Person: BACAKSIZ, AHMET
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Publication Open Access Ambulatory Blood Pressure Monitoring Could Unmask Hypertension in Patients with Psoriasis Vulgaris(2013-10-29) BACAKSIZ, AHMET; Erdogan, Ercan; Sonmez, Osman; Sevgili, Emrah; Tasal, Abdurrahman; ONSUN, NAHİDE; Topukcu, Bugce; Kulac, Beytullah; UYSAL, ÖMER; Goktekin, Omer; BACAKSIZ, AHMET; ONSUN, NAHIDE; UYSAL, ÖMERBackground: Psoriasis vulgaris is one of the most prevalent chronic, inflammatory skin disorders. Patients with psoriasis have excess risk of essential hypertension. Masked hypertension (MH), defined as normal office blood pressure (BP) with elevated ambulatory BP (ABPM), has been drawing attention recently due to its association with increased risk of developing sustained hypertension, cardiovascular morbidity, and mortality. The aim of this study was to investigate the prevalence of MH in psoriatic patients. Material and Methods: On hundred and ten middle-aged, normotensive, non-obese patients with psoriasis vulgaris and 110 age- and sex-matched normotensive controls were included in the study. ABPM was performed in all participants over a 24-h period. The clinical severity of the disease was determined according to current indexes. Results: The prevalence of MH among subjects with psoriasis vulgaris was 31.8% and increased compared to control subjects (p<0.01). Predictors of MH in patients with psoriasis vulgaris were detected as male sex, smoking, obesity-related anthropometric measures, and disease activity. Male sex, waist circumference, and diffuse psoriatic involvement were detected as independent predictors of MH. Conclusions: MH is prevalent in patients with psoriasis vulgaris. Assessment with ABPM and close follow-up for development of hypertension is reasonable.Publication Metadata only Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study(2013-12-01T00:00:00Z) Erdogan, Ercan; Akkaya, Mehmet; BACAKSIZ, AHMET; Tasal, Abdurrahman; Turfan, Murat; Kul, Seref; Sonmez, Osman; Vatankulu, Mehmet Akif; Ertas, Gokhan; Batmaz, Gonca; Ergelen, Mehmet; Uyarel, Huseyin; Goktekin, Omer; BACAKSIZ, AHMETObjective: Cardiac involvement has been increasingly recognized in patients with polycystic ovary syndrome (PCOS). Identification of the earliest asymptomatic impairment of left ventricular (LV) performance may be important in preventing progression to overt heart failure. Our aim was to investigate LV function with different echocardiographic techniques in patients with PCOS. Methods: Thirty patients with PCOS and 30 age and body mass index matched healthy subjects were enrolled to this cross-sectional observational study. All subjects underwent echocardiography for assessment of resting LV function as well as two-dimensional speckle tracking echocardiography (2D-STE) and real-time three-dimensional echocardiography (3D-Echo). Global longitudinal strain (GLS) was calculated from 3 standard apical views using 2D-STE. Student t-test, Chi-square test, Pearson's, and Spearman's correlation analysis were used for statistical analysis. Results: The early mitral inflow deceleration time (DT), isovolumetric relaxation time (IVRT) and E/Em ratio were increased in the PCOS group (p<0.05 for all). Waist-to-hip ratio, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and low-density lipoprotein (LDL) levels were higher in PCOS group (p<0.05 for all). Significant correlation was observed between DT, IVRT and insulin value, HOMA-IR (p<0.05 for all). On 3D-Echo evaluation, none of the patients in both groups had LV systolic dysfunction with comparable LV ejection fraction and LV volumes. 2D-STE showed that GLS was significantly reduced in the PCOS group compared to control group (-16.78 +/- 0.56% vs. -18.36 +/- 1.04%, p<0.001). The GLS was found to be negatively correlated with waist-to-hip ratio and LDL values (p<0.05 for all). Conclusion: These results indicate that PCOS may be related to impaired LV systolic function detected by 2D-STE. In addition, PCOS may lead to diastolic dysfunction. Reduced GLS might be an early indicator of cardiac involvement in this patient population.Publication Metadata only Bulky calcification on the left coronary cuspis causing to critical stenosis of LMCA ostium after a succesful TAVI procedure(2017-10-08T00:00:00Z) BAKSHALİYEV, NİJAD; NASİFOV, MAHARRAM; ENHOŞ, ASİM; ÖZDEN TOK, ÖZGE; KARAÇÖP, ERDEM; ULUGANYAN, MAHMUT; HUYUT, MUSTAFA AHMET; BACAKSIZ, AHMET; ÇELİKKALE, İLKE; AKDEMİR, BARIŞ; GÖKTEKİN, ÖMER; ENHOŞ, ASIM; KARAÇÖP, ERDEM; ULUGANYAN, MAHMUT; BACAKSIZ, AHMET; ÇELİKKALE, İLKEPublication Metadata only High SYNTAX score predicts worse in-hospital clinical outcomes in patients undergoing primary angioplasty for acute myocardial infarction(2012-12-01T00:00:00Z) Kul, Seref; Akgul, Ozgur; Uyarel, Huseyin; Ergelen, Mehmet; Kucukdagli, Okkes T.; Tasal, Abdurrahman; Erdogan, Ercan; BACAKSIZ, AHMET; Sonmez, Osman; Gul, Mehmet; Uslu, Nevzat; Goktekin, Omer; BACAKSIZ, AHMETObjective A high SYNTAX score (SXscore) is a predictor of adverse outcomes for stable and unstable coronary syndromes. We aimed to examine whether a high SXscore will determine in-hospital clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.Publication Metadata only Dirençli Hipertansiyonlu Hastalarda H. Pylori Sıklığı Ve H. Pylori Eradikasyonun Yüksek Kan Basıncı Üzerine Etkisi.(2017-10-14T00:00:00Z) Karatoprak, Cumali; Hamdard, Jamshid; Bacaksız, Ahmet; KARATOPRAK, CUMALİ; BACAKSIZ, AHMETAims: Helicbacter pylorinin (H. pylori) ekstraintestinal olarak birçok patolojiye neden olduğu bilinmektedir. H. pylori eradikasyonunun primer hipertansiyon üzerinde pozitif etkileri olduğunu gösteren çalışmalar mevcuttur. Bu çalışmada biri diüretik olmak üzere 3 antihipertansif ilaç kullanımına rağmen sistolik kan basıncının >140 mm-Hg ve diyastolik kan basıncının >90 mm-Hg olan dirençli hipertansif hastalarda H. pylori sıklığı ve eradikasyonun kan basıncı kontrolü üzerine etkisi araştırılmıştır.Materials and Methods: Bu çalışma prospektif gözlemsel bir çalışmadır. Hastalardan gaitada H.pylori antijeni bakılan ve dirençli hipertansiyonu olan hastalar toplandı. Bütün hastaların ambulatuvar kan basınç monitörizasyonu ile 24 saatlik kan basınçları ölçüldü ve ortalama kan basıncı sistolik 140 mmhg ve/veya diastolik 90 mm-Hg’nın üzerinde olan hastalar çalışmaya alındı. Çalışmaya uygun bulunan hastalar H.pylori pozitif olanlar bir grup negatif olanlar diğer grup olmak üzere ikiye ayrıldı. H. pylori antijeni negatif olan hastalarda tedaviye uyum, tuzsuz beslenme ve kilo vermenin önemi anlatılarak 6 hafta sonra kontrole çağrıldı ve 24 saatlik kan basıncı monitorizasyonu tekrar yapıldı. H. pylori antijeni pozitif olan hastalara 14 günlük standart (lansoprozol, amoksisilin ve klaritromisin) H. pylori eradikasyon tedavisi verildi. Eradikasyon tedavisi bittikten 4 hafta sonraki kontrollerinde dışkıda H. pylori antijeni negatif olanlarda eradikasyon başarılı kabul edildi. Dirençli esansiyel hipertansiyonlu hastalarda 6 haftalık aralarla elde edilen sistolik ve diyastolik kan basınçları karşılaştırıldı.Results: Çalışmaya 12 H. pylori (+) 37 H. pylori (-) olmak üzere toplam 49 hasta katılmıştır.Bu çalışmada H. pylori sıklığı %24.5 bulunmuştur. H.pylori (+) hastalar tedavi edildiğinde hem sistolik (26.7 mm-Hg) hemde diastolik (9 mm-Hg) kan basıncında anlamlı düşüşler gözlenmiştir (P=0.002, P=0.011 respectively). Diğer taraftan H.pylori (-) olanlarda tedavi uyumunun arttırılmasına yönelik önerilere rağmen hem sistolik (-0.5 mm-Hg) hem de diastolik (0.3 mm-Hg) kan basıncında anlamlı bir değişiklik olmamıştır (P=0.52, P=0.73, sırasıyla). Conclusion: Bu sonuçlar direçli hipertansiyonu olan hastalarda H. pylori aranması gerektiğini düşündürmektedir. Ve eğer H. pylori pozitif saptanırsa eradikasyon tedavisinin arterial kan basıncı kontrolunu sağlamada yardımcı olabileceğini düşündürmektedir.Publication Metadata only Comparison of single-dose and repeated levosimendan infusion in patients with acute exacerbation of advanced heart failure(2014-02-01T00:00:00Z) Tasal, Abdurrahman; DEMİR, MESUT; KANADAŞI, MEHMET; BACAKSIZ, AHMET; Vatankulu, Mehmet Akif; Sahin, Durmus Yildiray; Eker, Rabia Akilli; BOZKURT, ABDİ; Acarturk, Esmeray; BACAKSIZ, AHMETBackground: Levosimendan (LS) is a novel inodilator that improves cardiac performance, central hemodynamics, and symptoms of patients with decompensated chronic heart failure. The aim of this study was to compare the effects of single and repeated LS infusion on left ventricular performance, biomarkers, and neurohormonal activation in patients with acute heart failure.Publication Open Access Valve sparing surgery in an adult patient with dextrocardia and annuloaortic ectasia(2016-01-01) Zeybek, RAHMİ; Bacaksiz, AHMET; Sharifov, RASUL; SEVGILI, Emrah; Ay, YASİN; ZEYBEK, RAHMİ; BACAKSIZ, AHMET; SHARIFOV, RASUL; AY, YASİNWe report the case of a patient with situs inversus totalis, annuloaortic ectasia complicated by aortic insufficiency and mitral regurgitation which induced congestive heart failure. Both valvular lesions were repaired physiologically using aortic root sparing Yacoub 'remodeling' technique and mitral ring annuloplasty. Valve sparing techniques can be used effectively even in patients with complicated clinical scenarios (like dextrocardia and annuloaortic ectasia) to avoid the potential risks related to prosthetic valve implantation and lifelong anticoagulation therapy.Publication Metadata only The evaluation of brain natriuretic peptide changes and difficult airway predictors during perioperative period of pregnancy(2016-02-01) Basaranoglu, GÖKÇEN; UMUTOGLU, T.; BAKAN, M.; ESEN, ASIM; ATES, SEDA; BACAKSIZ, AHMET; SALIHOGLU, Z.; BAŞARANOĞLU, GÖKÇEN; ESEN, ASIM; ATEŞ, SEDA; BACAKSIZ, AHMETAim Airway changes, difficult ventilation, and intubation are the leading causes of morbidity and mortality in pregnancy, but no prospective study has evaluated the relationship between airway changes and brain natriuretic peptide (BNP) before and after cesarean section operations. The purpose of this study was to evaluate the relationship between BNP and airway changes in women undergoing delivery and during the postoperative period.Publication Open Access The effect of the SIRT1 2827 A > G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease(2015-02-01) IZMIRLI, Muzeyyen; GOKTEKIN, Omer; Bacaksiz, AHMET; Uysal, Omer; Kilic, Ulkan; BACAKSIZ, AHMET; UYSAL, ÖMERObjective: Cardiovascular disease (CVD) is the leading cause of death in Europe. One of the candidate molecule affecting epigenetic mechanisms of CVD is the SIRT1, a subclass of sirtuins, is located on the long arm of chromosome 10 (10q21.3). Particularly, the relation between 2827 A>G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet. One of the activator of SIRT1, resveratrol, is also known as a cardioprotective molecule. On the other hand, the parameters including exercise, occupation and age affect CVD. The aim of the present study was to investigate the effect of the rs144124002 (2827 A>G) single nucleotide polymorphisms (SNP) of SIRT1 and exercise-occupation-age parameters on CVD. Methods: SNP of SIRT1 were analyzed using DNA isolation, the polymerase chain reaction (PCR) and restriction fragment length polymorphism. To do so, large cohorts of CVD patients (n=293) and healthy controls (n=117) who directed Cardiology Department of Bezmialem Vakıf University, Bezmialem Vakıf University Hospital were used. Results: In this study, when we assessed CVD and control groups about 2827 A>G polymorphism, all individuals were determined as homozygous genotype. We found a positive effect between the modifications of resveratrol, exercise, age and occupation and CVD (OR=0.17; CI 95%, 0.1-0.2; p≤0.001). Conclusion: This is the first study demonstrating the correlation between the SIRT1 rs144124002 polymorphism and CVD in Turkish population. (Anatolian J Cardiol 2015; 15: 103-6) Key words: SIRT1, resveratrol, epigenetic, polymorphism, cardiovascular diseasePublication Open Access Subclinical Left Ventricular Dysfunction in Women with Polycystic Ovary Syndrome(2013-10-01T00:00:00Z) Erdogan, Ercan; Akkaya, Mehmet; BACAKSIZ, AHMET; Tasal, Abdurrahman; Kul, Seref; Sonmez, Osman; Turfan, Murat; Vatankulu, Mehmet Akif; Asoglu, Emin; Sevgili, Emrah; Ergelen, Mehmet; Uyarel, Huseyin; Goktekin, Omer; BACAKSIZ, AHMETAims Cardiac involvement has been increasingly recognized in patients with polycystic ovary syndrome (PCOS). Identification of the earliest asymptomatic impairment of left ventricular (LV) performance may be important in preventing progression to overt heart failure. Our aim was to investigate LV function with different echocardiographical techniques in patients with PCOS. Methods Thirty patients with PCOS and 30 age and body mass index matched healthy subjects were enrolled to this cross-sectional observational study. All subjects underwent echocardiography for assessment of resting LV function. Global longitudinal strain (GLS) was calculated from 3 standard apical views using two-dimensional speckle tracking echocardiography (2D-STE). Results The early mitral inflow deceleration time (DT), isovolumetric relaxation time (IVRT) and E/Em ratio was increased in the PCOS group. Waist-to-hip ratio, fasting insulin, HOMA-IR and LDL levels were higher in PCOS group. Significant correlation was observed between DT, IVRT and insulin value, HOMA-IR. On real time three-dimensional echocardiography (3D-RTE) evaluation, none of the patients in both groups had LV systolic dysfunction with comparable LVEF and LV volumes. 2D-STE showed that GLS was significantly reduced in the PCOS group compared to control group (-16.78±0.56% vs. -18.36±1.04%, p<0.001). The GLS was found to be negatively correlated with waist-to-hip ratio and LDL values. Conclusıon These results indicate that PCOS may be related to impaired LV systolic function detected by 2D-STE. In addition, PCOS may lead to diastolic dysfunction. Reduced GLS might be an early indicator of cardiac involvement in this patient population.