ, M.; SELEK, ŞAHBETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; SELEK, ŞAHABETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Remote Myocardial Injury: The Protective Role of Fluoxetine(2017-09-01) Yaman, Onur; Erman, Hayriye; Güner, İbrahim; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; Pala, Mukaddes; Gelisgen, Remise; Uzun, Hafize; Uğur, Aksu; Yelmen, Nermin; Şahin, Gülderen; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESPublication Metadata only Effects of Cichorium intybus on seizure development in pentyleneterazole kindling model of epilepsy(2015-05-03) ERKEC, OZLEM ERGUL; MERAL, İSMAİL; KARA, MEHMET; ESREFOGLU, MUKADDES; TOK, OLGU ENİS; MERAL, İSMAİL; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS