Person: ENHOŞ, ASIM
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Publication Metadata only Tam kan sayımında belirlenen nötrofil/lenfosit oranı pulmoner tromboemboli hastalarında mortalite belirteci olarak kullanılabilir mi?(2020-10-01T00:00:00Z) TURNA, FAHRETTİN; ENHOŞ, ASİM; ENHOŞ, ASIMPublication Open Access Impact of Antecedent Aspirin Use on Infarct Size, Bleeding and Composite Endpoint in Patients with de Novo Acute Myocardial Infarction(2021-01-01T00:00:00Z) ENHOŞ, Asim; KARAÇÖP, ERDEM; ENHOŞ, ASIM; KARAÇÖP, ERDEMBackground: The study aimed to evaluate the impact of antecedent aspirin use on infarct size, bleeding and composite endpoint in patients with de novo acute myocardial infarction. Patients and methods: A total of 562 consecutive patients with de novo acute myocardial infarction were included in this prospective cohort study. Patients were assigned into two groups based on presence (n=212) and absence (n=350) of prior aspirin use. Primary endpoint was myocardial infarct size, as estimated by troponin I peak. In-hospital mortality, bleeding and composite clinical endpoint including cardiogenic shock, stroke, in-hospital mortality and major bleeding were also evaluated. Results: Although GRACE and CRUSADE scores were higher, troponin I peak was lower in prior aspirin users. This result was maintained after adjustment for baseline ischemic risk profile and other major confounders including MI type and location. Despite high CRUSADE score, there was no increase in major and minor bleeding. Minimal bleeding was higher in antecedent aspirin users. When it was adjusted for the CRUSADE score, a similar risk was reported. Conclusion: Patients with de novo acute myocardial infarction using aspirin for primary prevention have an unexpectedly smaller infarct size and similar bleeding rates.Publication Metadata only Predictive Role of Monocyte to High-density Lipoprotein Ratio for Plaque Morphology in Asymptomatic Intermediate Carotid Stenosis(2020-01-01T00:00:00Z) KARAÇÖP, ERDEM; ENHOŞ, ASİM; KARAÇÖP, ERDEM; ENHOŞ, ASIMPublication Metadata only Prognostic impact of chronic obstructive pulmonary disease in octogenarians undergoing transcatheter aortic valve replacement(2020-12-06T00:00:00Z) KARAÇÖP, ERDEM; ENHOŞ, ASİM; BAKSHALİYEV, NİJAD; ÖZDEMİR, RAMAZAN; KARAÇÖP, ERDEM; ENHOŞ, ASIM; ÖZDEMİR, RAMAZANPublication Metadata only The analysis of the relationship between low vitamin D levels and cardiovascular diseases: hypertension, cardiac hypertrophy, atrial fibrillation, stroke(2020-12-06T00:00:00Z) UÇAR, OĞUZHAN; BACAKSIZ, AHMET; KULA, ASLI YAMAN; ÖZDEMİR, RAMAZAN; HOCAOĞLU, NİSA; ENHOŞ, ASİM; KARAÇÖP, ERDEM; BACAKSIZ, AHMET; ÖZDEMİR, RAMAZAN; ENHOŞ, ASIM; KARAÇÖP, ERDEMPublication Open Access P Wave Duration/P Wave Voltage Ratio Plays a Promising Role in the Prediction of Atrial Fibrillation: A New Player in the Game(2021-05-01T00:00:00Z) KARAÇÖP, ERDEM; ENHOŞ, Asim; BAKHSALIYEV, NIJAD; ÖZDEMİR, Ramazan; KARAÇÖP, ERDEM; ENHOŞ, ASIM; BAKHSALIYEV, NIJAD; ÖZDEMİR, RAMAZANBackground. Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. Identification of patients at risk for developing AF and the opportunity for early targeted intervention might have a significant impact on morbidity and mortality. Prolonged P wave duration and decreased P wave voltage have been shown to be independent predictors of AF. The present study aimed to investigate the role of P wave duration/P wave voltage in predicting new-onset AF. Methods. We screened a total of 640 consecutive patients who admitted to cardiology outpatient clinic with a complaint of palpitation between 2012 and 2014. 24-h Holter monitoring, echocardiography, and electrocardiography (ECG) recordings were reviewed to identify new-onset AF. Patients were assigned into two groups based on presence (n = 150) and absence (n = 490) of new-onset AF. Previous ECGs with sinus rhythm were analyzed. P wave duration was measured in inferior leads, and P wave voltage was measured in lead one. P wave duration/P wave voltage was also calculated for each patient. Results. One hundred fifty subjects (23.4%) had new-onset AF among 640 patients. P wave duration (123.27 +/- 12.87 vs. 119.33 +/- 17.39 ms, p=0.024) and P wave duration/P wave voltage (1284.70 +/- 508.03 vs. 924.14 +/- 462.06 ms/mV, p<0.001) were higher, and P wave voltage (0.12 +/- 0.04 vs. 0.13 +/- 0.04 mV, p<0.001) was significantly lower in the new-onset AF group compared with non-AFs. P wave duration/P wave voltage, with a cut off of 854.5 ms/mV, had 83.3% sensitivity and 62.0% specificity in a receiver operating characteristic curve (AUC 0.728, 95% CI 0.687-0.769; p<0.001). Their negative and positive predictive values were 78.7% and 68.6%, respectively. In a univariate regression analysis, age, smoking, C-reactive protein, brain natriuretic peptide, left atrial diameter, left atrial volume index, P wave duration, P wave voltage, and P wave duration/P wave voltage were significantly associated with the development of new-onset AF. Moreover, smoking (OR 4.008, 95% CI 1.707-9.409; p=0.001), left atrial volume index (OR 7.108, 95% CI 4.400-11.483; p<0.001), and P wave duration/P wave voltage (OR 1.002, 95% CI 1.000-1.003; p=0.044) were found to be significant independent predictors of new-onset AF in a multivariate analysis, after adjusting for other risk parameters. Conclusion. The P wave duration/P wave voltage ratio is a practical, easy-to-use, cheap, and reliable electrocardiographic parameter, which can play a promising role for both in predicting and elucidating a mechanism of new-onset AF.Publication Open Access Predictive role of ventricular repolarization parameters for the occurrence of complete heart block in patients undergoing transcatheter aortic valve implantation(2020-07-01T00:00:00Z) KARAÇÖP, ERDEM; ENHOŞ, Asim; KARAÇÖP, ERDEM; ENHOŞ, ASIMBackground We investigated the role of ventricular repolarization parameters to predict complete atrioventricular block in patients undergoing transcatheter aortic valve implantation (TAVI). Methods A total of 150 patients undergoing TAVI due to severe aortic stenosis were included in this retrospective cohort study. Patients were assigned in two groups based on the presence (n: 49) or absence (n: 101) of complete atrioventricular block after TAVI. Ventricular repolarization intervals (QT, QTc, JT, JTc, TP-E), indices (QT dispersion), and ratios (TP-E/QT, TP-E/QTc, TP-E/JTc) were measured. Results Electrocardiographic repolarization parameters such as Tp-e interval: 74.2 +/- 5.1 versus 59.2 +/- 6.1 ms,p < .001; QTc interval: 397.6 +/- 3.4 versus 368.1 +/- 7.8 ms,p < .001; JTc interval: 317.4 +/- 11.3 versus 291.1 +/- 6.7 ms,p < .001; Tp-e/QT ratio: 0.28 +/- 0.04 versus 0.20 +/- 0.04,p < .001; Tp-e/QTc ratio: 0.29 +/- 0.04 versus 0.19 +/- 0.03,p < .001; Tp-e/JT ratio: 0.32 +/- 0.03 versus 0.23 +/- 0.03,p < .001; Tp-e/JTc ratio: 0.30 +/- 0.02 versus 0.2 +/- 0.03,p < .001; and QT dispersion: 34.4 +/- 3.0 versus 17.8 +/- 3.6 ms,p < .01 were significantly higher in post-TAVI permanent pacemaker group. In a univariate regression analysis, pulmonary artery pressure, heart rate, coronary artery disease, Tp-e/QTc, Tp-e/JTc, and PR interval were significantly associated with complete heart block. Tp-e/JTc (OR 0.373,p = .067) and PR interval (OR 0.898,p = .079) were found to be independent predictors of these type of arrhythmias in a multivariate analysis. But it is not statistically significant. Conclusion Our results suggest that repolarization parameters may play a role in predicting complete atrioventricular block. Tp-e/JTc was found to be potential independent risk marker for this setting.Publication Metadata only Impact of atrial flow regulator (AFR) implantation on 12-month mortality in heart failure Insights from a single site in the PRELIEVE study(2021-08-01T00:00:00Z) BAKHSALIYEV, NIJAD; ÇELİKKALE, İLKE; ENHOŞ, Asim; KARAÇÖP, ERDEM; ULUGANYAN, Mahmut; ÖZDEMİR, Ramazan; BAKHSALIYEV, NIJAD; ÇELİKKALE, İLKE; ENHOŞ, ASIM; KARAÇÖP, ERDEM; ULUGANYAN, MAHMUT; ÖZDEMİR, RAMAZANBackground Implantation of the atrial flow regulator (AFR) to create an interatrial left-to-right shunt has been shown to be safe and feasible to reduce intracardiac filling pressures in patients with heart failure (HF). Objectives We aimed to assess the effect of AFR implantation on 12-month mortality and hospitalization rates in patients with reduced (HFrEF) or preserved HF (HFpEF). Methods One-year follow-up data from 34 subjects enrolled at a single PRELIEVE center were analyzed. The 12-month predicted mortality was calculated using the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk score. Patients were divided into two groups, according to their history of hospitalizations for HF. Results Study data of 34 patients (HFrEF: 24 [70.6%]; HFpEF: 10 [29.4%]) were assessed. Median follow-up duration was 355 days. In total, 14 (41.2%) patients were hospitalized during the follow-up period and 6 (17.6%) of these patients were hospitalization for HF (HHF). A total of 24 hospitalizations occurred in this period and 8 (33%) hospitalizations were for HHF. The median baseline MAGGIC score was 23 and the median predicted mortality was 13.4/100 patient years. Observed mortality was 3.1/100 patient years. The observed survival (97%) was 10.3% (95% confidence interval 3.6-17.5%, p = 0.004) better than the predicted survival (86.6%). Conclusion Our results suggest that AFR implantation has favorable effects on mortality in patients with heart failure, regardless of ejection fraction. Furthermore, compared to baseline, left ventricular filling pressure (assessed by echocardiography) decreased significantly without right side volume overload at the 1-year follow-up.Publication Metadata only P wave duration / P wave voltage ratio plays a strong role for prediction of atrial fibrillation: A new player in the game(2020-12-06T00:00:00Z) KARAÇÖP, ERDEM; ENHOŞ, ASİM; BAKSHALİYEV, NİJAD; ÖZDEMİR, RAMAZAN; KARAÇÖP, ERDEM; ENHOŞ, ASIM; ÖZDEMİR, RAMAZANPublication Metadata only Is elevated monocyte to high-density lipoprotein ratio a predictor of symptomatic plaque in patients with intermediate carotid artery stenosis?(2020-01-01T00:00:00Z) ENHOŞ, ASİM; KARAÇÖP, ERDEM; ENHOŞ, ASIM; KARAÇÖP, ERDEM