Person: EŞREFOĞLU, MUKADDES
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Publication Metadata only Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity.(2019-05-01) Esrefoglu, MUKADDES; Bayındır, NİHAN; KURBETLI, N; Selek, S; Akbas, Tosunoglu; Meydan, SEDAT; OZTURK, OSMAN; Bulut, HURİ; Meral, I; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; ÖZTÜRK, OSMAN; BAYINDIR, NİHAN; BULUT, HURI; MERAL, İSMAİLPublication Metadata only Melatonin and CAPE are able to prevent the liver from oxidative damage in rats: an ultrastructural and biochemical study.(2012-05-01) Esrefoglu, MUKADDES; IRAZ, M; ATES, B; GÜL, M; EŞREFOĞLU, MUKADDESPublication Metadata only Ascorbic acid and beta-carotene reduce stress-induced oxidative organ damage in rats.(2016-10-01) Esrefoglu, MUKADDES; AKINCI, A; TASLIDERE, ELİF; ELBE, H; CETIN, A; ATES, B; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİFPublication Open Access Antioxidant and toxicological in-vivo and in-vitro examination of licorice extract(2016-09-01) Bektay, MUHAMMED YUNUS; Uckaya, FATİH; Guler, E. M.; Bayindir, NİHAN; Kocyigit, ABDÜRRAHİM; Esrefoglu, MUKADDES; Topcu, GÜLAÇTI; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; GÜLER, ERAY METİN; BAYINDIR, NİHAN; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIPublication Metadata only Assessment of the effectiveness of cyclosporine nasal spray in an animal model of allergic rhinitis(2018-01-01) Senturk, EROL; Yildirim, YAVUZ SELİM; Dogan, REMZİ; Ozturan, ORHAN; Guler, ERAY METİN; AYDIN, Mehmet Serif; Kocyigit, ABDÜRRAHİM; Esrefoglu, MUKADDES; Kocak, Ilker; ŞENTÜRK, EROL; YILDIRIM, YAVUZ SELİM; DOĞAN, REMZI; ÖZTURAN, ORHAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDESThe aim of this study is to show if cyclosporine has an antiallergic role in a rat model of ovalbumin-induced allergic rhinitis. The 54 rats were divided into six equal groups. The first group was a negative control group without induced allergic rhinitis; the second group a positive control with induced allergic rhinitis not receiving treatment. The remaining four groups, after induction of allergic rhinitis, received intranasal cyclosporine treatment in doses of 0.05, 0.1, or 0.2% or nasal steroid treatment. In the biochemical examination, on the surface of the tissue tumor necrosis factor (TNF) interferon (IFN), interleukin (IL)-5, IL-13, as well as IL-2, IL-4, IL-17A, and IgE were studied. Histologically, ciliary loss, increase of goblet cells, vascular congestion, and the degree of eosinophil infiltration were rated. In all treatment groups, on average, a significant reduction in all histological and biochemical values was found compared to the positive control group. Comparing each of the three cyclosporine-using groups with the group of nasal corticosteroid did not show any significant difference in the average scores. Cyclosporine nasal drops are effective to be used in an animal model of experimental allergic rhinitis without systemic effects.Publication Metadata only Fluoxetine Attenuates Remote Myocardial Ischemia Reperfusion Injury(2017-09-01) Yaman, M. O.; Guner, I.; ERMAN, HAYRİYE; TOK, O. E.; Pala, M.; Esrefoglu, MUKADDES; Gelisgen, R.; Uzun, H.; Yelmen, N.; Sahin, G.; EŞREFOĞLU, MUKADDESPublication Metadata only The effects of pentoxifylline and caffeic acid phenethyl ester in the treatment of d-galactosamine-induced acute hepatitis in rats.(2016-04-01) TASLIDERE, ELİF; VARDI, N; Esrefoglu, MUKADDES; ATES, B; TASKAPAN, C; YOLOGLU, S; TAŞLIDERE, ELİF; EŞREFOĞLU, MUKADDESPublication Metadata only The protective effect of melatonin in lungs of newborn rats exposed to maternal nicotine.(2018-01-01) YILDIZ, A; VARDI, N; KARAASLAN, MG; ATES, B; TASLIDERE, ELİF; Esrefoglu, MUKADDES; TAŞLIDERE, ELİF; EŞREFOĞLU, MUKADDESPublication Open Access Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats(2016-12-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Bayindir, NİHAN; Iraz, Meryem; Ayhan, Siddika; Meydan, SEDAT; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; BAYINDIR, NİHAN; MEYDAN, SEDATObjective: We aimed to investigate the protective effects of curcumin (Cr) against cadmium (Cd) toxicity on the kidneys of both young and aged rats. Methods: Forty-eight young and aged female Spraque–Dawley rats were divided into control, Cd, Cr, and Cd+Cr groups. We investigated kidney damage using a histopathological scoring system and measured total antioxidant status (TAS) and total oxidant status (TOS) and interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels. Results: Kidney tissues of Cd groups showed acute histopathological alterations. Cr improved Cd-induced histopathological changes (p<0.05). The highest mean TAS was recorded in both the Cr groups. The highest mean TOS was recorded only in the aged Cd group. Cr decreased IL-6 levels in both the Cd+Cr groups (p<0.05). PCT levels in the Cd groups were higher than those in the control groups. Significance was detected only between the young Cd and control groups (p<0.05). PCT levels were reduced in both the Cd+Cr groups (p<0.05). CRP levels in the aged Cd group were higher than those in the other groups (p<0.05). Cr reduced CRP levels only in the aged Cd+Cr group (p<0.05). Conclusion: Our results suggest that Cr prevents Cd-induced renal oxidative damage in both young and aged rats.Publication Metadata only Therapeutic effects of Licorice (Glycyrrhiza glabra) on colitis through its antioxidant properties and biochemical analyses(2015-08-01) Uckaya, FATİH; Bektay, Yunus; Yilmaz, ANIL; Bayindir, NİHAN; Selek, ŞAHBETTİN; Topcu, GÜLAÇTI; Esrefoglu, MUKADDES; UÇKAYA, FATİH; BEKTAY, MUHAMMED YUNUS; YILMAZ, ANIL; BAYINDIR, NİHAN; SELEK, ŞAHABETTİN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES