Person: ÜSTÜNOVA, SAVAŞ
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Publication Metadata only GÜNCEL FARMAKOLOJİ Fizyoloji Temelinde Hasta Odaklı Yaklaşım(2022-09-01T00:00:00Z) Üstünova, Savaş; ÜSTÜNOVA, SAVAŞPublication Open Access Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentyleneterazole-PTZ Kindling in Rats.(2021-08-01T00:00:00Z) Meral, İsmail; Eşrefoğlu, Mukaddes; Kara, Mehmet; Erkeç, Özlem Ergül; Tok, Olgu Enis; Armağan, Metin; MERAL, İSMAİL; EŞREFOĞLU, MUKADDES; ÜSTÜNOVA, SAVAŞPublication Metadata only EFFECTS OF ASPARTAM CONSUMPTION ON BEHAVIORAL PARAMETERS IN RATS(2022-07-05T00:00:00Z) Üstünova, Savaş; Alkhalidi, Damla; ÜSTÜNOVA, SAVAŞPublication Metadata only Medikal Fizyoloji (Walter F. Boron, Emile L. Boulpaep)(2020-09-01T00:00:00Z) Üstünova, Savaş; ÜSTÜNOVA, SAVAŞPublication Metadata only Angiotensin IV’ün Diyabetik Sıçanlarda Öğrenme-Bellek ve Hipokampal Oksidatif Stres Üzerine Etkisi(2019-11-03) Kılıç, Aysu; Üstünova, Savaş; Elibol, Birsen; Bulut, Huri; Meral, İsmail; Şahin, Emine Gülderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; MERAL, İSMAİLPublication Metadata only KOLŞİSİN TEDAVİSİNİN NÖROİNFLAMASYONLU HÜCRELERDE NRLP3 İNFLAMAZOM AKTİVASYONU İLE İLİŞKİSİ(2022-05-20T00:00:00Z) Hacıosmanoğlu, Ebru; Üstünova, Savaş; ÜSTÜNOVA, SAVAŞPublication Metadata only Leptin Enhances Nitric Oxide Production and Decreases Blood Flow in Rat Skeletal Muscle(2022-04-01T00:00:00Z) Üstünova, Savaş; Kapucu, Ayşegül; Demirci Tansel, Cihan; ÜSTÜNOVA, SAVAŞPublication Open Access A low direct electrical signal attenuates oxidative stress and inflammation in septic rats(2021-09-01T00:00:00Z) Üstünova, Savaş; Hacıosmanoğlu, Ebru; Bulut, Huri; Kılıç, Aysu; Hekimoğlu, Emine Rümeysa; Tunc, Serkan; Kaygusuz, İrem; Tunc, Sevil; Tunc, Gulcin Beyza; Meral, Ismail; ÜSTÜNOVA, SAVAŞ; HACIOSMANOĞLU, EBRU; ELİBOL, BİRSEN; KILIÇ, AYSU; HEKİMOĞLU, EMİNE RÜMEYSA; MERAL, İSMAİLElectrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE) groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating changes in the histological structure of tissues, blood pH, gases, viscosity and cell count, activities of some important enzymes, oxidative stress parameters, inflammation and tissue apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.Publication Metadata only Effects of Nigella sativa on Plasma Oxidative Stress, and Some Apoptotic Protein Markers in Cerebrum and Hippocampus in Pentylenetetrazol-Induced Kindling Rats(2020-12-01T00:00:00Z) Üstünova, Savaş; Meral, İsmail; Koçyiğit, Abdürrahim; Kılıç, Aysu; Zeybek, Öykü; Meydan, Sedat; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİL; KOÇYİĞİT, ABDÜRRAHİM; KILIÇ, AYSU; MEYDAN, SEDATPublication Metadata only Sıçanlarda Soğuk Hareketsizlik Stresine Bağlı Gelişen Mide Hasarında S-Allyl Cysteine-in Koruyucu Etkisi(2020-03-07T00:00:00Z) Üyüklü, Mehmet; Taş, Fatih; Bolatlı, Güneş; Özçelik, Faruk; Üstünova, Savaş; Bulut, Huri; ÜSTÜNOVA, SAVAŞ