Person: KİTİŞ, SERKAN
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Publication Open Access Comparison of the biochemical and radiological criteria for lumbar disc degeneration(2018-09-01) Seyithanoglu, MEHMET HAKAN; Kitis, SERKAN; Ozer, Omer Faruk; Kocyigit, ABDÜRRAHİM; DÜNDAR, Tolga; Papaker, Meliha Gundeg; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKAN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİMBackground: The relationship between radiological degeneration criteria on lumbar magnetic resonance imaging (MRI) and both the keratan sulfate (KS) and chondroitin sulfate (ChS) levels was examined in disc material taken from patients undergoing lumbar disc herniation (LDH) surgery. To examine whether the biochemical and radiological degeneration criteria testing the reliability of radiological degeneration findings agreed and to evaluate the contribution of the KS/ChS ratio to disc form (protruding or extruding).Publication Open Access Spontaneous Resolution of Paraparesis Because of Acute Spontaneous Thoracolumbar Epidural Hematoma(2012-01-01) GUNDAG, MELİHA; DOGAN, K.; Kitis, SERKAN; Ozkan, N.; GUNDAG, MELİHA; SEYİTHANOĞLU, MEHMET HAKAN; KİTİŞ, SERKANSymptomatic spontaneous spinal epidural hematoma(SSEH) is an uncommon cause of cord compression that commonly is considered an indication for emergent surgical decompression. We aimed to investigate a patient with a SSEH that completely resolved clinically and radiographically, without surgical treatment. The patient presented three days after the sudden onset of back pain, numbness, and weakness. Magnetic Resonance Imaging (MRI) revealed a posterior thoracolumbar epidural hematoma extending from the level of T10 to L2 with significant cord compression. Decompression was recommended but he refused surgery and was managed conservatively. One month later weakness totally recovered and hematoma was absent on MRI.Publication Open Access The relationship of erythropoietin receptor expression and prognosis in glioblastoma multiforme patients.(2018-04-01) ÇEVIK, Serdar; Kitis, SERKAN; EVRAN, Şevket; AKKAYA, Enes; TOSUNER, ZEYNEP; HANIMOGLU, Hakan; KİTİŞ, SERKAN; TOSUNER, ZEYNEPBackground: Glioblastoma multiforme (GBM) is the most common primary brain tumor characterized with poor prognosis and short survival. In addition to the standard treatment protocols, targeted molecular treatment options are under trial. In the recent trials, erythropoietin and erythropoietin receptor were found to be linked with the progression of GBM cells. Aim: In this study, we compared the expression of EPOR with survival in GBM patients with mortality. Materials and Methods: Twenty‑six patients operated for GBM in 2012–2014 were enrolled in this study. Tumor tissues were stained with EPOR, epidermal growth factor receptor, vascular endothelial growth factor, and assigned as (1+), (2+), and (3+) according to their immunohistochemical staining levels. The average postoperative follow‑up time was 9.3 months. Kaplan–Meier’s survival test and Spearman’s correlation test were used in statistical analysis. Results: EPOR 1(+) stained group showed a median survival of 8 months (95% confidence interval [CI]: 0.954–15.046). EPOR 2(+) stained group showed a median survival of 6 months (95% CI: 2.901–9.090) EPOR 3(+) stained group showed a median survival of 2 months (95% CI: 0.400–3.600). (Kaplan–Meier P = 0.002). Conclusion: These results portrayed that EPOR staining levels were inversely proportional with average survival time. In the future, specific inhibitors of this molecule could be used to form a novel treatment option for GBM.