Person: ÖZTURAN, ORHAN
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Publication Open Access Angiofibroma Localized in the Sphenoid Sinus(2017-01-01) Yenigun, ALPER; Aksoy, Fadlullah; Vural, Omer; Ozturan, ORHAN; YENİGÜN, ALPER; AKSOY, FADLULLAH; VURAL, ÖMER; ÖZTURAN, ORHANJuvenile nasopharyngeal angio-broma is the most common benign tumor of the nasopharynx with complaints of unilateral nasal obstruction and recurrent nosebleeds in the young male population. Despite being a benign tumor, it can be aggressively destructive in surrounding tissues and bones by acting locally. (e gold standard treatment method is the surgical excision of the tumor. (is case report is a case of angio-broma, a 32-year-old asymptomatic male patient with no evidence of clinical signs and endoscopic examination, which is recognized as a localized vascular mass lesion in the right sphenoid sinus on the cranial MR imaging. We prepared this case report that may represent an angio-broma localized only within the sphenoid sinus which is very rare in the literature.Publication Open Access Connecticut (CCCRC) Olfactory Test: Normative Values in 426 Healthy Volunteers(2014-01-01) VEYSELLER, Bayram; OZUCER, Berke; KARAALTIN, Aysegul Batioglu; YILDIRIM, Yalcin; DEGIRMENCI, NAZAN; AKSOY, Fadlullah; ÖZTURAN, ORHAN; DEĞİRMENCİ, NAZAN; AKSOY, FADLULLAH; ÖZTURAN, ORHANApplication of Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test to healthy Turkish volunteers, obtain normative data set and analyse the role of age, sex and smoking on olfactory scores. The present study was conducted at Bezmialem Vakif University, Department of Otorhinolaryngology. Total of 426 healthy volunteers were subjected to CCCRC olfactory test which consists of n-butanol smell threshold test and smell identification test. Olfactory function score was assessed (0: worst score; 7: best score) and mean scores were calculated. Mean age was (36.7 ± 11.1; range, 17–68). 46.2 % of the subjects were male and 53.8 % were female; 37.1 % were smokers and 62.9 % were nonsmokers. Mean n-butanol threshold score was 6.36 out of 7, mean identification score was 6.34 and mean total score was 6.35. According to CCCRC score: there were no anosmic individuals, 0.5 % were severely hyposmic, 2.6 % were moderately hyposmic,15.3 % were mildly hyposmic and 81.6 % were normosmic. CCCRC olfactory test is cost-effective, simple and practical. It can be easily applied in clinical settings. The CCCRC olfactory test is appropriate for assessment of olfactory function: Turkish population is familiar in terms of the odors used in CCCRC test. The power of this study is that it provides a normative data set against which many factors can be compared.Publication Open Access Association of accessory sphenoid septa with variations in neighbouring structures(2017-01-01) AKSOY, FEYZA MÜBERRA; ÖZTURAN, ORHAN; GOKTAS, S.S.; YENİGÜN, ALPER; YENİGÜN, ALPER; AKSOY, FADLULLAH; ÖZTURAN, ORHANPublication Open Access The Need for Completion Thyroidectomy in Cases of Differentiated Thyroid Cancer(2017-02-01) VEYSELLER, BAYRAM; ÖZTURAN, ORHAN; YENİGÜN, ALPER; MERİÇ HAFIZ, AYŞENUR; AKSOY, MEHMET FADLULLAH; YENİGÜN, ALPER; AKSOY, FADLULLAH; ÖZTURAN, ORHANThere are no definitive criteria for the presence of malignancy in the opposite lobe in cases of unilateral lobectomy due to a thyroid mass in which the malignancy was diagnosed histologically. Study design is retrospective, cross sectional study. The present study included patients who underwent a lobectomy in our clinic between 2001 and 2016 with an initial diagnosis of atypia with undetermined significance or suspected malignancy according to fine-needle aspiration biopsy and adult patients who received a thyroidectomy based on thyroid cancer detected in pathological examinations. Tumor histopathological diagnosis, tumor size, and capsular, vascular, or lymphatic invasion were assessed in patients who received thyroid lobectomy. The presence of a multifocal tumor (52.3%) significantly increased the risk of malignancy in the opposite lobe over the risk association with a unifocal tumor (8.9%; p < 0001). In patients with a tumor diameter greater than 4 cm (83.3%), the risk of malignancy in the opposite lobe was higher than that in patients with a tumor diameter less than 4 cm (22.3%; p < 0.001). Significant differences were not observed between groups with and without vascular or capsular invasion of the opposite lobe (p = 0.913 and p = 0.840, respectively). We determined risk factors for the presence of multifocal disease in unilateral lobectomy materials; an aggressive tumor subtype and a size larger than 4 cm are the most important factors that increase the risk of malignancy in the opposite lobe. Level of evidence Level 4-Case-control studies.Publication Open Access Otoacoustic Emission Responses of the Cochlea to Acute and Total Ischemia(2013-12-01) Yildirim, YAVUZ SELİM; AKSOY, Fadlullah; Ozturan, ORHAN; VEYSELLER, Bayram; DEMIRHAN, Hasan; YILDIRIM, YAVUZ SELİM; AKSOY, FADLULLAH; ÖZTURAN, ORHANIn the present experimental study, we sought to monitor distortion product otoacoustic emissions (DPOAEs) as an indicator of cochlear function, after sudden, total, and irreversible interruption of cochlear blood flow, to provide information on the time course of cochlear response to ischemia. Twenty rats with normal hearing function were included. Complete and abrupt ischemia was provided by decapitation. DPOAEs at 3–8 kHz frequencies were recorded at baseline and exactly every consecutive minute after decapitation, until emissions in all frequencies disappeared completely. Mean DPOAE values decreased significantly and progressively after decapitation for all frequencies. The mean duration of emissions was 8.20 ± 1.96 min (minimum 3 min, maximum 11 min). The longest durations of DPOAEs were observed with 4 and 5 kHz frequencies, and 3 and 6 kHz had the shortest durations. The outer hair cells exposed to acute ischemia seem to exhibit a rapid functional loss; thus, cautious handling of the cochlear vasculature and surrounding structures is necessary in surgical interventions. Additionally, our results provide some idea of the normal tolerance range of the cochlea to ischemia, which could be useful for future studiesPublication Open Access Olfactory Dysfunction and Olfactory Bulb Volume Reduction in Patients with Leprosy(2012-09-01) VEYSELLER, Bayram; AKSOY, Fadlullah; Yildirim, YAVUZ SELİM; ACIKALIN, R. Murat; GURBUZ, Defne; Ozturan, ORHAN; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHANTo ascertain the level and rate of olfactory dysfunction in patients with leprosy and to determine whether olfactory bulb volume is affected by the pathophysiology. Olfactory bulb (OB) volume, measured using magnetic resonance imaging (MRI), was compared in 15 patients with leprosy and 15 healthy controls. All of the participants were evaluated using a detailed history to identify the probable causes of the smell dysfunction. Those who had a disease other than leprosy that may have caused the smell dysfunction were excluded from the study. OB volumes were calculated by manually tracing the OB on coronal sections. Orthonasal olfaction testing was used to assess smell function. The orthonasal olfaction testing indicated that all patients with leprosy were anosmic or severely hyposmic. The smell function test indicated that the OB volume of the patient group was significantly lower than that of the control group. No within-group difference was detected between right and left OB volume in either group. The patients in the leprosy group were severely hyposmic or anosmic and their olfactory bulb volume was significantly lower than that of the control group. To our knowledge, this study is the first to show a reduction in olfactory bulb volume among leprosy patients.Publication Open Access Use of Topical Tranexamic Acid to Reduce Drainage Output After Thyroidectomy(2022-04-01T00:00:00Z) AKSOY, FADLULLAH; YENİGÜN, ALPER; YENİGÜN, Vildan Betül; Goktas, Seda Sezen; Ozdem, Abdullah; DOĞAN, Remzi; ÖZTURAN, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; YENİGÜN, VILDAN BETÜL; ÖZDEM, ABDULLAH; DOĞAN, REMZI; ÖZTURAN, ORHANObjective: Thyroid surgery is one of the frequent surgeries in daily operation schedules more often since the thyroid gland is very vascular Hematomas after thyroidectomy may cause airway obstruction, which is life-threatening and requires immediate surgical intervention. Therefore, many hemostatic devices and methods have been developed. Tranexamic acid is a synthetic lysine analog with low molecular weight. This study was planned to demonstrate the effect of intraoperative topical tranexamic acid on postoperative drainage output for thyroid surgery.Publication Open Access Is Transnasal Endoscopic Examination Necessary Before and After Adenoidectomy?(2014-01-01) Yildirim, YAVUZ SELİM; Apuhan, Tayfun; AKSOY, Fadlullah; VEYSELLER, Bayram; ÖZTURAN, ORHAN; YILDIRIM, YAVUZ SELİM; AKSOY, FADLULLAH; ÖZTURAN, ORHANThe present study aimed to investigate the amount of residual adenoid tissue following the conventional adenoidectomy as compared with preoperative values. A total of 32 girls and 44 boys (range, 3–15 years) in whom adenoidectomy procedure was planned were included in the study. Adenoid tissue sizes before adenoidectomy and residual tissue sizes after conventional curettage adenoidectomy were measured by transnasal endoscopic examination and were recorded. Adenoid tissue size before and after adenoidectomy was compared. The mean age of the patients was 7.7 years (range, 3–15 years). Before adenoidectomy grade 4 adenoid tissue was noted in 43.4% (n = 33), grade 3 was noted in 28.9% (n = 22), grade 2 was noted in 25% (n = 19), and grade 1 was noted in 2.6% (n = 2) of the patients. Following adenoidectomy, no significant difference was noted with respect to residual adenoid tissue sizes of grade 4 and grade 3 patients (P = 0.75, P = 0.76). Transnasal endoscopic examination is suggested to be the most appropriate method to assess the amount of residual adenoid tissue after conventional curettage adenoidectomy. The residual adenoid tissue with the help of a microdebrider in case of a large residual adenoid tissue located in the choana are necessary for complete adenoidectomyPublication Open Access Investigation of the role of major respiratory viruses in the aetiology of nasal polyps using polymerase chain reaction technique(2014-04-01) YENIGUN, A.; AKSOY, FEYZA MÜBERRA; DOGAN, REMZİ; Yilmaz, F.; Ozturan, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN; YENİGÜN, VILDAN BETÜLObjective: We aimed to identify the role of major respiratory viruses in the aetiology of human nasal polyps using polymerase chain reaction technique. Methods: Thirty patients with nasal polyps and a group of 20 healthy patients (control group) were included in this study. Mucosa was obtained from the polyps of patients with nasal polyposis and from the middle turbinate of the control group patients by means of biopsy. The samples were stored at -80 °C until molecular analysis by polymerase chain reaction was carried out. Results: In the control group, the human coronavirus and human rhinovirus were diagnosed in one of the patients and the human respiratory syncytial virus in another. In the group with nasal polyposis, the influenza B virus was identified in one of the patients and the human coronavirus in another. Conclusion: The results did not demonstrate a statistically significant relationship between nasal polyposis and respiratory viruses.Publication Open Access An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats(2015-12-01) TUGRUL, Selahattin; Dogan, REMZİ; AKSOY, Fadlullah; VEYSELLER, Bayrann; Ozer, Omer Faruk; PEKTAS, Alev; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; ÖZER, ÖMER FARUKObjectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.