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ÖZTURAN, ORHAN

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ORHAN
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ÖZTURAN
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    PublicationOpen Access
    Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.
    (2020-11-01T00:00:00Z) Doğan, R; Hafız, AM; Gucin, Z; Ozer, OF; Ozturan, O; Yenigun, Alper; DOĞAN, REMZI; GÜCİN, ZÜHAL; ÖZER, ÖMER FARUK; YENİGÜN, ALPER; ÖZTURAN, ORHAN
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    PublicationOpen Access
    Angiofibroma Localized in the Sphenoid Sinus
    (2017-01-01) Yenigun, ALPER; Aksoy, Fadlullah; Vural, Omer; Ozturan, ORHAN; YENİGÜN, ALPER; AKSOY, FADLULLAH; VURAL, ÖMER; ÖZTURAN, ORHAN
    Juvenile nasopharyngeal angio-broma is the most common benign tumor of the nasopharynx with complaints of unilateral nasal obstruction and recurrent nosebleeds in the young male population. Despite being a benign tumor, it can be aggressively destructive in surrounding tissues and bones by acting locally. (e gold standard treatment method is the surgical excision of the tumor. (is case report is a case of angio-broma, a 32-year-old asymptomatic male patient with no evidence of clinical signs and endoscopic examination, which is recognized as a localized vascular mass lesion in the right sphenoid sinus on the cranial MR imaging. We prepared this case report that may represent an angio-broma localized only within the sphenoid sinus which is very rare in the literature.
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    PublicationOpen Access
    Connecticut (CCCRC) Olfactory Test: Normative Values in 426 Healthy Volunteers
    (2014-01-01) VEYSELLER, Bayram; OZUCER, Berke; KARAALTIN, Aysegul Batioglu; YILDIRIM, Yalcin; DEGIRMENCI, NAZAN; AKSOY, Fadlullah; ÖZTURAN, ORHAN; DEĞİRMENCİ, NAZAN; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
    Application of Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test to healthy Turkish volunteers, obtain normative data set and analyse the role of age, sex and smoking on olfactory scores. The present study was conducted at Bezmialem Vakif University, Department of Otorhinolaryngology. Total of 426 healthy volunteers were subjected to CCCRC olfactory test which consists of n-butanol smell threshold test and smell identification test. Olfactory function score was assessed (0: worst score; 7: best score) and mean scores were calculated. Mean age was (36.7 ± 11.1; range, 17–68). 46.2 % of the subjects were male and 53.8 % were female; 37.1 % were smokers and 62.9 % were nonsmokers. Mean n-butanol threshold score was 6.36 out of 7, mean identification score was 6.34 and mean total score was 6.35. According to CCCRC score: there were no anosmic individuals, 0.5 % were severely hyposmic, 2.6 % were moderately hyposmic,15.3 % were mildly hyposmic and 81.6 % were normosmic. CCCRC olfactory test is cost-effective, simple and practical. It can be easily applied in clinical settings. The CCCRC olfactory test is appropriate for assessment of olfactory function: Turkish population is familiar in terms of the odors used in CCCRC test. The power of this study is that it provides a normative data set against which many factors can be compared.
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    PublicationOpen Access
    Association of accessory sphenoid septa with variations in neighbouring structures
    (2017-01-01) AKSOY, FEYZA MÜBERRA; ÖZTURAN, ORHAN; GOKTAS, S.S.; YENİGÜN, ALPER; YENİGÜN, ALPER; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
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    Yutma Bozukluğu Olan Çocuklarda Beslenme Türüne Göre Ebeveynlerin Stres ve Yaşam Kalitesi Düzeyleri
    (2022-11-05) Pehlivan S.; Tanrıverdi M.; Çalım Ö. F.; Özturan O.; TANRIVERDİ, MÜBERRA; ÇALIM, ÖMER FARUK; ÖZTURAN, ORHAN
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    PublicationOpen Access
    Otoacoustic Emission Responses of the Cochlea to Acute and Total Ischemia
    (2013-12-01) Yildirim, YAVUZ SELİM; AKSOY, Fadlullah; Ozturan, ORHAN; VEYSELLER, Bayram; DEMIRHAN, Hasan; YILDIRIM, YAVUZ SELİM; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
    In the present experimental study, we sought to monitor distortion product otoacoustic emissions (DPOAEs) as an indicator of cochlear function, after sudden, total, and irreversible interruption of cochlear blood flow, to provide information on the time course of cochlear response to ischemia. Twenty rats with normal hearing function were included. Complete and abrupt ischemia was provided by decapitation. DPOAEs at 3–8 kHz frequencies were recorded at baseline and exactly every consecutive minute after decapitation, until emissions in all frequencies disappeared completely. Mean DPOAE values decreased significantly and progressively after decapitation for all frequencies. The mean duration of emissions was 8.20 ± 1.96 min (minimum 3 min, maximum 11 min). The longest durations of DPOAEs were observed with 4 and 5 kHz frequencies, and 3 and 6 kHz had the shortest durations. The outer hair cells exposed to acute ischemia seem to exhibit a rapid functional loss; thus, cautious handling of the cochlear vasculature and surrounding structures is necessary in surgical interventions. Additionally, our results provide some idea of the normal tolerance range of the cochlea to ischemia, which could be useful for future studies
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    Key stone plasty and asymmetric hump resection in crooked nose deformity
    (2022-09-01) Balikci H.; YENİGÜN A.; ÇELİK İ.; AKSOY F.; DOĞAN R.; ÖZTURAN O.; YENİGÜN, ALPER; ÇELİK, İSMAİL; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN
    © 2022 Elsevier Inc.Objective: The aim of this study is to propose a new approach in crooked nose deformity with key-stone plasty and asymmetric hump resection. Method: Twelve patients with crooked nose deformities were operated using the open rhinoplasty technique. Our method, unlike other methods, has two different steps. Following asymmetric hump resection, cartilaginous and osseous septum were cut separated at the key stone area or more caudally and fix the septum with sutures again by allowing them to slide over each other in a way that directs the septum to the midline. If there is an inability to reveal the septum, we apply a longer spreader graft to the cartilage septum side. Results: The mean ages were 27.4 years. The mean follow-up time of the patients was 19.1 months. No complications were observed due to this technique. This technique was effective in the treatment of all our patients with crooked nose deformities. Conclusion: A novel surgical approach with key-stone plasty and asymmetric hump resection method was proposed in crooked nose deformity with a video animation.
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    PublicationOpen Access
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    PublicationOpen Access
    Dry Eye and Dry Nose Caused by the Effect of Allergic Rhinitis on Tear and Nasal Secretion Osmolarity.
    (2020-03-17T00:00:00Z) Elbay, A; Yenigun, A; Ozturan, O; Bayraktar, H; Ozer, Ömer Faruk; Dogan, R; YENİGÜN, ALPER; ELBAY, AHMET; ÖZDEM, ABDULLAH; ÖZER, ÖMER FARUK; DOĞAN, REMZI; ÖZTURAN, ORHAN
    Objective: Allergic rhinitis is a type 1 hypersensitivity reaction of immunoglobulin E in the rhino-ocular mucosa. This study was planned to demonstrate in patients with allergic rhinitis to evaluate changes in tear, nasal secretions, and blood osmolarity compared to healthy individuals. Method: Forty allergic rhinitis patients, 25 patients with acute upper respiratory tract infections, and 26 healthy participants were included in the study. Positive patients with allergic symptoms and skin prick test results were included in the allergic rhinitis group. Tear, nasal secretion, and blood osmolarity values were examined for the 3 groups. Result: In patients with allergic rhinitis, tear and nasal secretion osmolarity values were significantly higher in patients with acute upper respiratory tract infections and those of the healthy participants (P ¼ .001, P ¼ .038). In blood osmolarity measurements, there was no statistical difference between the groups (P ¼ .489). In patients with allergic rhinitis, Schirmer test results were significantly shorter than patients who had acute upper respiratory tract infection and those of the healthy participants (P ¼ .001, P ¼ .001). Patients with allergic rhinitis and acute upper respiratory tract infections had significantly shorter Schirmer test results than in healthy participants (P ¼ .001, P ¼ .001). Conclusion: Tear osmolarity was increased in allergic rhinitis patients, and this was thought to lead to dry eye findings. In the presence of allergic rhinitis, nasal secretions were found more hyperosmolar than tears. Nasal secretion osmolarity was higher in allergic rhinitis patients than in patients with acute upper respiratory tract infections and control group.
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    PublicationOpen Access
    Effect of Radiofrequency on DNA Damage and Oxidative Status in Patients with Turbinate Hypertrophy.
    (2019-11-01) Tugrul, S; Koçyiğit, A; Senturk, E; Doğan, Remzi; Eren, SB; Ozturan, ORHAN; Kesgin, S; ŞENTÜRK, EROL; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; EREN, SABRİ BAKİ; ÖZTURAN, ORHAN; KOÇYİĞİT, ABDÜRRAHİM
    The radiofrequency devices that are used generate radiofrequency in the frequency range of 1.5 and 2.5 MHz. This study aims to demonstrate whether systematic oxidative status and DNA are influenced in this frequency range. In study, 27 patients who received radiofrequency treatment on inferior turbinate as they were diagnosed with inferior turbinate hypertrophy. DNA damage was assessed by alkaline comet assay in peripheral lymphocyte cells. Plasma levels of total antioxidant status (TAS), total oxidative status (TOS) were determined by using an automated measurement method and oxidative stress index (OSI) was calculated (OSI was calculated as: OSI = (TOS/TAS) × 100). There were increased in the OSI and TOS values on days 1 and 15 as compared to the samples taken before the radiofrequency administration. Significant decreases were seen in TAS values on days 1 and 15. As for the DNA damage, no significant differences were found on day 15 compared to the preoperative values even though there was a statistically insignificant increase on day 1. Administration of radiofrequency radiation on inferior turbinates results in increased oxidative stress in the acute period and a decrease in the anti-oxidative system. Although this effect causes a slight increase in the DNA damage in the early post-operative period, the damage is restored to the pre-operative levels on day 15. Therefore, we believe that a more conservative approach should be selected for radiofrequency treatment instead of using it routinely.