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TAŞLIDERE, BAHADIR

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BAHADIR
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TAŞLIDERE
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End date: 2019 × Start date: 2016 × Rights: info:eu-repo/semantics/openAccess ×

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Now showing 1 - 5 of 5
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    İnvestigation of the Efficacy of Aminoguanidine in an Experimental Rat Model with Isolated Bilateral Pulmonary Contusion Due To Blunt Thoracic Trauma
    (2019-12-01T00:00:00Z) Atik, Dilek; Taşlıdere, Bahadır; TAŞLIDERE, BAHADIR
    İntroduction:In severe thoracic trauma pulmonary contusions are almost inevitable are associated with high morbidity and mortality. In this study we aimed to evaluate the antioxidant activity of aminoguanidine in pulmonary contusion.Method:Sixty-three Sprague-male rats were used. Sham and aminoguanidine groups were exposed to isolated blunt thoracic trauma with a force of 1,512 joules. Aminoguanidine was administered intraperitoneally at a dose of 100 mg/kg 3 hours before the trauma and on the 1. and 2. day after the trauma. The contusion group was exposed to blunt thoracic trauma only. In all groups, arterial blood gas analysis and catalase and NO levels were done on the 0th, 1st, 2nd and 3rd days.Results:PO2 levels were higher in the sham group compared to the contusion group, without statistical significance. On the third day, SaO2 levels were higher in the AG group compared to the contusion group. SaO2 levels were comparable in the AG and sham groups on days 1, 2 and 3. There was no difference between the PaO2 levels of the contusion and sham groups on the 2nd and 3rd days. There was no difference between the PaO2 levels of the AG and sham groups on the 1st, 2nd and 3rd days. We found no difference between the PaCO2 levels of the contusion and sham groups on the 0-3 days. There was no difference between the PaCO2 levels of the AG and sham groups on the 1st, 2nd and 3rd days. No difference was observed between the PaCO2 levels of the AG and contusion groups on the 1st, 2nd and 3rd days. No significant difference was found between the NO levels of the sham and the contusion groups on day 0. There was a significant difference between the sham and contusion groups on the 1st, 2nd and 3rd days. There was no statistically significant difference between the catalase enzyme activities of the sham and AG groups.Conclusion:In our study, we showed that the use of aminoguanidine did not significantly reduce the severity of pulmonary contusion and the inflammatory reaction induced by thoracic trauma in rats.
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    Arı Sokmasına Bağlı Akut Myokard İnfarktüsü: Kounis Sendromu
    (2019-02-01T00:00:00Z) Yakar, Şule; Baykan, Necmi; Taşlıdere, Bahadır; TAŞLIDERE, BAHADIR
    Arı sokmalarına bağlı lokal ve sistemik reaksiyonlar görülebilmektedir. Arı sokması sonrası nadiren görülen alerjik akut miyokart enfarktüsü; Kounis sendromu olarak tanımlanmıştır. Burada arı sokması sonrası acil servise getirilen ve akut miyokart enfarktüsü tanısı alan elli-beş yaş bir erkek olgu sunulmuştur.Acil servis hekimleri arı sokmasına bağlı gelişebilen Kounis sendromunu akılda tutmalı; göğüs ağrısı bulunan olgularda elektrokardiyografi çekmeli ve kardiyak enzim takibini mutlaka yapmalılardır.
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    Role of endothelial nitric oxide synthases system on acute appendicitis
    (2016-07-01) TASLIDERE, BAHADIR; ŞENER, Elif Funda; Taslidere, ELİF; GUNAY, Nahide Ekici; BOL, Oguzhan; BULBUL, Emre; Aktas, Ramazan Sami; GÜNAY, Nurullah; TAŞLIDERE, BAHADIR; TAŞLIDERE, ELİF
    BACKGROUND: Obstruction and inflammation of the appendix lumen is the leading physiopathological process during acute appendicitis (AA). Although the relationship between inflammation and endothelial nitric oxide synthases (eNOS) has been well described, no recent data describing the relationship between inflammation during AA and polymorphism of the eNOS gene has been reported. Given the limited data available, we believed that defining the relationship between AA and eNOS would be a beneficial contribution. METHODS: A total of 201 patients admitted to the emergency department with AA and 201 healthy volunteers selected from among the relatives of patients were included. Polymorphism of the eNOS was assessed. RESULTS: Intron 4a/4a was positive in 119 participants, genotype G894T GT was positive in 71 patients with AA, and 786-1 was positive in 71 patients with AA. These results suggest that no statistically significant correlation exists between genotypes of AA patients and control subjects regarding 4a/b, G894-GT, and 786-1 eNOS polymorphisms. CONCLUSION: Though the present results suggest that no statistically significant correlation exists between AA and eNOS gene polymorphism, to claim otherwise is also impractical. We believe that the present results will lay the groundwork for future, larger studies.
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    Can the Foot Pain Be the Varicella Zoster (Shingles)?
    (2019-09-01T00:00:00Z) Atik, Dilek; Taşlıdere, Bahadır; TAŞLIDERE, BAHADIR
    Shingles is one of the two different clinical presentations of infection of VZV which is a DNA virus. Humans are a known reservoir for the Varicella zoster virus (VZV). It is very contagious. The virus that remains latent after infection in childhood and can be reactive due to various reasons (immune system suppression, old age, stress factors, etc.). It involves various dermatomes after reactivation. Varicella-zoster appears mostly on thoracic, cervical, and ophthalmic dermatomes. Rarely, it is located in the upper and lower extremity dermatomes. In this study; 7 patients with shingles on the foot and sole were examined. It was aimed to emphasize that varicella zoster (zona) may be the cause of foot pain in patients presenting to the emergency department with complaints such as pain, burning and inability to step on standing, and to review the age, gender, underlying factors of the zona cases which are not previously mentioned in the literature
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    ACİL SERVİSE DERMATOLOJİK YAKINMALAR İLE BAŞVURAN HASTALARIN ANALİZİ
    (2019-12-01T00:00:00Z) Öztürk, Tayfun; Avşaroğulları, Levent; Taşlıdere, Bahadır; TAŞLIDERE, BAHADIR
    Amaç: Çalışmanın amacı Acil Servise dermatolojik yakınmalarla başvuran hastaların demografik ve klinik özellikleri, konsültasyon, taburculuk ve hastaneye yatış oranları ile hayati tehlike arz edebilecek klinik tabloları hakkında bilgi vermektir. Materyal ve Metot: Erciyes Üniversitesi Tıp Fakültesi Acil Servisi’ne dermatolojik şikâyetlerle başvuran hastalardan 16 yaş ve üzeri olanlar dâhil edilerek prospektif olarak yapılmıştır. Değerlendirmede yaş, cinsiyet, özgeçmiş, başvuru yakınması ve ortaya çıkış zamanı, hastaneye başvurana kadar geçen süre, lezyonun tipi, tanısı, konsültasyonlar, hastaneye yatış ve taburculuk durumunu içeren parametreler yer almıştır. Bulgular: Çalışmaya toplam 400 hasta dâhil edilmiştir. Acil Servise başvuran hastaların % 0,70’ini dermatolojik yakınmalar ile gelenler oluşturuyordu. Hastaların 221’i (%55) kadın olup yaş ortalaması 38,6 yıldı.. Ciltte kızarıklık % 29,8 oranı ile en sık başvuru nedeni ve ürtiker en çok tespit edilen tanıdır (%54,3). Hastaların %48,3’ünün yakınmalar başladıktan en az 24 saat sonra Acil Servise başvurmuştur. %31’i konsülte edilmiş olup en sık nedenler; selülit ve anjioödemdir. ‘Gerçek dermatolojik acil’ olarak nitelendirilen nekrotizan fasiit, toksik epidermal nekroliz, eritema multiforme birer hastada görülmüştür (%0.75). Hastaların %19’unun hastaneye yatırılmıştır ve en sık tanı selülittir (%30.8). Lezyon vücut yüzey alanının tek başına hastaneye yatış oranını etkilemediği görülmüştür. Sonuç: Dermatolojik yakınmalar ile başvuran hasta sayısının, tüm Acil Servis başvuruları içindeki oranı az olsa da özellikle yaşamı tehdit edebilecek sistemik organ etkilenmesi olan hastaların hastaneye yatırılarak tedavi edilmesi daha uygundur.