Person: BULUT, HURI
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Publication Metadata only The effect of mesenchymal stem cell use on intra-abdominal adhesions in a rat model(2018-02-01T00:00:00Z) KARACA, GÖKHAN; PEHLİVANLI, FARUK; AYDIN, OKTAY; ALTUNKAYA, CANAN; UZUN, Hafize; Niyaz, Mehmet; Ozden, Huseyin; BULUT, Huri; BULUT, HURIPurpose: Intra-abdominal adhesions (IAA) are among the most frequently seen pathologies in general surgery practice with an increased morbidity and mortality. In the present study, we investigated the effect of locally applied mesenchymal stem cells (MSCs) on IAA.Publication Metadata only May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?(2019-09-01T00:00:00Z) AYDIN, OKTAY; PEHLİVANLI, FARUK; KARACA, GÖKHAN; AYDIN, GÜLÇİN; ALTUNKAYA, CANAN; BULUT, Huri; AYDINURAZ, KUZEY; BULUT, HURIBackground/Aims: Complete liver regeneration may not always be possible after liver injuries and/or partial liver resection. The present study investigated the effects of dexpanthenol, platelet-rich plasma (PRP), and thymoquinone on liver regeneration in rats after partial hepatectomy (PH).Publication Open Access Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10(2018-07-01T00:00:00Z) PEHLİVANLI, FARUK; AYDIN, OKTAY; KARACA, GÖKHAN; AYDIN, GÜLÇİN; DEVRİM, TUBA; BULUT, Huri; BAKAR, BÜLENT; DAPHAN, ÇAĞATAY ERDEN; BULUT, HURIBackground: In this study, the effectiveness of dexpanthenol and coenzyme Q10 (CoQ10) on the healing of ischemic colon anastomosis was investigated. Methods: Forty eight maleWistar Albino rats were divided into four equal groups (Sham-S, Sham-I, DXP, Q10). Following full layer colon resection, single layer colon anastomosis, without creating ischemia, was performed on the Sham-S group. The same experimental model was performed on remaining groups after ischemia was created. Intraperitoneal dexpanthenol and CoQ10 was administered to the DXP and Q10 groups once a day for three days. Ten days later, all colon anastomoses were investigated histopathologically and biochemically, as well as their burst pressure values, in all sacrificed rats. Results: The highest burst pressure value was observed in the Sham-S group, decreasing from high to low in the DXP, Q10, and Sham-I groups, respectively (p = 0.008). Furthermore, tissue hydroxyproline (p = 0.001) level values were significantly different among the groups. Additionally, histopathological analysis revealed a significant difference among groups regarding reepithelization (p = 0.027) and polymorphonuclear leukocyte density (p = 0.022). Conclusions: This preliminary study has shown that ischemia-reperfusion injury may impair the healing of colon anastomosis and it has been concluded that dexpanthenol and CoQ10 may have positive effects on the healing of ischemic colon anastomosis in rat, although re-epithelization may be adversely affected using CoQ10.