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VEHAPOĞLU TÜRKMEN, AYSEL

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2016 - 20174
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Author: OKTEM, Faruk × Author: Vehapoglu, Aysel ×

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    PublicationOpen Access
    Renal tubular function and urinary N-acetyl-beta-d-glucosaminidase and kidney injury molecule-1 levels in asthmatic children
    (2016-12-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; OKTEM, Faruk; Ozkaya, EMİN; Yazici, MEBRURE; Torun, EMEL; Vehapoglu, Aysel; KUCUKKOC, Mehmet; ÖZKAYA, EMİN; YAZICI, MEBRURE; TORUN, EMEL; VEHAPOĞLU TÜRKMEN, AYSEL
    Background: Asthma is a chronic inflammatory disorder of the airways which results in chronic hypoxia. Chronic hypoxia and inflammation can affect renal tubular function. Objectives: The aim of this study was to investigate renal tubular function and early kidney injury molecules such as urinary N-acetyl-betaglucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) excretion in children with asthma. Methods: Enrolled in the study were 73 children diagnosed with asthma and 65 healthy age- and gender-matched control subjects. Urine pH, sodium, phosphorus, potassium, microalbumin, creatinine, NAG, KIM-1, and serum creatinine, sodium, phosphorus were evaluated. The diagnosis of asthma and classification of mild or moderate were done according to the Global Initiative for Asthma guidelines. Results: Serum sodium, phosphorus, creatinine, and urinary microalbumin were within normal levels in the both groups. Urinary pH, sodium, potassium, phosphorus, microalbumin, and KIM-1 excretions were similar between the control and study groups. Tubular phosphorus reabsorption was within normal limits in two groups. Urine NAG was elevated in the study group (P = 0.001). Urinary KIM-1 and NAG levels were positively correlated (r = 0.837; P = 0.001). When children with mild and moderate asthma were compared, all of the parameters were similar (P >0.05). Conclusions: This study showed that chronic asthma can lead to subtle renal impacts. We suggest that in children with asthma, urinary NAG level is a more valuable parameter to show degree of renal tubular injury than markers such as microalbumin and KIM-1. Chronic hypoxy and inflammation probably contributes to these subclinical renal effects.
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    Evaluation of Autonomic Nervous System function in Children with Overactive Bladder Syndrome
    (2017-03-01) DEMIR, Aysegul Dogan; Gursoy, AZİZE ESRA; GOKNAR, Nilufer; Uzuner, SELÇUK; Ozkaya, EMİN; Erenberk, UFUK; Vehapoglu, Aysel; DUNDAROZ, Mehmet Rusen; OKTEM, Faruk; GÜRSOY, AZIZE ESRA; UZUNER, SELÇUK; ÖZKAYA, EMİN; ERENBERK, UFUK; VEHAPOĞLU TÜRKMEN, AYSEL
    Purpose We aimed to evaluate the autonomic nervous system activity in children with overactive bladder (OAB) syndrome.Methods Included in the study were 40 children with overactive bladder and 28 healthy controls. Autonomic tests were performed on all participants, including heart rate interval variation (RRIV), heart rate response to valsalva maneuver, and sympathetic skin response (SSR).Results Mean valsalva rates in the overactive bladder and control groups were 1.530.29 and 1.30 +/- 0.18, respectively, a statistically significant difference (P0.05).Conclusions This study demonstrated a parasympathetic hyperactivity in children with OAB, results suggesting a dysfunction in their autonomic nervous systems. (C) 2016 Wiley Periodicals, Inc.
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    Association between myeloperoxidase gene polymorphism and familial mediterranean fever in Turkish Children
    (2016-01-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; OKTEM, Faruk; Ergen, Hayriye Arzu; Dogan, Akif Nuri; Uzuner, SELÇUK; Vehapoglu, Aysel; Yazici, MEBRURE; UZUNER, SELÇUK; VEHAPOĞLU TÜRKMEN, AYSEL; YAZICI, MEBRURE
    Background: Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease. Autoinflammatory disorders are characterized by exaggerated immune system responses. Neutrophils and their byproduct, myeloperoxidase, are important components of the innate immune system. In the present study, we searched for myeloperoxidase gene polymorphisms in FMF patients. Methodology/Principal Findings: We evaluated 83 children diagnosed with FMF by their physicians and 93 controls without any family history of FMF. MPO gene polymorphisms were detected using polymerase chain reaction (PCR)-based methods. We genotyped all samples in terms of the -463G/A single-nucleotide polymorphism, the most extensively studied MPO polymorphism. Allelic and genotypic frequencies were calculated, and possible associations with FMF explored. The frequencies of MPO polymorphisms differed significantly between the study and control groups (P = 0.003). The AA and AG gene polymorphisms were more prevalent in the FMF group than in the controls. The A allele was more prevalent in the FMF group (P = 0.001), and the frequency of the G allele was similar between the two groups (P = 0.128). Conclusion: MPO gene polymorphisms and allelic differences may be important in the pathogenesis of FMF.
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    PublicationOpen Access
    The different cutaneous presentations in three cases of Kawasaki disease as confounding factor of diagnosis
    (2016-09-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; Uzuner, SELÇUK; Vehapoglu, Aysel; Saritas, Turkay; OKTEM, Faruk; UZUNER, SELÇUK; VEHAPOĞLU TÜRKMEN, AYSEL
    We report three paediatric cases of Kawasaki disease (KD). Erythema multiforme (EM) was the presenting cutaneous feature in two patients, with young age (43 days old), macular rash and meningitis in the third patient. Diagnosis of KD was difficult due either to initial misdiagnosis of drug eruption, incomplete presentation, or the young age of the patient. Clinicians should be aware of these cutaneous presentations to prevent KD complications.