Person: TAŞLIDERE, BAHADIR
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Publication Metadata only Coexistence of Platypnea, Right Atrial Myxoma and Pulmonary Embolism(2019-03-24) TAŞLIDERE, BAHADIR; TAŞLIDERE, BAHADIRPublication Metadata only RELATIONSHIP BETWEEN SUICIDAL PATIENTS AND VITAMIN D(2019-04-25T00:00:00Z) Atik, Dilek; Taşlıdere, Bahadır; TAŞLIDERE, BAHADIRNTRODUCTION: When a person end their life consciously and intentionally, it is called suicide. Suicide is not a random and nonpurposeful movement, but it is a way of getting rid of the crisis or problem that cause a big trouble and can not be overcome (1,2).The person who committed suicide carries out this action with the thoughts of despair and the lack of people around to help. Suicide is related to ongoing stress factors and narrowing of options before the individual (1,2). The most commonly used method for suicide is multiple drug intake and suicide probability is high among people who have previously attempted suicide, people from families with suicidal individuals (3,4). One of the most investigated issues related to suicide is mental disorders. Numerous studies have reported high rates of mental disorders in individuals who attempt suicide or who die from suicide (5,6). In a study conducted on 100 people who had attempted suicide, 70% of them had depression, 15% had alcoholism, 3% had schizophrenia and 5% had other disorders (7). The most important of the sterols belonging to the vitamin D family is cholecalciferol (vitamin D3). Cholecalciferol is composed of 7- dehydrocholesterol in the skin with the effect of ultraviolet rays (8). The aim of this study was to investigate the vitamin D levels in patients admitted to our emergency department due to suicid intervention and to contribute to the treatment of clinical applications according to the results. METHOD: This study is conducted prospectively in patients presented with suicide in Istanbul Sağlık Bilimleri University Kanuni Sultan Suleyman Training and Research Hospital Emergency Medicine Clinic between 01.12.2018-01.02.2019 with the approval of Kanuni Sultan Süleyman Training and Research Hospital Ethics Committee by the protocol numbered 2018/11/47. The study included 59 individuals with suicidal attempt and 42 subjects with control group. Blood taken from the patients was taken as disposable 10 ml, vacuumed, nonanticoagulanted, in biochemistry tubes for 5-7 ml and centrifuged at 2500 rpm for 10 minutes and their serum was separated within half an hour. Separated serums were stored at -80°C until examined. Each serum was only dissolved once on the day of the study. All variables were tested for conformity to normal distribution, Kolmogorov Smirnov test and compliance with parametric test criteria. The data obtained by the study carried out within the scope of clinical research are statistically nonparametric. For this reason, Mann Whitney U tests were used for statistical evaluations based on categorical (nominal or ordinal) and binary variables. Spearman rank correlation in non-parametric data and Pearson correlation in parametric data were used as correlation methods. FINDINGS: A total of 59 patients and 42 control groups were included in our study. 70.3% (n = 71) of the participants were female and 29.7% (n = 30) were male. The mean age of the participants was 30.7 and the minimum and maximum ages were 18 and 53 years. When the final results of the patients were evaluated; 50.8% (n = 31) were discharged with health, 29.5% (n = 18) were hospitalized and 7.1% (n = 12) were admitted to intensive care unit. When the presence of psychiatric disease was evaluated inthe patients with suicidal attempt, 42.3% (n = 25) had psychiatric disease and 57.6% (n = 34) did not have a diagnosis of psychiatric disease. In patients with suicidal interventions, a positive, high level relationship was detected with the presence of psychiatric disease (r: 0.860, p=0.000). Hastaların The relationship between vitamin D levels and the presence of psychiatric disease was statistically significant (r: 0.276, p = 0.005). Laboratory parameters of vitamin D minimum 4.4 maximum 33 values were found, the effect of vitamin D on suicidal interference is negative, a significant relationship is found (z:-3.630, p=0.000). ). When the relationship between vitamin D levels and previous suicide attempts was found to be significant (z: -2.260, p = 0.024) DISCUSSION: It has been reported that vitamin D has an important role in the treatment of many chronic diseases in recent years (9,10). The risk of suicide is different in every psychiatric disorder. Psychiatric disorder most commonly associated with increased risk of suicide is major depression (11,12,13). The identification of vitamin D receptors in brain regions affecting depression has strengthened the relationship between vitamin D and depression. In human and animal studies, vitamin D receptors and 1-α-hydroxylase enzyme are found in the brain and the role of vitamin D in central nervous system functions have been shown (14,15). According to the results of our study, vitamin D levels was detected low in cases with sucidal attempts. There is increasing evidence that there is a relationship between depressive symptoms and low serum/plasma 25 (OH) D levels. Cross-sectional studies and prospective data also support that low vitamin D levels are associated with an increased risk of depression (16,17). In a study showing that vitamin D deficiency and mood disorders were very common among the elderly, the quality of life of the elderly women with low vitamin D (<400 IU / day) was found to be lower than those with higher vitamin D. In order to improve the quality of life in the elderly, it was emphasized that the recommended daily intake of vitamin D (≥400 IU / day) is important (18). In our study, the relationship between the presence of psychiatric disease in patients with suicidal attempt is indirectly similar to other studies. Low vitamin D levels were found to be a factor in suicidal intervention. CONCLUSION: Suicidal intervention is a condition with high mortality and morbidity. According to the results of our study, considering the low level of vitamin D in patients with suicidal interventions and underlying psychiatric disorders, it was thought that D vitamin replacement can be taken into treatment protocols and suicidal interventions could be reduced.Publication Metadata only ACIL SERVISTE RENAL VEN TROMBOZUNA YAKLAŞIM(2019-05-28) ÖZCAN, AYŞE BÜŞRA; SÖNMEZ, ERTAN; GÜLEN, BEDİA; TAŞLIDERE, BAHADIR; SAKIN, BEGÜM; METİN, HÜSEYİN; ÖZCAN, AYŞE BÜŞRA; SÖNMEZ, ERTAN; GÜLEN, BEDİA; TAŞLIDERE, BAHADIR; SAKIN, BEGÜM; METİN, HÜSEYİNPublication Metadata only Pnomoni güncel yaklaşım(2019-03-17) TAŞLIDERE, BAHADIR; TAŞLIDERE, BAHADIRPublication Metadata only Acil Serviste Gastroenteroloji Konsultasyonu İstenen Hastaların Analizi(2019-04-20) TAŞLIDERE, BAHADIR; TAŞLIDERE, BAHADIR; BİBERCİ KESKİN, ELMASPublication Metadata only ACIL SERVISTE İZOLE İNTERNÜKLEER OFTALMOPLEJI TANISI(2019-04-28) TAŞLIDERE, BAHADIR; GÜLEN, BEDİA; MEHMETAJ, LILJANA; SÖNMEZ, ERTAN; METİN, HÜSEYİN; TAŞLIDERE, BAHADIR; GÜLEN, BEDİA; MEHMETAJ, LILJANA; SÖNMEZ, ERTAN; METİN, HÜSEYİNPublication Metadata only İnvestigation of the Efficacy of Aminoguanidine in an Experimental Rat Model with Isolated Bilateral Pulmonary Contusion Due To Blunt Thoracic Trauma(2019-12-01T00:00:00Z) Atik, Dilek; Taşlıdere, Bahadır; TAŞLIDERE, BAHADIRİntroduction:In severe thoracic trauma pulmonary contusions are almost inevitable are associated with high morbidity and mortality. In this study we aimed to evaluate the antioxidant activity of aminoguanidine in pulmonary contusion.Method:Sixty-three Sprague-male rats were used. Sham and aminoguanidine groups were exposed to isolated blunt thoracic trauma with a force of 1,512 joules. Aminoguanidine was administered intraperitoneally at a dose of 100 mg/kg 3 hours before the trauma and on the 1. and 2. day after the trauma. The contusion group was exposed to blunt thoracic trauma only. In all groups, arterial blood gas analysis and catalase and NO levels were done on the 0th, 1st, 2nd and 3rd days.Results:PO2 levels were higher in the sham group compared to the contusion group, without statistical significance. On the third day, SaO2 levels were higher in the AG group compared to the contusion group. SaO2 levels were comparable in the AG and sham groups on days 1, 2 and 3. There was no difference between the PaO2 levels of the contusion and sham groups on the 2nd and 3rd days. There was no difference between the PaO2 levels of the AG and sham groups on the 1st, 2nd and 3rd days. We found no difference between the PaCO2 levels of the contusion and sham groups on the 0-3 days. There was no difference between the PaCO2 levels of the AG and sham groups on the 1st, 2nd and 3rd days. No difference was observed between the PaCO2 levels of the AG and contusion groups on the 1st, 2nd and 3rd days. No significant difference was found between the NO levels of the sham and the contusion groups on day 0. There was a significant difference between the sham and contusion groups on the 1st, 2nd and 3rd days. There was no statistically significant difference between the catalase enzyme activities of the sham and AG groups.Conclusion:In our study, we showed that the use of aminoguanidine did not significantly reduce the severity of pulmonary contusion and the inflammatory reaction induced by thoracic trauma in rats.Publication Metadata only hastane öncesi acil tıp ve paramedik(2019-03-01) TAŞLIDERE, BAHADIR; GÜLEN, BEDİA; TAŞLIDERE, BAHADIRPublication Metadata only Effects of melatonin on acetylsalicylic acid induced gastroduodenal and jejunal mucosal injury(2018-01-01T00:00:00Z) taslidere, elif; VARDI, NİGAR; PARLAKPINAR, HAKAN; YILDIZ, AHMET; Taslidere, BAHADIR; Karaaslan, M. G.; TAŞLIDERE, ELİF; TAŞLIDERE, BAHADIRWe evaluated the effects of melatonin on acetylsalicylic acid (ASA) induced gastroduodenal and jejunal mucosal injury. We used 40 postpubertal rats divided randomly into five groups of eight animals. The control group consisted of untreated animals. The Mel group was injected intraperitoneally (i.p.) with 5mg/kg melatonin. The ASA group was injected i.p. with 200mg/kg ASA. The ASA + Mel group was injected i.p. with 5mg/kg melatonin 45min after administering 200mg/kg ASA i.p. The Mel + ASA group was injected i.p. with 5mg/kg melatonin 45min before administering 200mg/kg ASA i.p. We found no statistically significant differences in mean histopathological scores in the ASA + Mel group compared to the ASA group. ASA caused shortened villi and loss of the apical villus in the duodenum. The histopathological score was increased and villus height was decreased in the ASA group compared to untreated controls. Treatment with melatonin attenuated the histological damage. In the ASA group, occasional areas showed erosion of villi in the jejunum; however, differences in mean histopathological score in ASA group compared to the other groups were not statistically significant. Malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) activities were measured in stomach, duodenal and jejunum tissue. We found increased MDA activity in both stomach and duodenal tissues in the ASA group compared to the control group (p<0.05). We found no statistically significant changes in MDA levels in jejunal tissue in the ASA group compared to the control group. We found no change in SOD activity in either stomach or duodenal tissues in the ASA group compared to the control group. We observed decreased SOD activity in jejunal tissue in the ASA group compared to the control group (p<0.05). We detected no change in GSH activity in stomach, duodenal or jejunal tissues in the ASA group compared to the control group. The stomach damage was less in melatonin treated groups, but the lesions were not completely eliminated. The jejunum in the ASA group retained a nearly normal appearance. We found that melatonin exhibited some healing effects on ASA induced duodenal mucosal injury.Publication Metadata only Acil Servislerde Geriatrik Hasta Yönetiminde Tuzaklar(2019-12-20) Taşlıdere, Bahadır; TAŞLIDERE, BAHADIR
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