Person: KARTAL, MURAT
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Publication Metadata only Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro(2011-04-01T00:00:00Z) HOSEK, Jan; BARTOS, Milan; CHUDIK, Stanislav; DALL'ACQUA, Stefano; INNOCENTI, Gabbriella; Kartal, MURAT; KOKOSKA, Ladislav; KOLLAR, Peter; KUTIL, Zsofia; LANDA, Premysl; MAREK, Radek; ZAVALOVA, Veronika; ZEMLICKA, Milan; SMEJKAL, Karel; KARTAL, MURATCudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models: Thus, 1 was identified as a:potent inhibitor of tumor necrosis factor a (TNF alpha) gene expression and secretion by blocking the translocation of nuclear factor kappa B (NF-kappa B) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappa B activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound Cads as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreament of cells by 1 shifted the peak in an regulatory gene zinc finger protein 36 (ZFP36) expression assay. This natural product has noticeable anti-inflammatory properties suggesting that 1 potentially could be Used for development as a nonsteroidal anti inflammatory drug leadPublication Metadata only Selective Cholinesterase Inhibitors from Buxus sempervirens L. and their Molecular Docking Studies(2011-12-01T00:00:00Z) Orhan, Ilkay E.; KHAN, Mahmud T. H.; Erdem, Sinem A.; Kartal, MURAT; Sener, Bilge; KARTAL, MURATIn this work, two alkaloids namely (+)-buxabenzamidienine (1) and (+)-buxamidine (2) were isolated from Buxus sempervirens, using bioassay-guided fractionation and isolation method. Their acetyl-(AChE) and butyrylcholinesterase (BChE) inhibitory activities were studied and the compounds were found to be quite selective inhibitors of AChE. IC50 values of compound 1 for electric eel AChE and horse BChE were 0.787 and 7.68 mM, respectively; while the corresponding IC50 of compound 2 were 1.70 and 549.98 mM, respectively. Theoretical (quantum mechanical, homology modelling and docking) calculations were performed in order to explain their interactions with different AChE (electric eel and human) and BChE (horse and human). The x-ray crystal structures of electric eel AChE, human AChE, human BChE and a model of horse BChE constructed by homology with human BChE were used for docking of compounds 1 and 2. Density functional theory (DFT) calculations of the compounds were performed at the B3LYP/6-31G** level using the program Spartan (TM), and their HOMO and LUMO energy levels were calculated. Docking studies exhibited that compound 1 interacts with the acyl-binding pocket of the active site gorge of huAChE, and including several other hydrophobic interactions.Publication Metadata only Mersin Yaprağı Uçucu Yağı(2019-01-01T00:00:00Z) Kartal, Murat; KARTAL, MURATPublication Metadata only Analysis of pomegranate juice components in rat corpora cavernosal relaxation(2014-03-01T00:00:00Z) OZTEKIN, C. V.; Gur, S.; Abdulkadir, N. A.; Kartal, MURAT; KARABAKAN, M.; AKDEMIR, A. O.; GOKKAYA, C. S.; CETINKAYA, MURAT; KARTAL, MURAT; ÇETİNKAYA, MURATThis study evaluated the action of pomegranate juice (PJ) and its five principal phenolic constituents on rat corpus cavernosum smooth muscle (CCSM). Isometric tension studies were performed after precontraction with phenylephrine in CCSM from rats. Relaxant responses to PJ and its constituents ellagic acid (EA), chlorogenic acid, caffeic acid, cumaric acid and rutin were investigated. PJ and EA caused CCSM relaxations (94.1 +/- 3.7 and 51.3 +/- 9.9%), while others induced limited relaxant responses. EA response was not inhibited by L-N(G)-nitroarginine methyl ester (100 mu M) and 1H-[1,2,4]-oxadiazolo[4,3-a] quinoxalin-1-one (1 mu M). Tetraethylammonium (100 mu M) and apamin (10 mu M) and nifedipine (10 mu M) inhibited EA-induced relaxations at 10(-3) M by 84%, 82% and 78%, respectively. Glibenclamide (10 mu M) inhibited EA response (97%, 100 mu M). PJ-induced relaxation was not altered by several inhibitors. EA was estimated to be responsible for 13.3% of relaxation caused by PJ. Our study demonstrated that PJ and EA-induced marked relaxations in CCSM. The opening of Ca(2 + )-activated K + channels and the inhibition of Ca(2 + )-channels regulate the relaxation by EA, but not PJ. EA has a minor contribution to the marked relaxation obtained by PJ, suggesting the presence of other PJ constituents, which induce nitric oxide-independent corporal relaxation. Further studies are needed to examine the potential of PJ in combination with a PDE5 inhibitor in ED.Publication Metadata only Inhibitory Effects of Various Essential Oils and Individual Components against Extended-Spectrum Beta-Lactamase (ESBL) Produced by Klebsiella pneumoniae and Their Chemical Compositions(2011-10-01T00:00:00Z) Orhan, Ilkay Erdogan; Ozcelik, Berrin; Kan, Yuksel; Kartal, MURAT; KARTAL, MURATIn the current study, in vitro inhibitory activity of several essential oils obtained from the cultivated plants, Foeniculum vulgare, Mentha piperita and M. spicata, Ocimum basilicum, Origanum majorana, O. onites, O. vulgare, Satureja cuneifolia, and a number of individual essential oil components of terpene and aromatic types were screened against 10 isolated strains of Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL) enzyme, which makes this microorganism quite resistant against the antibiotics: trimetoprime-sulfametoksazol, sulbactam-ampicilin, clavulonate-amoxicilin, ceftriaxon, cefepime, imipenem, ceftazidime, tobramicine, gentamisine, ofloxacin, and ciprofloksasin. All of the essential oils and the components exerted a remarkable inhibition ranging between 32 and 64 mu g/mL against all of these strains as strong as the references (ampicilin and oflaxocin) inhibiting at 32 mu g/mL. Besides, chemical compositions of the essential oils were elucidated by gas chromatography-mass spectrometry (GC-MS). The essential oils and the pure components widely found in essential oils screened herein have shown remarkable inhibition against ESBL-producing K. pneumoniae strains, which leads to the suggestion that they may be used as food preservatives for this purpose.Publication Metadata only Profiling of cholinesterase inhibitory and antioxidant activities of Artemisia absinthium, A. herba-alba, A. fragrans, Marrubium vulgare, M. astranicum, Origanum vulgare subsp glandulossum and essential oil analysis of two Artemisia species(2010-11-01T00:00:00Z) Orhan, I. Erdogan; BELHATTAB, R.; Senol, F. S.; Gulpinar, A. R.; Hosbas, S.; Kartal, MURAT; KARTAL, MURATIn the current study, cholinesterase inhibitory and antioxidant activities of the acetone and ethanol extracts of Artemisia absinthium, A. herba-alba, A. fragrans, Marrubium vulgare, M. astranicum, and Origanum vulgare var. glandulossum along with the essential oil of A. absinthium were investigated. Cholinesterase inhibitory activity was determined against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at 25, 50, and 100 mu g/mL using an ELISA microplate reader. Antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity, ferrous ion-chelating ability, and ferric-reducing antioxidant power (FRAP) tests at 250, 500, and 1000 mu g/mL. Among the extracts, the highest inhibition against AChE (76.30 +/- 0.18% at 100 mu g/mL) and BChE (83.51 +/- 1.27% at 50 mu g/mL) was caused by the acetone extract of M. vulgare. The acetone extract of O. vulgare var. glandulossum showed a greater FRAP than that of the reference (chlorogenic acid). Essential oil compositions of A. absinthium and A. herba-alba were also analyzed by GC-MS. (C) 2010 Elsevier B.V. All rights reserved.Publication Metadata only Alzheimer Hastalığı ve Doğal Kaynaklı Bileşikler(2021-12-01T00:00:00Z) Ulusoy, Şeyma; Kartal, Murat; İnal, Ebrar; ULUSOY, ŞEYMA; KARTAL, MURAT; İNAL, EBRARPublication Metadata only Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids(2011-04-01T00:00:00Z) Ozcelik, Berrin; Kartal, MURAT; Orhan, Ilkay; KARTAL, MURATMaterials and methods: Antiviral activity of the compounds was tested against DNA virus herpes simplex type 1 and RNA virus parainfluenza (type-3). Cytotoxicity of the compounds was determined using Madin-Darby bovine kidney and Vero cell lines, and their cytopathogenic effects were expressed as maximum non-toxic concentration. Antibacterial activity was assayed against following bacteria and their isolated strains: Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis, although they were screened by microdilution method against two fungi: Candida albicans and Candida parapsilosis.Publication Metadata only The Consumption Preferences on the Use of Herbal Products in Turkey and Opinions on Pharmacists(2017-12-01T00:00:00Z) EKER, HASAN HÜSEYİN; eriş, canan; KARTAL, MURAT; ABUDULİ, MAİHEBURETİ; ATMACA, SEDEF; TOPCU, GÜLAÇTI; ŞAHİNÖZ, SAİME; KARTAL, MURATPublication Metadata only Effects of Echinacea extract on the performance, antibody titres, and intestinal histology of layer chicks(2010-01-01T00:00:00Z) Gurbuz, E.; Balevi, T.; Kurtoglu, V.; Coskun, B.; Oznurlu, Y.; Kan, Y.; Kartal, MURAT; KARTAL, MURAT1. This research was conducted to determine the effect of diet supplementation with Echinacea extract (cichoric acid) on the growth performance, antibody titres and intestinal tissue histology of layer chicks. 2. White, 1-d-old, Hy-Line hybrid chicks (n = 540) were divided into three treatments, each consisting of 6 groups of 30 chicks (n = 180): (1) control; (2) 2 center dot 5 mg/kg cichoric-acid-fed; and (3) 5 mg/kg cichoric-acid-fed. The trial lasted 60 d. 3. While the growth performance of the chicks was depressed between d 1 and 45, it was found to improve between d 45 and 60. 4. Feed consumption was lower in both of the cichoric-acid-fed groups than in the control group between d 1-15 and 15-30, but was higher between d 30 and 45. Overall, mean feed consumption did not differ between the control and cichoric-acid-fed groups during the 60 d study period. 5. During the 60 d evaluation period, live weight gain, feed utilisation rate and final live weight were higher in the control group than in both of the cichoric-acid-fed groups. 6. Antibody titres against infectious bronchitis and infectious bursal disease did not differ between the three groups, but those for Newcastle disease were higher in the 2 center dot 5 mg/kg cichoric-acid-fed group than in the control group after 45 d. 7. Height and width of the jejunal villus and the thickness of the muscle layer were lower in the 5 mg/kg cichoric-acid-fed group than in both the control and the 2 center dot 5 mg/kg cichoric-acid-fed groups. The height of the ileal villus was also lower in the 5 mg/kg cichoric-acid-fed group than in the other two groups. 8. Echinacea extract supplementation for layer chicks appears not to benefit growth performance and intestinal histology during the growing period.