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ÜSTÜNOVA, SAVAŞ

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SAVAŞ
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ÜSTÜNOVA
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End date: 2019 × Start date: 2011 × Item Type: Publication ×

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Now showing 1 - 10 of 29
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    The Effect of Theobroma Cacao on Hyperlipidemic Rats
    (2019-03-14) Kılıç A.; Üstünova S.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ
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    FİZYOLOJİ
    (2019-02-01) MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞ
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    Effects of Angiotensin IV on Learning-Memory and Hippocampal Oxidative Stress in Diabetic Rats
    (2019-12-01T00:00:00Z) KILIÇ, Aysu; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; Bulut, Huri; MERAL, İSMAİL; Sahin, Emine Gulderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; BULUT, HURI; MERAL, İSMAİL
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    The Protective Effect of Cinnamomum Zeylanicum in Streptozotocin-Induced Diabetic Rats
    (2019-03-29) Kılıç A.; Üstünova S.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ
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    Role of Angiotensin TYpe I and II receptor Blockade in Ischemia/Reperfusion Injury of Isolated Rat Heart
    (2017-05-04) Kılıç, AYSU; ÜSTÜNOVA, SAVAŞ; Usta, Cansu; BULUT, HURİ; ÜYÜKLÜ, MEHMET; Demirci-Tansel, Cihan; MERAL, İSMAİL; Artumak, Elif; Gurevin-Gürel, Ebru; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; BULUT, HURI; ÜYÜKLÜ, MEHMET; MERAL, İSMAİL
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    Role of ischemic preconditioning and tempol in ischemia/reperfusion injury in isolated rat heart
    (2013-07-01T00:00:00Z) Erol, D.; Ustunova, SAVAŞ; Gurel, E.; Dedeakayogullari, H.; Demirci-Tansel, C.; ÜSTÜNOVA, SAVAŞ
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    Hexokinase cellular trafficking in ischemia-reperfusion and ischemic preconditioning is altered in type I diabetic heart
    (2013-07-01T00:00:00Z) Gurel, Ebru; Ustunova, SAVAŞ; Kapucu, Aysegul; Yilmazer, Nadim; EERBEEK, Otto; NEDERLOF, Rianne; HOLLMANN, Markus W.; Demirci-Tansel, Cihan; ZUURBIER, Coert J.; ÜSTÜNOVA, SAVAŞ
    Diabetes mellitus (DM) has been reported to alter the cardiac response to ischemia-reperfusion (IR). In addition, cardioprotection induced by ischemic preconditioning (IPC) is often impaired in diabetes. We have previously shown that the subcellular localisation of the glycolytic enzyme hexokinase (HK) is causally related to IR injury and IPC protective potential. Especially the binding of HK to mitochondria and prevention of HK solubilisation (HK detachment from mitochondria) during ischemia confers cardioprotection. It is unknown whether diabetes affects HK localisation during IR and IPC as compared to non-diabetes. In this study we hypothesize that DM alters cellular trafficking of hexokinase in response to IR and IPC, possibly explaining the altered response to IR and IPC in diabetic heart. Control (CON) and type I diabetic (DM) rat hearts (65 mg/kg streptozotocin, 4 weeks) were isolated and perfused in Langendorff-mode and subjected to 35 min I and 30 min R with or without IPC (3 times 5 min I). Cytosolic and mitochondrial fractions were obtained at (1) baseline, i.e. after IPC but before I, (2) 35 min I, (3) 5 min R and (4) 30 min R. DM improved rate-pressure product recovery (RPP; 71 +/- A 10 % baseline (DM) versus 9 +/- A 1 % baseline (CON) and decreased contracture (end-diastolic pressure: 24 +/- A 8 mmHg (DM) vs 77 +/- A 4 mmHg (CON)) after IR as compared to control, and was associated with prevention of HK solubilisation at 35 min I. IPC improved cardiac function in CON but not in DM hearts. IPC in CON prevented HK solubilisation at 35 min I and at 5 min R, with a trend for increased mitochondrial HK. In contrast, the non-effective IPC in DM was associated with solubilisation of HK and decreased mitochondrial HK at early reperfusion and a reciprocal behaviour at late reperfusion. We conclude that type I DM significantly altered cellular HK translocation patterns in the heart in response to IR and IPC, possibly explaining altered response to IR and IPC in diabetes.
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    The Effect of S-Allylcysteine on Gastric Injury Induced by Cold Restraint Stress
    (2019-03-29) Üstünova S.; Kılıç A.; Bulut H.; Üyüklü M.; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU
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    Effects of Nigella sativa on apoptosis and GABA(A) receptor density in cerebral cortical and hippocampal neurons in pentylenetetrazol induced kindling in rats
    (2016-01-01) AYDIN, M. S.; USTUNOVA, SAVAŞ; ESREFOGLU, MUKADDES; MERAL, I.; Arifoglu, YASİN; DEMIRTAS, M.; MERAL, İSMAİL; EŞREFOĞLU, MUKADDES; ÜSTÜNOVA, SAVAŞ; ARİFOĞLU, YASİN
    We investigated the effects of Nigella sativa on apoptosis and gamma-aminobutyric acid (GABA(A)) receptor density in cerebral cortical and hippocampal neurons in a pentylenetetrazol (PTZ)-induced kindling model in rats. The PTZ kindling model was produced by injecting PTZ in subconvulsive doses to rats on days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22 and 24 of the study into animals of PTZ treated (PTZ) and PTZ + N. sativa treated (PTZ + NS) groups. Clonic and tonic seizures were induced by injecting a convulsive dose of PTZ on day 26 of the study. Rats in the PTZ + NS group were treated also with a 10 mg/kg methanolic extract of N. sativa 2 h before each PTZ injection. Rats in the control group were treated with 4 ml/kg saline. The number of neurons that expressed GABA(A) receptors in the hippocampus and cerebral cortex of rats in the PTZ and PTZ + NS groups increased significantly. There was no significant difference in the number of GABA(A) receptors between the PTZ and PTZ + NS groups. GABA(A) receptor density of the neurons in the cerebral cortex, but not hippocampus, was increased in PTZ group compared to controls. We observed a significant increase in the number of apoptotic neurons in the cerebral cortex of rats of both the PTZ and PTZ + NS groups compared to controls. We observed a significant decrease in the number of the apoptotic neurons in the cerebral cortex of rats in the PTZ + NS group compared to the PTZ group. N. sativa treatment ameliorated the PTZ induced neurodegeneration in the cerebral cortex as reflected by neuronal apoptosis and neuronal GABA(A) receptor frequency.
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    Herbal Haemorrhoidal Cream for Haemorrhoids
    (2013-10-31T00:00:00Z) Gurel, Ebru; Ustunova, SAVAŞ; Ergin, Bulent; Tan, Nur; Caner, Metin; Tortum, Osman; Demirci-Tansel, Cihan; ÜSTÜNOVA, SAVAŞ
    Although hemorrhoids are one of the most common diseases in the world, the exact etiology underlying the development of hemorrhoids is not clear. Many different ointments are currently used to treat hemorrhoids; however, there is little evidence of the efficacy of these treatments to support their use. The aim of this study was to compare different herbal creams used for the treatment of hemorrhoids. Twenty-eight male Wistar albino rats, 6-8 weeks old and weighing 160-180 g, were used in this study as 1-control, 2-croton oil, 3-croton oil+fig leaves+artichoke leaves+walnut husks and 4-croton oil+fig leaves+artichoke leaves+walnut husks+horse chestnut fruit. After 3 days of croton oil application, rats were treated with 0.1 ml of cream or saline twice a day for 15 days by syringe. Tissue and blood samples were collected for histological, immunohistochemical and biochemical studies. Statistical significance was determined using one-way ANOVA followed by Tukey-s multiple comparison tests. Croton oil administration resulted in severe inflammation. The third group showed partial improvement in inflammation; however, the greatest degree of improvement was seen in the fourth group, and some recovered areas were observed. Myeloperoxidase immunoreactivity was found to be decreased in the third and fourth groups compared to the second group. Additionally, biochemical analyses (Myeloperoxidase, Malondyaldehyde, nitrate/nitrite and nitrotyrosine levels and Superoxide Dismutase activity) were in agreement with the histological and immunohistochemical results. In conclusion, croton oil causes inflammation in the anal area and results in hemorrhoids. Treatment with our herbal hemorrhoid creams demonstrated anti-inflammatory and anti-oxidant effects in this model.