Person: BACAKSIZ, AHMET
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Publication Metadata only Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study(2013-12-01T00:00:00Z) Erdogan, Ercan; Akkaya, Mehmet; BACAKSIZ, AHMET; Tasal, Abdurrahman; Turfan, Murat; Kul, Seref; Sonmez, Osman; Vatankulu, Mehmet Akif; Ertas, Gokhan; Batmaz, Gonca; Ergelen, Mehmet; Uyarel, Huseyin; Goktekin, Omer; BACAKSIZ, AHMETObjective: Cardiac involvement has been increasingly recognized in patients with polycystic ovary syndrome (PCOS). Identification of the earliest asymptomatic impairment of left ventricular (LV) performance may be important in preventing progression to overt heart failure. Our aim was to investigate LV function with different echocardiographic techniques in patients with PCOS. Methods: Thirty patients with PCOS and 30 age and body mass index matched healthy subjects were enrolled to this cross-sectional observational study. All subjects underwent echocardiography for assessment of resting LV function as well as two-dimensional speckle tracking echocardiography (2D-STE) and real-time three-dimensional echocardiography (3D-Echo). Global longitudinal strain (GLS) was calculated from 3 standard apical views using 2D-STE. Student t-test, Chi-square test, Pearson's, and Spearman's correlation analysis were used for statistical analysis. Results: The early mitral inflow deceleration time (DT), isovolumetric relaxation time (IVRT) and E/Em ratio were increased in the PCOS group (p<0.05 for all). Waist-to-hip ratio, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and low-density lipoprotein (LDL) levels were higher in PCOS group (p<0.05 for all). Significant correlation was observed between DT, IVRT and insulin value, HOMA-IR (p<0.05 for all). On 3D-Echo evaluation, none of the patients in both groups had LV systolic dysfunction with comparable LV ejection fraction and LV volumes. 2D-STE showed that GLS was significantly reduced in the PCOS group compared to control group (-16.78 +/- 0.56% vs. -18.36 +/- 1.04%, p<0.001). The GLS was found to be negatively correlated with waist-to-hip ratio and LDL values (p<0.05 for all). Conclusion: These results indicate that PCOS may be related to impaired LV systolic function detected by 2D-STE. In addition, PCOS may lead to diastolic dysfunction. Reduced GLS might be an early indicator of cardiac involvement in this patient population.Publication Metadata only High SYNTAX score predicts worse in-hospital clinical outcomes in patients undergoing primary angioplasty for acute myocardial infarction(2012-12-01T00:00:00Z) Kul, Seref; Akgul, Ozgur; Uyarel, Huseyin; Ergelen, Mehmet; Kucukdagli, Okkes T.; Tasal, Abdurrahman; Erdogan, Ercan; BACAKSIZ, AHMET; Sonmez, Osman; Gul, Mehmet; Uslu, Nevzat; Goktekin, Omer; BACAKSIZ, AHMETObjective A high SYNTAX score (SXscore) is a predictor of adverse outcomes for stable and unstable coronary syndromes. We aimed to examine whether a high SXscore will determine in-hospital clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.Publication Metadata only Assessment of the left atrial volume index and plasma NT-proANP level in patients with acute ST-elevation myocardial infarction(2013-01-01T00:00:00Z) BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Kayrak, Mehmet; Telli, Hasan Huseyin; AYHAN, SELİM; Sonmez, Osman; Alp, Ayse; Buyukbas, Sadik; BACAKSIZ, AHMETOBJECTIVES: Acute ST-elevation myocardial infarction is associated with ventricular dysfunction due to ischemia-induced progressive myocardial damage. The decrease in ventricular compliance causes left atrial dilatation and stretching of the atrial myocardium, which are the main stimuli for the secretion of atrial natriuretic peptide. The aim of this study was to evaluate left atrial dimensions and atrial natriuretic peptide levels in patients early after their first acute ST-elevation myocardial infarction and assess the probable interaction between coronary lesions and these measurements.Publication Metadata only Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation(2013-01-01T00:00:00Z) Ertas, Gokhan; Sonmez, Osman; Turfan, Murat; Kul, Seref; Erdogan, Ercan; Tasal, Abdurrahman; BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Altintas, Ozge; Uyarel, Huseyin; Goktekin, Omer; BACAKSIZ, AHMETBackground: Neutrophil/lymphocyte ratio (NLR) has been associated with poor outcomes in patients with cardiovascular diseases. However, little is known about the role of NLR in patients with thromboembolic stroke due to atrial fibrillation (AF). We aimed to compare the NLR ratios between non-valvular AF patients with or without thromboembolic stroke.Publication Metadata only Red cell distribution width predicts new-onset atrial fibrillation after coronary artery bypass grafting(2013-06-01T00:00:00Z) Ertas, Gokhan; AYDIN, CEMALETTİN; Sonmez, Osman; Erdogan, Ercan; Turfan, Murat; Tasal, Abdurrahman; BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Uyarel, Huseyin; Ergelen, Mehmet; ZEYBEK, RAHMİ; Goktekin, Omer; AYDIN, CEMALETTİN; BACAKSIZ, AHMET; ZEYBEK, RAHMİIntroduction. Red cell distribution width (RDW) has been associated with poor outcomes in patients with cardiovascular diseases. However, little is known about the role of RDW in prediction of new-onset atrial fibrillation (AF) after coronary artery bypass grafting (CABG). We aimed to investigate the relation between the RDW and postoperative AF in patients undergoing CABG. Methods. A total of 132 patients undergoing nonemergency CABG were included in the study. Patients with previous atrial arrhythmia or requiring concomitant valve surgery were excluded. We retrospectively analyzed 132 consecutive patients (mean age, 60.55 +/- 9.5 years; 99 male and 33 female). The RDW level was determined preoperatively and on postoperative Day 1. Results. Preoperative RDW levels were significantly higher in patients who developed AF than in those who did not (13.9 +/- 1.4 vs. 13.3 +/- 1.2, p = 0.03). There was not any correlation between postoperative RDW levels and AF. Using a cutpoint of 13.45, the preoperative level correlated with the incidence of AF with a sensitivity of 61% and specificity of 60%. Conclusion. Preoperative RDW level predicts new-onset AF after CABG in patients without histories of AF.Publication Metadata only Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure(2014-01-01T00:00:00Z) Turfan, Murat; Tasal, Abdurrahman; Erdogan, Ercan; Vatankulu, Mehmet Akif; Jafarov, Parviz; Sonmez, Osman; Ertas, Gokhan; BACAKSIZ, AHMET; Ergelen, Mehmet; Goktekin, Omer; BACAKSIZ, AHMETBackground: Acute heart failure (AHF) is a major cause of hospitalisation, morbidity and mortality worldwide. Gamma-glutamyl transferase (GGT) is an enzyme responsible for the extracellular catabolism of antioxidant glutathione and a potential risk indicator of cardiac mortality. Limited data exists on the prognostic value of circulating levels of GGT in patients hospitalised due to AHF.Publication Metadata only Familial sick sinus syndrome(2013-11-01T00:00:00Z) Sonmez, Osman; BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Ulucan, Hakan; Goktekin, Omer; BACAKSIZ, AHMETPublication Metadata only Does Estimated Glomerular Filtration Rate Have an Effect on Left Ventricular Function after ST-Elevation Myocardial Infarction?(2014-03-01T00:00:00Z) Sonmez, Osman; Vatankulu, Mehmet A.; Tasal, Abdurrahman; BACAKSIZ, AHMET; Ayhan, Selim; Yazici, Huseyin U.; Karakaya, Ekrem; Ozdogru, Ibrahim; AYGÜL, NAZİF; ÖZDEMİR, KURTULUŞ; Abaci, Adnan; BACAKSIZ, AHMETObjectivesLittle is known about whether estimated glomerular filtration rates (eGFR) affect left ventricular (LV) function and gain benefit with antiremodeling treatment in patients with ST-elevation myocardial infarction (STEMI). We investigated the effect of eGFR on LV function using tissue Doppler imaging (TDI) parameters. In addition, we sought to evaluate the antiremodeling effect of standard treatment at follow-up in patients with renal insufficiency (RI) after STEMI.Publication Metadata only The Relationship between Coronary Sinus and Impaired Right Ventricular Myocardial Performance Index in Mitral Stenosis(2013-09-01T00:00:00Z) Vatankulu, Mehmet Akif; KOÇ, FATİH; Gul, Enes Elvin; BACAKSIZ, AHMET; Sonmez, Osman; DEMİR, KENAN; Alihanoglu, Yusuf; Ari, Hatem; Ayhan, Selim; Tokac, Mehmet; BACAKSIZ, AHMETObjectives: We aimed to investigate whether coronary sinus (CS) dilatation develops in patients with mitral stenosis (MS) and to demonstrate its relationship with the global myocardial performance of the right ventricle (RV). Methods: We enrolled 34 patients with MS who underwent echocardiography after exhibiting typical symptoms (31 female; mean age 41 +/- 12 years) and 20 age-and sex-matched controls without MS who underwent echocardiography (16 female; mean age 38 +/- 13 years). The RV myocardial performance index (MPI) was detected using tissue Doppler echocardiography (TDE), and maximum CS diameter was measured from the posterior atrioventricular groove in the apical fourchamber view during the ventricular systole. Results: The RV MPI was significantly higher in the MS group compared to the control group (0.60 +/- 0.11 vs. 0.41 +/- 0.08, P < 0.001). Moreover, the maximum CS dimension was higher in the MS group compared to the control group (8.5 +/- 1.1 mm vs. 6.5 +/- 1.4 mm, P < 0.001). The maximum CS dilatation was positively correlated with the RV MPI (r = 0.691; P < 0.001). Conclusion: The RV MPI, which represents both systolic and diastolic functions, is increased in patients with MS and correlates with CS dilatation.Publication Metadata only Effect of estimated glomerular filtration rate on periprocedural myocardial infarction in patients undergoing elective percutaneous coronary intervention(2013-01-01T00:00:00Z) Vatankulu, Mehmet Akif; Murat, Sani Namik; Demircelik, Bora; Turfan, Murat; Sonmez, Osman; Duran, Mustafa; BACAKSIZ, AHMET; Ornek, Ender; Tasal, Abdurrahman; Goktekin, Omer; BACAKSIZ, AHMETBackgrounds: Little is known about the effect of the estimated glomerular filtration rate (eGFR) on the periprocedural myocardial infarction (PMI). The aim of this study was to determine an eGFR value that is related with PMI development in patients with stable angina undergoing elective percutaneous coronary intervention (PCI). Method: A retrospective analysis was conducted of 257 consecutive PCI patients with stable angina pectoris. The patients were divided into three groups according to eGFR: Group 1: eGFR490 mL/min/1.73 m(2), Group 2: eGFR = 60-89 mL/min/1.73 m(2), and Group 3: eGFR = 30-59 mL/min/1.73 m(2). Cardiac biomarkers were measured before, at 8, and at 24 h after the procedure. Results: Periprocedural myocardial infarction occurred in 19% of the study patients. The frequency of PMI was 13.8% in group 1, 15.2% in group 2, and 35% in group 3 (p = 0.002). There was an inverse relationship with increasing cardiac biomarkers and decreasing eGFR values. Multiple regression analysis showed that an eGFR value between 30 and 59 mL/min/1.73 m(2) was an independent variable that significantly affected PMI development after PCI. Conclusions: An estimated glomerular filtration rate between 30 and 59 mL/min/1.73 m(2) is a predictor of developing PMI after elective PCI in patients with stable angina pectoris.