Person: TUĞRUL, SELAHATTİN
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Publication Metadata only Effect of Submucosal Mesna Application on Mucoperichondrial Elevation in Septoplasty(2017-01-01) Dogan, REMZİ; Yenigun, ALPER; Eren, SABRİ BAKİ; Ozturan, ORHAN; Goktas, Seda Sezen; Tugrul, Selahattin; Calim, Omer Faruk; EREN, SABRİ BAKİ; YENİGÜN, ALPER; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; ÇALIM, ÖMER FARUK; ÖZTURAN, ORHANObjective: It was revealed that the thiol compound named mesna chemically softens the connective tissue with submucosal injection, and facilitates the endoscopic submucosal dissection. The authors aimed to investigate the effect of mesna injection on mucoperichondrial elevation during septoplasty operation. Methods: This study was planned as a patient-control study and performed. Fifty-six patients who had septoplasty operation were divided into 2 groups that are submucosal mesna (group 1) and submucosal saline (group 2) applied ones. In both groups, the measurement was initiated by a timer during the start of septal incision and elevation processes. After bilateral subperichondrial and subperiostal elevation were finished, timer was stopped and time was recorded. After that, mucosal integrity was reviewed and mucosal damage status was recorded. The difficulty of mucoperichondrial elevation for the surgeon was recorded for each patient. Results: Twenty-five (44.7%) of the patients who participated in our study were females while 31 (55.3%) were males. The average elevation periods were 201.4 +/- 74.3 seconds in group 1 and 260.2 +/- 84.1 seconds in group 2. In mesna applied patients, elevation period was statistically and significantly shorter (P = 0.009). Impairment in mucosal integrity was observed as 33.3% in group 1 and 58.8% in group 2. In mesna applied patients, significantly less impairment in mucosal integrity was observed (P = 0.031). The average mucoperichondrial elevation difficulty for the surgeon is observed as 4.83 +/- 2.47 in group 1 and 6.5 +/- 1.9 in group 2. Mesna applied patients were defined as significantly easier patients for the surgeon (P = 0.006). Conclusion: Submucosal mesna application is an approach that provides a convenient, fast, and effective mucoperichondrial elevation in septoplasty and protects the mucosal integrity.Publication Metadata only Pediatrik Akut Rinosinüzit Tedavisinde Düşük Basınçlı Yüksek Volümlü nazal Salin Flutikazon Propionat Uygulaması(2014-05-25T00:00:00Z) TUĞRUL, SELHATTİN; DOĞAN, REMZİ; EREN, SABRİ BAKİ; MERİÇ HAFIZ, AYŞENUR; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; EREN, SABRİ BAKİ; MERİÇ HAFIZ, AYŞENUR; ÖZTURAN, ORHANPublication Metadata only Does systemic steroid deficiency affect inner ear functions?(2015-07-01) Dogan, REMZİ; MERIC, Aysenur; Gedik, Ozge; TUGRUL, Selahattin; Eren, SABRİ BAKİ; Ozturan, ORHAN; DOĞAN, REMZI; MERİÇ HAFIZ, AYŞENUR; GEDİK, ÖZGE; TUĞRUL, SELAHATTİN; EREN, SABRİ BAKİ; ÖZTURAN, ORHANPurpose: Today corticosteroids are employed for the treatment of various inner ear disorders. In this study we have investigated probable changes in hearing functions resulting from a deficiency of systemic steroid secretions.Publication Metadata only Analgesic effect of magnesium in post-tonsillectomy patients: a prospective randomised clinical trial(2015-09-01) TUGRUL, SELHATTİN; EREN, S. B.; Dogan, REMZİ; VEYSELLER, B.; OZTURAN, ORHAN; TUĞRUL, SELAHATTİN; DEĞİRMENCİ, NAZAN; EREN, SABRİ BAKİ; DOĞAN, REMZI; ÖZTURAN, ORHANThe aim of this study was to assess the analgesic, bleeding and nausea/vomiting effects of magnesium with and without metamizol on post-tonsillectomy patients. This prospective and randomised clinical trial included 54 patients aged 18-63 years who were scheduled for elective tonsillectomy. The patients were randomly divided into two groups and administered either magnesium with metamizol or only metamizol. They had been classified as physical status class I and II using the American Society of Anesthesiologists guidelines. All patients underwent the same surgical procedure performed by a single surgeon. The groups did not differ according to age, sex, or duration of anaesthesia or surgery. Postoperative pain, bleeding and nausea/vomiting were evaluated using the VAS and bleeding and nausea/vomiting scores on the first, fifth and tenth days. On the first, fifth and tenth postoperative days, the VAS scores of the magnesium with metamizol group were significantly lower than those of the metamizol-only group (p1 = 0.001; p5 = 0.015; p10 = 0.015). There were no significant differences in postoperative bleeding and nausea/vomiting scores between the two groups (p = 0.425 and p = 0.258, respectively). This study showed that magnesium enhanced the analgesic effect on post-tonsillectomy pain. Use of magnesium with an analgesic drug may be beneficial for management of post-tonsillectomy pain .Publication Metadata only Evaluation of nasal mucociliary transport rate according to nasal septum deviation type(2016-07-01) Dogan, REMZİ; TUGRUL, Selahattin; Erdogan, EZGİ BAŞAK; Eren, SABRİ BAKİ; Ozturan, ORHAN; DOĞAN, REMZI; TUĞRUL, SELAHATTİN; ERDOĞAN, EZGİ BAŞAK; EREN, SABRİ BAKİ; ÖZTURAN, ORHANBackgroundNasal septum deviation (NSD) may affect mucociliary activity (MCA) to varying degrees, depending upon the severity of the deviation. We used rhinoscintigraphy to determine the impact of the various NSD types on MCA.Publication Metadata only Efficacy of nasal corticosteroid in preventing regrowth after adenoidectomy(2016-12-01) TUGRUL, Selahattin; Yildirim, YAVUZ SELİM; SENTURK, EROL; Eren, SABRİ BAKİ; Dogan, REMZİ; Ozturan, ORHAN; YILDIRIM, YAVUZ SELİM; ŞENTÜRK, EROL; EREN, SABRİ BAKİ; DOĞAN, REMZI; TUĞRUL, SELAHATTİN; ÖZTURAN, ORHANObjective: One of the most frequent reasons of nasal obstruction and sleep apnea in pediatrics is adenoid hypertrophy. Remaining adenoid tissue can reoccur following hypertrophied adenoid removal and a second operation may be needed. Nasal corticosteroids are utilized in order to reduce adenoid hypertrophy and eliminate adenoidectomy operation. The purpose of our study is to assess the effect of nasal corticosteroid administration after adenoidectomy on adenoid regrowth and symptom scores.Publication Metadata only RGB measurements as a novel objective test for otitis media with effusion(2015-03-05T00:00:00Z) TUĞRUL, SELHATTİN; DEĞİRMENCİ, NAZAN; EREN, SABRİ BAKİ; DOĞAN, REMZİ; MERİÇ HAFIZ, AYŞENUR; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; DEĞİRMENCİ, NAZAN; EREN, SABRİ BAKİ; DOĞAN, REMZI; ÖZTURAN, ORHANPublication Metadata only Evaluation of ototoxicity of intratympanic administration of Methotrexate in rats(2017-09-01) EREN, SABRİ BAKİ; ÖZTURAN, ORHAN; TUGRUL, Selahattin; YENİGÜN, ALPER; DOĞAN, REMZİ; Aydin, Mehmet Serif; EREN, SABRİ BAKİ; DOĞAN, REMZI; YENİGÜN, ALPER; TUĞRUL, SELAHATTİN; ÖZTURAN, ORHANPublication Metadata only Use of Mesna in the treatment of ossicular chain fixation related to tympanosclerosis; prospective, clinical study.(2020-01-01T00:00:00Z) Tugrul, S; Dogan, R; Vural, Ö; Ozturan, O; Yenigun, Alper; Calım, ÖF; EREN, SABRİ BAKİ; TUĞRUL, SELAHATTİN; YENİGÜN, ALPER; ÇALIM, ÖMER FARUK; ÖZTURAN, ORHANObjective: Mesna is a thiol compound effective in the connective tissue, which is used for its chemical dissector, mucolytic, mucosal damage preventive and antioxidant effects. The aim of this study was to investigate Mesna-s effects in easy dissection in type 4 tympanosclerosis cases and in the prevention of formation of new sclerotic plaques.Publication Open Access Effect of Radiofrequency on DNA Damage and Oxidative Status in Patients with Turbinate Hypertrophy.(2019-11-01) Tugrul, S; Koçyiğit, A; Senturk, E; Doğan, Remzi; Eren, SB; Ozturan, ORHAN; Kesgin, S; ŞENTÜRK, EROL; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; EREN, SABRİ BAKİ; ÖZTURAN, ORHAN; KOÇYİĞİT, ABDÜRRAHİMThe radiofrequency devices that are used generate radiofrequency in the frequency range of 1.5 and 2.5 MHz. This study aims to demonstrate whether systematic oxidative status and DNA are influenced in this frequency range. In study, 27 patients who received radiofrequency treatment on inferior turbinate as they were diagnosed with inferior turbinate hypertrophy. DNA damage was assessed by alkaline comet assay in peripheral lymphocyte cells. Plasma levels of total antioxidant status (TAS), total oxidative status (TOS) were determined by using an automated measurement method and oxidative stress index (OSI) was calculated (OSI was calculated as: OSI = (TOS/TAS) × 100). There were increased in the OSI and TOS values on days 1 and 15 as compared to the samples taken before the radiofrequency administration. Significant decreases were seen in TAS values on days 1 and 15. As for the DNA damage, no significant differences were found on day 15 compared to the preoperative values even though there was a statistically insignificant increase on day 1. Administration of radiofrequency radiation on inferior turbinates results in increased oxidative stress in the acute period and a decrease in the anti-oxidative system. Although this effect causes a slight increase in the DNA damage in the early post-operative period, the damage is restored to the pre-operative levels on day 15. Therefore, we believe that a more conservative approach should be selected for radiofrequency treatment instead of using it routinely.