Person: ÜSTÜNOVA, SAVAŞ
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Publication Metadata only The Effect of Theobroma Cacao on Hyperlipidemic Rats(2019-03-14) Kılıç A.; Üstünova S.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞPublication Metadata only The Protective Effect of Cinnamomum Zeylanicum in Streptozotocin-Induced Diabetic Rats(2019-03-29) Kılıç A.; Üstünova S.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞPublication Open Access Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart(2020-09-01T00:00:00Z) ÜSTÜNOVA, SAVAŞ; TAKIR, SELÇUK; YILMAZER, NADİM; Bulut, Huri; ALTINDİREK, Didem; HATIRNAZ NG, Özden; Tansel, Cihan Demirci; Dogan, B. Sonmez Uydes; ÖZBEK, Uğur; ARMUTAK, Elif İlkay; Gurevin, Ebru Gurel; ÜSTÜNOVA, SAVAŞBackground/Aim: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in ischemia/reperfiision (I/R) injury. Materials and Methods: Rat hearts were studied with the Langendorff technique using the H2S donor sodium hydrosulfide (NaHS, 40 mu M) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation. The hearts were homogenized for biochemical and molecular analysis. Results: NaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME. Conclusion: H2S and NO increase each other-s production suggesting their interaction and cooperation in cardioprotection against I/R injury.Publication Metadata only The Effect of S-Allylcysteine on Gastric Injury Induced by Cold Restraint Stress(2019-03-29) Üstünova S.; Kılıç A.; Bulut H.; Üyüklü M.; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSUPublication Metadata only Sulodexide protected the heart against ischemia/reperfusion injury by reducing oxidative stress, inflammation, and apoptosis in the isolated rat heart(2022-11-17) ÜSTÜNOVA S.; AKSOY R.; BULUT H.; KILIÇ A.; MERAL İ.; RABUŞ M. B.; BOZKURT A. K.; KÖKSAL C.; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; MERAL, İSMAİL; KÖKSAL, CENGİZPublication Metadata only Effects of Thymoquinone On Erythrocyte Aggregation Kinetics: An In Vitro Study(2022-01-01T00:00:00Z) ÜSTÜNOVA, SAVAŞ; Uyuklu, Mehmet; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİL© 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Erythrocyte aggregation is associated with a series of physio-pathological processes in body and according to this, current study was designed to examine how the thymoquinone (TQ) and a ggregation kinetics relation changes when the aggregation properties of erythrocyte suspensions are intervened using different approaches, such as changing the suspension environment or erythrocyte surface properties. Blood samples from 40 male Wistar albino rats (three months old weighing 250-300 g) were randomly divided into four groups, as 1) whole blood (control), 2) 1/2 dilution (plasma was diluted with PBS), 3) dextran 500 (1% dextran 500 was dissolved in plasma) and 4) glutaraldehyde. Blood samples were taken from abdominal aorta under anesthesia. The erythrocyte suspensions were incubated at 37°C for one hour in the absence or presence of TQ, with a final concentration of 1 mg/ml. Then, the electrical properties of erythrocyte suspensions were recorded, and the electrical capacitance was monitored using an inductance, capacitance, and resistance meter (LCR meter) at 100 kHz. It was found that TQ incubation decreased the aggregation index in control and dextran groups while increased it in 1/2 dilution and GA groups. It was also found that TQ incubation increased the time constant in whole blood and dextran while decreased it in 1/2 dilution and GA. The TQ can normalize the altered erythrocyte aggregation responses in both ways that is, it decreases the increased aggregation or increases the decreased aggregation. Therefore, it may have very critical role in rouleaux formation-induced circulatory disorders.Publication Metadata only Protective Effect of Potassium Channel Blockade and Nitric Oxide in Erythrocytes Exposed to Mechanical Trauma in Diabetic Rats(2019-03-14) Kılıç A.; Üstünova S.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞPublication Metadata only Protective Effect of Potassium Channel Blockade and Nitric Oxide in Erythrocytes Exposed to Mechanical Trauma in Hyperlipidemic Rats(2019-03-14) Kılıç A.; Üstünova S.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞPublication Metadata only Serum Electrolyte Values and Blood Oxidative Stress Parameters in Patients with Focal and Generalized Epilepsy(2023-02-01) Sarı G.; Kılıç A.; Uslu F.; Selek Ş.; Üstünova S.; Meral İ.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİLPublication Metadata only Stres Maruziyeti Sonrası Uygulanan Timokinon Tedavisinin Sıçanlarda Öğrenme ve Bellek Üzerindeki Etkisinin NMDA Reseptörleri ile İlişkisinin Değerlendirilmesi(2023-12-21) Altuntaş E.; İpek B. E.; Kılıç A.; Üstünova S.; İPEK, BETÜL ESRA; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ