Person: BACAKSIZ, AHMET
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Publication Open Access Ambulatory Blood Pressure Monitoring Could Unmask Hypertension in Patients with Psoriasis Vulgaris(2013-10-29) BACAKSIZ, AHMET; Erdogan, Ercan; Sonmez, Osman; Sevgili, Emrah; Tasal, Abdurrahman; ONSUN, NAHİDE; Topukcu, Bugce; Kulac, Beytullah; UYSAL, ÖMER; Goktekin, Omer; BACAKSIZ, AHMET; ONSUN, NAHIDE; UYSAL, ÖMERBackground: Psoriasis vulgaris is one of the most prevalent chronic, inflammatory skin disorders. Patients with psoriasis have excess risk of essential hypertension. Masked hypertension (MH), defined as normal office blood pressure (BP) with elevated ambulatory BP (ABPM), has been drawing attention recently due to its association with increased risk of developing sustained hypertension, cardiovascular morbidity, and mortality. The aim of this study was to investigate the prevalence of MH in psoriatic patients. Material and Methods: On hundred and ten middle-aged, normotensive, non-obese patients with psoriasis vulgaris and 110 age- and sex-matched normotensive controls were included in the study. ABPM was performed in all participants over a 24-h period. The clinical severity of the disease was determined according to current indexes. Results: The prevalence of MH among subjects with psoriasis vulgaris was 31.8% and increased compared to control subjects (p<0.01). Predictors of MH in patients with psoriasis vulgaris were detected as male sex, smoking, obesity-related anthropometric measures, and disease activity. Male sex, waist circumference, and diffuse psoriatic involvement were detected as independent predictors of MH. Conclusions: MH is prevalent in patients with psoriasis vulgaris. Assessment with ABPM and close follow-up for development of hypertension is reasonable.Publication Metadata only Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study(2013-12-01T00:00:00Z) Erdogan, Ercan; Akkaya, Mehmet; BACAKSIZ, AHMET; Tasal, Abdurrahman; Turfan, Murat; Kul, Seref; Sonmez, Osman; Vatankulu, Mehmet Akif; Ertas, Gokhan; Batmaz, Gonca; Ergelen, Mehmet; Uyarel, Huseyin; Goktekin, Omer; BACAKSIZ, AHMETObjective: Cardiac involvement has been increasingly recognized in patients with polycystic ovary syndrome (PCOS). Identification of the earliest asymptomatic impairment of left ventricular (LV) performance may be important in preventing progression to overt heart failure. Our aim was to investigate LV function with different echocardiographic techniques in patients with PCOS. Methods: Thirty patients with PCOS and 30 age and body mass index matched healthy subjects were enrolled to this cross-sectional observational study. All subjects underwent echocardiography for assessment of resting LV function as well as two-dimensional speckle tracking echocardiography (2D-STE) and real-time three-dimensional echocardiography (3D-Echo). Global longitudinal strain (GLS) was calculated from 3 standard apical views using 2D-STE. Student t-test, Chi-square test, Pearson's, and Spearman's correlation analysis were used for statistical analysis. Results: The early mitral inflow deceleration time (DT), isovolumetric relaxation time (IVRT) and E/Em ratio were increased in the PCOS group (p<0.05 for all). Waist-to-hip ratio, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and low-density lipoprotein (LDL) levels were higher in PCOS group (p<0.05 for all). Significant correlation was observed between DT, IVRT and insulin value, HOMA-IR (p<0.05 for all). On 3D-Echo evaluation, none of the patients in both groups had LV systolic dysfunction with comparable LV ejection fraction and LV volumes. 2D-STE showed that GLS was significantly reduced in the PCOS group compared to control group (-16.78 +/- 0.56% vs. -18.36 +/- 1.04%, p<0.001). The GLS was found to be negatively correlated with waist-to-hip ratio and LDL values (p<0.05 for all). Conclusion: These results indicate that PCOS may be related to impaired LV systolic function detected by 2D-STE. In addition, PCOS may lead to diastolic dysfunction. Reduced GLS might be an early indicator of cardiac involvement in this patient population.Publication Metadata only High SYNTAX score predicts worse in-hospital clinical outcomes in patients undergoing primary angioplasty for acute myocardial infarction(2012-12-01T00:00:00Z) Kul, Seref; Akgul, Ozgur; Uyarel, Huseyin; Ergelen, Mehmet; Kucukdagli, Okkes T.; Tasal, Abdurrahman; Erdogan, Ercan; BACAKSIZ, AHMET; Sonmez, Osman; Gul, Mehmet; Uslu, Nevzat; Goktekin, Omer; BACAKSIZ, AHMETObjective A high SYNTAX score (SXscore) is a predictor of adverse outcomes for stable and unstable coronary syndromes. We aimed to examine whether a high SXscore will determine in-hospital clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.Publication Open Access Subclinical Left Ventricular Dysfunction in Women with Polycystic Ovary Syndrome(2013-10-01T00:00:00Z) Erdogan, Ercan; Akkaya, Mehmet; BACAKSIZ, AHMET; Tasal, Abdurrahman; Kul, Seref; Sonmez, Osman; Turfan, Murat; Vatankulu, Mehmet Akif; Asoglu, Emin; Sevgili, Emrah; Ergelen, Mehmet; Uyarel, Huseyin; Goktekin, Omer; BACAKSIZ, AHMETAims Cardiac involvement has been increasingly recognized in patients with polycystic ovary syndrome (PCOS). Identification of the earliest asymptomatic impairment of left ventricular (LV) performance may be important in preventing progression to overt heart failure. Our aim was to investigate LV function with different echocardiographical techniques in patients with PCOS. Methods Thirty patients with PCOS and 30 age and body mass index matched healthy subjects were enrolled to this cross-sectional observational study. All subjects underwent echocardiography for assessment of resting LV function. Global longitudinal strain (GLS) was calculated from 3 standard apical views using two-dimensional speckle tracking echocardiography (2D-STE). Results The early mitral inflow deceleration time (DT), isovolumetric relaxation time (IVRT) and E/Em ratio was increased in the PCOS group. Waist-to-hip ratio, fasting insulin, HOMA-IR and LDL levels were higher in PCOS group. Significant correlation was observed between DT, IVRT and insulin value, HOMA-IR. On real time three-dimensional echocardiography (3D-RTE) evaluation, none of the patients in both groups had LV systolic dysfunction with comparable LVEF and LV volumes. 2D-STE showed that GLS was significantly reduced in the PCOS group compared to control group (-16.78±0.56% vs. -18.36±1.04%, p<0.001). The GLS was found to be negatively correlated with waist-to-hip ratio and LDL values. Conclusıon These results indicate that PCOS may be related to impaired LV systolic function detected by 2D-STE. In addition, PCOS may lead to diastolic dysfunction. Reduced GLS might be an early indicator of cardiac involvement in this patient population.Publication Metadata only Assessment of the left atrial volume index and plasma NT-proANP level in patients with acute ST-elevation myocardial infarction(2013-01-01T00:00:00Z) BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Kayrak, Mehmet; Telli, Hasan Huseyin; AYHAN, SELİM; Sonmez, Osman; Alp, Ayse; Buyukbas, Sadik; BACAKSIZ, AHMETOBJECTIVES: Acute ST-elevation myocardial infarction is associated with ventricular dysfunction due to ischemia-induced progressive myocardial damage. The decrease in ventricular compliance causes left atrial dilatation and stretching of the atrial myocardium, which are the main stimuli for the secretion of atrial natriuretic peptide. The aim of this study was to evaluate left atrial dimensions and atrial natriuretic peptide levels in patients early after their first acute ST-elevation myocardial infarction and assess the probable interaction between coronary lesions and these measurements.Publication Metadata only Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation(2013-01-01T00:00:00Z) Ertas, Gokhan; Sonmez, Osman; Turfan, Murat; Kul, Seref; Erdogan, Ercan; Tasal, Abdurrahman; BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Altintas, Ozge; Uyarel, Huseyin; Goktekin, Omer; BACAKSIZ, AHMETBackground: Neutrophil/lymphocyte ratio (NLR) has been associated with poor outcomes in patients with cardiovascular diseases. However, little is known about the role of NLR in patients with thromboembolic stroke due to atrial fibrillation (AF). We aimed to compare the NLR ratios between non-valvular AF patients with or without thromboembolic stroke.Publication Metadata only Red cell distribution width predicts new-onset atrial fibrillation after coronary artery bypass grafting(2013-06-01T00:00:00Z) Ertas, Gokhan; AYDIN, CEMALETTİN; Sonmez, Osman; Erdogan, Ercan; Turfan, Murat; Tasal, Abdurrahman; BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Uyarel, Huseyin; Ergelen, Mehmet; ZEYBEK, RAHMİ; Goktekin, Omer; AYDIN, CEMALETTİN; BACAKSIZ, AHMET; ZEYBEK, RAHMİIntroduction. Red cell distribution width (RDW) has been associated with poor outcomes in patients with cardiovascular diseases. However, little is known about the role of RDW in prediction of new-onset atrial fibrillation (AF) after coronary artery bypass grafting (CABG). We aimed to investigate the relation between the RDW and postoperative AF in patients undergoing CABG. Methods. A total of 132 patients undergoing nonemergency CABG were included in the study. Patients with previous atrial arrhythmia or requiring concomitant valve surgery were excluded. We retrospectively analyzed 132 consecutive patients (mean age, 60.55 +/- 9.5 years; 99 male and 33 female). The RDW level was determined preoperatively and on postoperative Day 1. Results. Preoperative RDW levels were significantly higher in patients who developed AF than in those who did not (13.9 +/- 1.4 vs. 13.3 +/- 1.2, p = 0.03). There was not any correlation between postoperative RDW levels and AF. Using a cutpoint of 13.45, the preoperative level correlated with the incidence of AF with a sensitivity of 61% and specificity of 60%. Conclusion. Preoperative RDW level predicts new-onset AF after CABG in patients without histories of AF.Publication Metadata only Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure(2014-01-01T00:00:00Z) Turfan, Murat; Tasal, Abdurrahman; Erdogan, Ercan; Vatankulu, Mehmet Akif; Jafarov, Parviz; Sonmez, Osman; Ertas, Gokhan; BACAKSIZ, AHMET; Ergelen, Mehmet; Goktekin, Omer; BACAKSIZ, AHMETBackground: Acute heart failure (AHF) is a major cause of hospitalisation, morbidity and mortality worldwide. Gamma-glutamyl transferase (GGT) is an enzyme responsible for the extracellular catabolism of antioxidant glutathione and a potential risk indicator of cardiac mortality. Limited data exists on the prognostic value of circulating levels of GGT in patients hospitalised due to AHF.Publication Open Access Short Term Effect of Percutaneous Recanalization of Chronic Total Occlusions on QT Dispersion and Heart Rate Variability Parameters(2013-10-01T00:00:00Z) Erdogan, Ercan; Akkaya, Mehmet; BACAKSIZ, AHMET; Tasal, Abdurrahman; Kul, Seref; Turfan, Murat; Sonmez, Osman; Vatankulu, Mehmet Akif; Asoglu, Emin; Sevgili, Emrah; Ergelen, Mehmet; Uyarel, Huseyin; Goktekin, Omer; BACAKSIZ, AHMETBackground: QT dispersion (QTd), which is a measure of inhomogeneity of myocardial repolarization, increases following impaired myocardial perfusion. Its prolongation may provide a suitable substrate for life-threatening ventricular arrhythmias. We investigated the changes in QTd and heart rate variability (HRV) parameters after successful coronary artery revascularization in a patient with chronic total occlusions (CTO). Material/Methods: This study included 139 successfully revascularized CTO patients (118 men, 21 women, mean age 58.3±9.6 years). QTd was measured from a 12-lead electrocardiogram and was defined as the difference between maximum and minimum QT interval. HRV analyses of all subjects were obtained. Frequency domain (LF: HF) and time domain (SDNN, pNN50, and rMSSD) parameters were analyzed. QT intervals were also corrected for heart rate using Bazett’s formula, and the corrected QT interval dispersion (QTcd) was then calculated. All measurements were made before and after percutaneous coronary intervention (PCI). Results: Both QTd and QTcd showed significant improvement following successful revascularization of CTO (55.83±14.79 to 38.87±11.69; p<0.001 and 61.02±16.28 to 42.92±13.41; p<0.001). The revascularization of LAD (n=38), Cx (n=28) and RCA (n=73) resulted in decrease in HRV indices, including SDDN, rMSSD, and pNN50, but none of the variables reached statistical significance. Conclusions: Successful revascularization of CTO may result in improvement in regional heterogeneity of myocardial repolarization, evidenced as decreased QTcd after the PCI. The revascularization in CTO lesions does not seem to have a significant impact on HRVPublication Metadata only Relation Between Gamma-glutamyl Transferase And In Hospital Mortality In Acute Heart Failure Patients(2012-11-01T00:00:00Z) Turfan, Murat; Tasal, Abdurrahman; Erdogan, Ercan; Vatankulu, Mehmet Akif; Jafarov, Parviz; Sonmez, Osman; Ertas, Gokhan; BACAKSIZ, AHMET; Ergelen, Mehmet; Goktekin, Omer; BACAKSIZ, AHMET
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