Person: KARATOPRAK, CUMALİ
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Publication Metadata only Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women(2022-01-01T00:00:00Z) ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; Güler, Eray Metin; Gülen, Bedia; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFABackground: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = -0.725; p < 0.001, r = -0.720; p < 0.001, r = -0.238; p = 0.037, r = -0.705; p < 0.001, respectively). Discussion: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future.Publication Metadata only Protective effect of dexpanthenol against nephrotoxic effect of amikacin: An experimental study(2017-05-01) Dogan, ELİF ECE; ERKOC, Reha; EKINCI, Iskender; HAMDARD, Jamshid; DONER, Baris; KARATOPRAK, CUMALİ; Coban, GANİME; Ozer, Omer Faruk; Kazancioglu, RÜMEYZA; DOĞAN, ELİF ECE; KARATOPRAK, CUMALİ; ÇOBAN, GANİME; ÖZER, ÖMER FARUK; KAZANCIOĞLU, RÜMEYZABackground: Amikacin has the largest spectrum among aminoglycosides, its nephrotoxic effect limits its utilization. Our purpose in this study is to review the protective effect of dexpanthenol against the nephrotoxic effect of amikacin, accompanied with histopathological and biochemical parameters.Publication Metadata only The levels of β-thromboglobulin in female rheumatoid arthritis patients as activation criteria.(2013-05-01) ABANONU, Gul Babacan; UYAR, S; PEHLEVAN, SM; OKUROGLU, N; DEMIRTUNÇ, R; KARATOPRAK, CUMALİPublication Metadata only A case of rhabdomyolysis complicated with acute renal failure after resumption of fenofibrate therapy: a first report.(2013-05-01) KıSKAÇ, MUHARREM; ZORLU, MEHMET; CAKIRCA, MUSTAFA; Karatoprak, CUMALİ; PERU, C; ERKOÇ, R; YAVUZ, E; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇAKIRCA, MUSTAFA; KARATOPRAK, CUMALİPublication Metadata only DEMOGRAPHIC EVALUATION OF ATTEMPTED SUICIDE BY DRUG OVERDOSE IN ISTANBUL(2015-01-01) Karatoprak, CUMALİ; KARABULUT, Laika; KAYA, Bilgivar; ALTINDAL, Mahmut; UGURLUKISI, Bilal; KILICASLAN, Mehmet Hanifi; ABANONU, Gul Babacan; Cetin, GÜVEN; CIKRIKCIOGLU, Mehmet Ali; KARATOPRAK, CUMALİ; ÇETİN, GÜVENIntroduction: In recent years in our country, as well as all over the world, the frequency of attempted suicide by drug overdose is very noticeable. In our study, we aimed to identify general characteristics of patients with drug-attempted suicide, their drug preferences, and the ways in which they obtained the drugs. We conducted an observational study of patients who came to the emergency department with an indication of drug use for attempted suicide during the one-year.Publication Metadata only ABO and Rh Blood Group Distribution in Istanbul Province(2015-01-01T00:00:00Z) SALDUZ, ZEYNEB IREM YUKSEL; ÇETİN, GÜVEN; KARATOPRAK, CUMALİ; ÖZDER, ACLAN; ÇETİN, GÜVEN; KARATOPRAK, CUMALİ; ÖZDER, ACLANPublication Metadata only Pott-s disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy(2013-11-01) KARATOPRAK, CUMALİ; ZORLU, MEHMET; KıSKAÇ, MUHARREM; CAKIRCA, MUSTAFA; YAVUZ, E; Cetin, GÜVEN; CIKRIKCIOGLU, MA; ZORLU, MEHMET; KISKAÇ, MUHARREM; KARATOPRAK, CUMALİ; ÇAKIRCA, MUSTAFA; ÇETİN, GÜVENPublication Metadata only Evaluation of clinical and laboratory findings with JAK2 V617F mutation as an independent variable in essential thrombocytosis.(2014-10-01) Cetin, GÜVEN; OZKAN, T; TURGUT, SEDA; Ali, Cikrikcioglu; CEM, AR M; AYER, M; UNLU, A; KARATOPRAK, CUMALİ; SEKIN, Y; ÇETİN, GÜVEN; TURGUT, SEDA; ÇELİK, ŞENGÜL; KARATOPRAK, CUMALİPublication Metadata only Factor XI deficiency diagnosed following use of adalimumab.(2014-09-01) KARATOPRAK, CUMALİ; CETIN, GÜVEN; KISKAC, MUHARREM; ZORLU, MEHMET; Rezvani, AYLİN; CIKRIKCIOGLU, MA; ÇETİN, GÜVEN; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ZORLU, MEHMET; REZVANİ, AYLİNPublication Metadata only Evaluation of the relationship between serum apelin levels and vitamin D and mean platelet volume in diabetic patients(2014-09-01) Buyukaydin, BANU; Zorlu, MEHMET; Cakirca, MUSTAFA; KESGIN, Sidika; YAVUZ, Erdinc; ARDIC, Cuneyt; Camli, AHMET ADİL; CIKRIKCIOGLU, Mehmet Ali; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇAKIRCA, MUSTAFA; KARATOPRAK, CUMALİ; BÜYÜKAYDIN, BANU; ÇAMLI, AHMET ADİLObjectives. - It was reported that Vitamin D deficiency was associated with a greater risk of cardiometabolic diseases, obesity, impaired glucose tolerance and diabetes mellitus type 2, arterial hypertension, and dyslipidemia. Apelin is an adipocytokine suspected to have a role in skeletal muscle glucose utilization and glycemic regulation which may be a promising treatment modality for diabetes. It was recently reported that increased mean platelet volume (MPV) was emerging as an independent risk factor for thromboembolism, stroke, and myocardial infarction. In patients with diabetes, MPV was higher compared with the normal glycemic controls; in addition, it has been proposed that an increase in MPV may play a role in the micro- and macro-vascular complications related to diabetes. We postulated that deficiency in Vitamin D levels might be associated with higher MPV and lower serum apelin levels leading a further increase in insulin resistance in diabetic patients. So, we aimed to investigate Vitamin D levels, MPV and serum apelin levels in diabetic patients and their correlations between each other. Materials and method. - This is a cross-sectional study design. Seventy-eight patients with Diabetes Mellitus type 2, admitted to our outpatient clinic of internal medicine department at Bezmialem Vakif University, were included in our study. Forty-one patients were female; 37 patients were male. Serum apelin levels, fasting glucose levels, urea, creatinine, triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting serum insulin level, HbAl(c), free T3, free T4, TSH, vitamin D (25-OH Vitamin D) and complete blood counts were analyzed in all subjects. Results. - Each sex was analyzed separately. We found that a positive correlation existed between serum apelin levels and BMI in female patients. (r: 0.380, P: 0.014) There was also a significant positive correlation between MPV and HbAl, and fasting glucose levels and a negative correlation between MPV and PLT. (r: 0.377, P: 0.021; r: 0.395, P: 0.014; r: 0.401, P: 0.011; respectively) We failed to show a significant relationship between serum vitamin D levels, serum apelin levels and MPV in patients with diabetes mellitus type 2. Conclusion. - We failed to show an association between vitamin D, apelin and MPV higher volumes of which may have a role in cardiovascular complications related to diabetes by increasing platelet activation. (C) 2014 Published by Elsevier Masson SAS.
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