Person: ÜSTÜNOVA, SAVAŞ
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Publication Metadata only The Effect of Theobroma Cacao on Hyperlipidemic Rats(2019-03-14) Kılıç A.; Üstünova S.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞPublication Metadata only Effects of Angiotensin IV on Learning-Memory and Hippocampal Oxidative Stress in Diabetic Rats(2019-12-01T00:00:00Z) KILIÇ, Aysu; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; Bulut, Huri; MERAL, İSMAİL; Sahin, Emine Gulderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; BULUT, HURI; MERAL, İSMAİLPublication Metadata only The Protective Effect of Cinnamomum Zeylanicum in Streptozotocin-Induced Diabetic Rats(2019-03-29) Kılıç A.; Üstünova S.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞPublication Metadata only Role of Angiotensin TYpe I and II receptor Blockade in Ischemia/Reperfusion Injury of Isolated Rat Heart(2017-05-04) Kılıç, AYSU; ÜSTÜNOVA, SAVAŞ; Usta, Cansu; BULUT, HURİ; ÜYÜKLÜ, MEHMET; Demirci-Tansel, Cihan; MERAL, İSMAİL; Artumak, Elif; Gurevin-Gürel, Ebru; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; BULUT, HURI; ÜYÜKLÜ, MEHMET; MERAL, İSMAİLPublication Metadata only The Effect of S-Allylcysteine on Gastric Injury Induced by Cold Restraint Stress(2019-03-29) Üstünova S.; Kılıç A.; Bulut H.; Üyüklü M.; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSUPublication Metadata only Sulodexide protected the heart against ischemia/reperfusion injury by reducing oxidative stress, inflammation, and apoptosis in the isolated rat heart(2022-11-17) ÜSTÜNOVA S.; AKSOY R.; BULUT H.; KILIÇ A.; MERAL İ.; RABUŞ M. B.; BOZKURT A. K.; KÖKSAL C.; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; MERAL, İSMAİL; KÖKSAL, CENGİZPublication Open Access Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels(2021-01-01T00:00:00Z) KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; Bulut, Huri; MERAL, İSMAİL; Sahin, Gulderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; MERAL, İSMAİLIn this study, we investigated the protective effects of angiotensin IV (Mg IV) on cognitive function in streptozotocin (STZ)-induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control (C), diabetes (Dia, 60 mg/kg, STZ, i.p.), Mg IV (5 mu g/kg, s.c.) and Dia+Ang W. The passive avoidance and Morris water maze (MWM) tests were used to evaluate learning and memory performance. Behavioral tests were carried out between 21 and 30 days after the initial Ang IV injection. Hippocampi were dissected and retained for biochemical and Western blot analysis. The Dia group exhibited the poorest behavioral results, while the Dia+Ang W group performed highest on the MWM task. Superoxide dismutase, glutathione peroxidase, and malondialdehyde levels increased significantly in the Dia group compared to Dia+Ang IV. Brain-derived neurotrophic factor (BDNF) and N-methyl-D-aspartate levels were significantly elevated, while levels of GABA(A) significantly decreased, in the Dia+Ang IV group compared to the Dia group. These findings suggest that peripheral administration of Ang IV ameliorated spatial memory in diabetic rats by decreasing hippocampal oxidative stress and BDNF levels.Publication Metadata only The Effects of Therapeutic Intermittent Hypoxia Implementation on Complete Blood Count Parameters: An Experimental Animal Model(2022-12-01T00:00:00Z) KILIÇ, TALHA; ŞENGÖR, MUSTAFA; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; DAŞKAYA, HAYRETTİN; YILDIZ ÖZER, AYSEL; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; DAŞKAYA, HAYRETTİNPublication Metadata only Effect of Thymoquinone on Ischemia/Reperfusion Injury in Isolated Hearts of Streptozotocin-Induced Diabetic Rats(2019-12-01T00:00:00Z) ÜSTÜNOVA, SAVAŞ; KILIÇ, Aysu; Bulut, Hun; MERAL, İSMAİL; Alican, Inci; ÜSTÜNOVA, SAVAŞ; KILIÇ, AYSU; MERAL, İSMAİLPublication Metadata only The Effects of an Herbal Hemorrhoid Cream on Liver in Carbontetrachloride Treated Animals(2017-07-15) KANDİL, ASlI; Kılıç, AYSU; GUREVIN, EBRU GUREL; SOGUT, IBRAHIM; ÜSTÜNOVA, SAVAŞ; Eren, Şeyma; DEMIRCI-TANSEL, C.; CANER, M.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ