Person: BACAKSIZ, AHMET
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Publication Open Access Ambulatory Blood Pressure Monitoring Could Unmask Hypertension in Patients with Psoriasis Vulgaris(2013-10-29) BACAKSIZ, AHMET; Erdogan, Ercan; Sonmez, Osman; Sevgili, Emrah; Tasal, Abdurrahman; ONSUN, NAHİDE; Topukcu, Bugce; Kulac, Beytullah; UYSAL, ÖMER; Goktekin, Omer; BACAKSIZ, AHMET; ONSUN, NAHIDE; UYSAL, ÖMERBackground: Psoriasis vulgaris is one of the most prevalent chronic, inflammatory skin disorders. Patients with psoriasis have excess risk of essential hypertension. Masked hypertension (MH), defined as normal office blood pressure (BP) with elevated ambulatory BP (ABPM), has been drawing attention recently due to its association with increased risk of developing sustained hypertension, cardiovascular morbidity, and mortality. The aim of this study was to investigate the prevalence of MH in psoriatic patients. Material and Methods: On hundred and ten middle-aged, normotensive, non-obese patients with psoriasis vulgaris and 110 age- and sex-matched normotensive controls were included in the study. ABPM was performed in all participants over a 24-h period. The clinical severity of the disease was determined according to current indexes. Results: The prevalence of MH among subjects with psoriasis vulgaris was 31.8% and increased compared to control subjects (p<0.01). Predictors of MH in patients with psoriasis vulgaris were detected as male sex, smoking, obesity-related anthropometric measures, and disease activity. Male sex, waist circumference, and diffuse psoriatic involvement were detected as independent predictors of MH. Conclusions: MH is prevalent in patients with psoriasis vulgaris. Assessment with ABPM and close follow-up for development of hypertension is reasonable.Publication Metadata only High SYNTAX score predicts worse in-hospital clinical outcomes in patients undergoing primary angioplasty for acute myocardial infarction(2012-12-01T00:00:00Z) Kul, Seref; Akgul, Ozgur; Uyarel, Huseyin; Ergelen, Mehmet; Kucukdagli, Okkes T.; Tasal, Abdurrahman; Erdogan, Ercan; BACAKSIZ, AHMET; Sonmez, Osman; Gul, Mehmet; Uslu, Nevzat; Goktekin, Omer; BACAKSIZ, AHMETObjective A high SYNTAX score (SXscore) is a predictor of adverse outcomes for stable and unstable coronary syndromes. We aimed to examine whether a high SXscore will determine in-hospital clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.Publication Metadata only Comparison of single-dose and repeated levosimendan infusion in patients with acute exacerbation of advanced heart failure(2014-02-01T00:00:00Z) Tasal, Abdurrahman; DEMİR, MESUT; KANADAŞI, MEHMET; BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Sahin, Durmus Yildiray; Eker, Rabia Akilli; BOZKURT, ABDİ; Acarturk, Esmeray; BACAKSIZ, AHMETBackground: Levosimendan (LS) is a novel inodilator that improves cardiac performance, central hemodynamics, and symptoms of patients with decompensated chronic heart failure. The aim of this study was to compare the effects of single and repeated LS infusion on left ventricular performance, biomarkers, and neurohormonal activation in patients with acute heart failure.Publication Open Access Valve sparing surgery in an adult patient with dextrocardia and annuloaortic ectasia(2016-01-01) Zeybek, RAHMİ; Bacaksiz, AHMET; Sharifov, RASUL; SEVGILI, Emrah; Ay, YASİN; ZEYBEK, RAHMİ; BACAKSIZ, AHMET; SHARIFOV, RASUL; AY, YASİNWe report the case of a patient with situs inversus totalis, annuloaortic ectasia complicated by aortic insufficiency and mitral regurgitation which induced congestive heart failure. Both valvular lesions were repaired physiologically using aortic root sparing Yacoub 'remodeling' technique and mitral ring annuloplasty. Valve sparing techniques can be used effectively even in patients with complicated clinical scenarios (like dextrocardia and annuloaortic ectasia) to avoid the potential risks related to prosthetic valve implantation and lifelong anticoagulation therapy.Publication Open Access The effect of the SIRT1 2827 A > G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease(2015-02-01) IZMIRLI, Muzeyyen; GOKTEKIN, Omer; Bacaksiz, AHMET; Uysal, Omer; Kilic, Ulkan; BACAKSIZ, AHMET; UYSAL, ÖMERObjective: Cardiovascular disease (CVD) is the leading cause of death in Europe. One of the candidate molecule affecting epigenetic mechanisms of CVD is the SIRT1, a subclass of sirtuins, is located on the long arm of chromosome 10 (10q21.3). Particularly, the relation between 2827 A>G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet. One of the activator of SIRT1, resveratrol, is also known as a cardioprotective molecule. On the other hand, the parameters including exercise, occupation and age affect CVD. The aim of the present study was to investigate the effect of the rs144124002 (2827 A>G) single nucleotide polymorphisms (SNP) of SIRT1 and exercise-occupation-age parameters on CVD. Methods: SNP of SIRT1 were analyzed using DNA isolation, the polymerase chain reaction (PCR) and restriction fragment length polymorphism. To do so, large cohorts of CVD patients (n=293) and healthy controls (n=117) who directed Cardiology Department of Bezmialem Vakıf University, Bezmialem Vakıf University Hospital were used. Results: In this study, when we assessed CVD and control groups about 2827 A>G polymorphism, all individuals were determined as homozygous genotype. We found a positive effect between the modifications of resveratrol, exercise, age and occupation and CVD (OR=0.17; CI 95%, 0.1-0.2; p≤0.001). Conclusion: This is the first study demonstrating the correlation between the SIRT1 rs144124002 polymorphism and CVD in Turkish population. (Anatolian J Cardiol 2015; 15: 103-6) Key words: SIRT1, resveratrol, epigenetic, polymorphism, cardiovascular diseasePublication Metadata only Assessment of the left atrial volume index and plasma NT-proANP level in patients with acute ST-elevation myocardial infarction(2013-01-01T00:00:00Z) BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Kayrak, Mehmet; Telli, Hasan Huseyin; AYHAN, SELİM; Sonmez, Osman; Alp, Ayse; Buyukbas, Sadik; BACAKSIZ, AHMETOBJECTIVES: Acute ST-elevation myocardial infarction is associated with ventricular dysfunction due to ischemia-induced progressive myocardial damage. The decrease in ventricular compliance causes left atrial dilatation and stretching of the atrial myocardium, which are the main stimuli for the secretion of atrial natriuretic peptide. The aim of this study was to evaluate left atrial dimensions and atrial natriuretic peptide levels in patients early after their first acute ST-elevation myocardial infarction and assess the probable interaction between coronary lesions and these measurements.Publication Open Access Endovascular Therapy of Acute Ischemic Stroke by Interventional Cardiologists: National Initial Experience(2013-10-29) TASAL, Abdurrahman; Bacaksiz, AHMET; VATANKULU, Mehmet Akif; SONMEZ, Osman; TURFAN, Murat; ERDOGAN, Ercan; KARADELI, Hasan Huseyin; Kolukisa, MEHMET; KUL, Seref; ALTINTAS, Ozge; Asil, TALİP; GOKTEKIN, Omer; BACAKSIZ, AHMET; KOLUKISA, MEHMET; ASİL, TALIPObjectives: We report our initial experience with thrombectomy devices in patients with acute ischemic stroke. Study design: Demographic, clinical, and angiographic findings of 19 consecutive patients (7 females and 12 males; mean age 61.4±12.5 years) with acute ischemic stroke were evaluated retrospectively. Results: The mean initial National Institutes of Health Stroke Scale (NIHSS) score was 19.5±5.6. Middle cerebral artery was the occluded artery in all of the patients (proximal occlusion in 11, distal in 8 and tandem occlusions in 7 patients). Successful revascularization was achieved in 16 patients (84%). The mean NIHSS score was 8.4±8.2 at 24 hours after the procedure, and 60% of patients showed a modified Rankin scale score of ≤2 at 90 days. New occlusion by migrated emboli was observed in 2 (11%) cases. None of the patients had experienced post-procedural symptomatic intracerebral hemorrhage; 3 patients died during the three-month follow-up. In all patients, thrombectomy was performed with retrievable Solitaire AB stent system. Conclusion: This single-center experience with mechanical thrombectomy devices demonstrated that high success rates can be achieved by experienced interventional cardiologists in equipped cath labs throughout the country.Publication Open Access SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases(2014-02-28) KILIC, Ulkan; GOK, Ozlem; Bacaksiz, AHMET; IZMIRLI, Muzeyyen; Elibol-Can, BİRSEN; Uysal, Omer; BACAKSIZ, AHMET; ELİBOL, BİRSEN; UYSAL, ÖMERCardiovascular disease (CVD), the leading cause of death worldwide, is related to gene-environment interactions due to epigenetic factors. SIRT1 protein and its downstream pathways are critical for both normal homeostasis and protection from CVD-induced defects. The aim of this study was to investigate the association between SIRT1 single nucleotide polymorphisms (SNPs) (rs7895833 A.G in the promoter region, rs7069102 C.G in intron 4 and rs2273773 C.T in exon 5 silent mutation) and SIRT1 and eNOS (endothelial nitric oxide synthase) protein expression as well as total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in CVD patients as compared to controls. The frequencies of mutant genotypes and alleles for rs7069102 and rs2273773 were significantly higher in patients with CVD compared to control group. The risk for CVD was increased by 2.4 times for rs7069102 and 1.9 times for rs2273773 in carriers of mutant allele compared with carriers of wild-type allele pointing the protective role of C allele for both SNPs against CVD. For rs7895833, there was no significant difference in genotype and allele distributions between groups. SIRT1 protein, TAS, TOS and OSI levels significantly increased in patients as compared to control group. In contrast, level of eNOS protein was considerably low in the CVD patients. An increase in the SIRT1 expression in the CVD patients carrying mutant genotype for rs7069102 and heterozygote genotype for all three SNPs was observed. This is the first study reporting an association between SIRT1 gene polymorphisms and the levels of SIRT1 and eNOS expressions as well as TAS, TOS and OSIPublication Metadata only Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure(2014-01-01T00:00:00Z) Turfan, Murat; Tasal, Abdurrahman; Erdogan, Ercan; Vatankulu, Mehmet Akif; Jafarov, Parviz; Sonmez, Osman; Ertas, Gokhan; BACAKSIZ, AHMET; Ergelen, Mehmet; Goktekin, Omer; BACAKSIZ, AHMETBackground: Acute heart failure (AHF) is a major cause of hospitalisation, morbidity and mortality worldwide. Gamma-glutamyl transferase (GGT) is an enzyme responsible for the extracellular catabolism of antioxidant glutathione and a potential risk indicator of cardiac mortality. Limited data exists on the prognostic value of circulating levels of GGT in patients hospitalised due to AHF.Publication Open Access Atrial conduction abnormalities in patients with psoriasis vulgaris.(2015-01-01) TASAL, A; GUVENC, TS; KUL, S; BACAKSIZ, AHMET; ERDOGAN, EZGİ BAŞAK; SONMEZ, O; SEVGILI, E; Dizman, DİDEM; ONSUN, NAHİDE; BACAKSIZ, AHMET; DİZMAN, DİDEM; ONSUN, NAHIDE; KAHRAMAN AY, NURAYBackground: Psoriasis vulgaris is one of the most common chronic inflammatory skin disorders. Patients with psoriasis are at risk of developing atrial fibrillation (AF). The electromechanical delay (EMD) is the time interval from the onset of the P wave on surface electrocardiography (ECG) to the beginning of the A wave. Prolonged atrial EMD is an independent risk factor for the development of AF. Aim: This study investigated the intra- and interatrial EMD in patients with psoriasis. Methods: This study included 85 adults with psoriasis vulgaris (Group 1) and 46 age- and sex-matched healthy individuals (Group 2). ECGs were obtained from all subjects, and atrial EMD variables were calculated. Results are reported as means ± standard deviations and percentages. Continuous variables were analysed using Student’s t-test. A p-value < 0.05 was considered statistically significant. Results: Interatrial electromechanical delay (IA-EMD) and intra-left atrial electromechanical delay (ILA-EMD) were significantly longer in the psoriasis group compared with controls. A correlation analysis between psoriasis severity (PASI score) and the atrial conduction parameters revealed a significant positive correlation between PASI and IA-EMD (r = 0.261, p < 0.001). In addition, there was a positive correlation between high-sensitivity C-reactive protein (hsCRP) and IA-EMD (p = 0.022). Conclusions: The atrial conduction time was longer in patients with psoriasis vulgaris and it correlated with the severity of disease and hsCRP. Since the association between delayed conduction and AF is known, the measurement of intra-atrial conduction times could be a practical tool to estimate the AF risk in these patients.