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ÖZTANIR, MUSTAFA NAMIK

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MUSTAFA NAMIK
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    Effects of contrast material on the metabolite ratios in single-voxel MR Spectroscopy of intraaxial brain tumors
    (2012-08-01) Alkan, ALPAY; Burulday, Veysel; Oztanir, Namik; Dogan, Metin; ERBAY, MEHMET FATİH; Kocak, Ayhan; Aralasmak, AYŞE; ALKAN, ALPAY; ÖZTANIR, MUSTAFA NAMIK; ARALAŞMAK, AYŞE
    Aim: The purpose of our study was to determine whether the administration of contrast material affects the results of MR Spectroscopy (MRS) in different intraaxial brain tumors.
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    Pott’s Puffy tumor and intracranial complication developing secondary to acute frontal sinusitis: A case report Akut frontal sinüzite bağlı gelişen pott’s puffy tümör ve intrakraniyal enfeksiyon: Olgu sunumu
    (2016-01-01T00:00:00Z) BAYINDIR, TUBA; Fırat, Çiğdem; Özerk, Ali; ÖZDEMİR, ZEYNEP; Öztanır, Namık; ÖZTANIR, MUSTAFA NAMIK
    © 2016, Logos Medical Publishing. All rights reserved.Pott’s puffy tumor is a complication that can be seen after frontal sinusitis and considered as a surgical emergency. Although it is rare, given the potential for significant morbidity, a high index of suspicion for Pott’s puffy tumor is required in patients presenting with fluctuant, tender, erythematous swelling of the scalp. High clinical suspicion for the diagnosis of the disease and confirmation of the diagnosis with imaging studies are necessary. In treatment it is important to combine the medical and surgical treatment modalities to avoid intracranial complications. In this case report, a male patient with a Potts puffy tumour developed after frontal sinusitis was presented.
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    The beneficial effects of 18 beta-glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model
    (2014-08-01T00:00:00Z) ÖZTANIR, MUSTAFA NAMIK; ÇİFTÇİ, OSMAN; Cetin, Asli; DURAK, MEHMET AKİF; Basak, Nese; Akyuva, Yener; ÖZTANIR, MUSTAFA NAMIK
    This study investigated the effects of 18 beta-glycyrrhetinic acid (GA) on neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion (I/R) in C57BL/J6 mice. All subjects (n = 40) were equally divided into four groups: (1) sham-operated (SH), (2) I/R, (3) GA, and (4) GA+I/R. The SH group was used as a control. In the I/R group, the bilateral carotid arteries were clipped for 15 min, and the mice were treated with the vehicle for 10 days. In the GA group, mice were given GA (100 mg/kg) for 10 days following a median incision without carotid occlusion. In the GA+I/R group, the I/R model was applied to the mice exactly as in the I/R group, and they were then treated with the same dose of GA for 10 days. Cerebral I/R significantly induced oxidative stress via an increase in lipid peroxidaitons and a decrease in elements of the antioxidant defense systems. However, GA treatment was protective against the oxidative effects of I/R by inducing significant increases in antioxidant defense systems and a significant decrease of lipid peroxidations. Additionally, cerebral I/R increased the incidence of histopathological damage and apoptosis in brain tissue, but these neurodegenerative effects were eliminated by GA treatment. Therefore, the current study demonstrated that GA treatment effectively prevents oxidative and histological damage in the brain caused by global I/R. In this context, GA may be useful for the attenuation of the negative effects of global cerebral I/R and, in the future, it may be a viable and safe alternative treatment for ischemic stroke in humans.
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    Anesthetic approach to adult moyamoya disease: A case report Erişkin moyamoya hastasına anestetik yaklaşım: Olgu sunumu
    (2010-01-01T00:00:00Z) Said Aydoǧan, M.; YÜCEL, AYTAÇ; ÖZGÜL, ÜLKÜ; Öztürk, Erdoǧan; Konur, Hüseyin; Namik Öztanir, MUSTAFA NAMIK; Özcan Ersoy, M.; ÖZTANIR, MUSTAFA NAMIK
    Moyamoya disease is an entity, which is caused by obstruction or stenosis in the area between the internal carotid artery, and anterior and middle cerebral arteries, identified angiographically, and does not have an exactly known etiology. The most frequent symptoms of onset are hemorrhage in adults and ischemia in children. In the treatment of moyamoya disease revascularization surgery is performed in order to decrease the vascular fragility. A specialized care is required in the perioperative period since surgery is often complicated by cerebral ischemia or cerebral hemorrhage. Aim in the perioperative anesthetic management is to provide the balance between oxygen supply to and use in the brain. In this case report we aimed to discuss the anesthetic management in a 22-year-old male patient with moyamoya disease in whom a multipl burr hole surgery was performed. © Gülhane Askeri Ti{dotless}p Akademisi 2010.
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    Comparison of immunological, histological and oxidative effects of felbamate and levetiracetam in traumatic brain injury
    (2020-01-01T00:00:00Z) Bayhan, I; TURTAY, MUHAMMET GÖKHAN; ÇİFTÇİ, OSMAN; ÇETİN, AYMELEK; Basak, N.; ÖZTANIR, MUSTAFA NAMIK; OĞUZTÜRK, HAKAN; GÜRBÜZ, ŞÜKRÜ; Guven, T.; ÖZTANIR, MUSTAFA NAMIK
    OBJECTIVE: We aimed to compare immunological, histological and oxidative effects of antiepileptic agents; felbamate and levetiracetam on head trauma in rats.
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    Giant desmoid tumor in the neck Boyunda dev desmoid tümör
    (2014-09-01T00:00:00Z) TOPLU, YÜKSEL; Öztanır, Namık; Çetinkaya, Zekeriya; Koç, Aydın; KIZILAY, AHMET; ÖZTANIR, MUSTAFA NAMIK
    Desmoid tumor is a benign tumor which originates from musculoaponeurotic system, can reach greater sizes with local invasion among facial plans, and cause severe deformities, morbidity and even mortality by compression of adjacent structures. These tumors are rarely seen in the head and neck region. The treatment of advanced desmoid tumors of head and neck region is surgery and radiotherapy. In this paper, we present -to the best of our knowledge- the greatest desmoid tumor case of the head and neck region in the literature.
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    The efficacy of hesperidin for treatment of acute otitis media
    (2019-04-01T00:00:00Z) Cetinkaya, Erdem Atalay; ÇİFTÇİ, OSMAN; ALAN, SAADET; ÖZTANIR, MUSTAFA NAMIK; Basak, Nese; ÖZTANIR, MUSTAFA NAMIK
    Objectives: In this experimental study, the effect of hesperidin on the treatment of acute otitis media (AOM) was investigated in an AOM-induced rat model.
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    Neuroprotective Effects of beta-Myrcene Following Global Cerebral Ischemia/Reperfusion-Mediated Oxidative and Neuronal Damage in a C57BL/J6 Mouse
    (2014-09-01T00:00:00Z) ÇİFTÇİ, OSMAN; ÖZTANIR, MUSTAFA NAMIK; Cetin, Asli; ÖZTANIR, MUSTAFA NAMIK
    The aim of this study was to investigate the effects of beta-myrcene (MYR) on oxidative and histological damage in brain tissue caused by global cerebral ischemia/reperfusion (I/R) in C57BL/J6 mice. Mice (n = 40) were equally divided into four groups: (1) sham-operated (SH), (2) global cerebral I/R, (3) MYR, and (4) MYR + I/R. The SH group was used as a control and received 0.1 % carboxymethyl cellulose (CMC) as a vehicle following a medial incision without carotid occlusion. In the I/R group, the bilateral carotid arteries were clipped for 15 min, and treated with the vehicle intraperitoneally (i.p.) for 10 days. In the MYR group, mice were given 200 mg/kg MYR dissolved in 0.1 % CMC for 10 days following a medial incision without carotid occlusion. In the MYR + I/R group, the I/R procedure was performed exactly as in the I/R group, and they were then treated with the same dose of MYR for 10 days. Cerebral I/R induced oxidative stress via an increase in thiobarbituric acid reactive substances (TBARS) formation and a decrease in the antioxidant defense systems, including glutathione (GSH), catalase, glutathione peroxidase (GPx) and superoxide dismutase (SOD). However, MYR treatment protected against the oxidative effects of I/R by inducing significant increases in GSH, GPx, and SOD and a significant decrease in the formation of TBARS. Additionally, cerebral I/R increased the incidence of histopathological damage and apoptosis in brain tissue, but these neurodegenerative effects were eliminated by MYR treatment. This study has demonstrated that MYR effectively attenuates oxidative and histological damage in the brain caused by global I/R. The beneficial effects of MYR probably contribute to its strong antioxidant and radical scavenging properties. In conclusion, MYR may be useful for the attenuation of the negative effects of global cerebral I/R and, in the future, may be a viable and safe alternative treatment for ischemic stroke in humans.
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    Red and White Thrombus Characteristics in Patients Undergoing Carotid Endarterectomy
    (2021-02-01T00:00:00Z) Tosun, Hatice; Kamışlı, Suat; Tecellioğlu, Mehmet; Alan, Saadet; Tecellioğlu, Fahriye Seçil; ÖZTANIR, MUSTAFA NAMIK; Kablan, Yüksel; ÖZTANIR, MUSTAFA NAMIK
    © 2020 Elsevier Inc.Objective: The study aimed to compare the characteristics of red and white thrombi in patients undergoing carotid endarterectomy. Material and Methods: The study was conducted in 81 patients with ischemic stroke who underwent carotid endarterectomy for carotid artery stenosis. Carotid plaques were graded by two pathologists. Thrombus materials were divided into two groups: white and red. The parameters of assessment were plaque rupture, lipid core, fibrous cap thickness, inflammation, intraplaque hemorrhage, calcification, necrotic core, and neovascularization. Normally distributed data were evaluated using Mann–Whitney U and Chi-squared tests. Results: The ratio of white and red thrombus was 19.8% and 80.2%, respectively. Lipid core, plaque rupture, necrotic core, neovascularization, intraplaque hemorrhage, obstruction, and inflammation were observed more in red thrombus, which were statistically significant. Calcification and fibrous cap thickness were not statistically significant in the two groups. Moreover, intimal smooth muscle cells were present in all thrombus types. Conclusion: In our study, we found that red thrombi had more unstable characteristics than white thrombi. Thus, the risk for ischemic cerebrovascular events is more in red thrombi. However, this finding cannot be generalized due to the small number of patients in this study. Therefore, studies involving more patients are needed.
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    The Evaluation of Vertebrobasilar Artery System in Neuro-Behcet and Behcet Disease using Magnetic Resonance Angiography
    (2014-07-01T00:00:00Z) KÖSE YUCA, EVREN; KAMIŞLI, SUAT; Dogan, Metin; Tasolar, Sevgi; KAHRAMAN, AYŞEGÜL; ÖZTANIR, MUSTAFA NAMIK; ŞENER, SERPİL; ÖZTANIR, MUSTAFA NAMIK
    The aim of this study is the evaluation of the vertebrobasilar artery system in patients with Behcet-s and Neuro-Behcet-s disease. For this aim; 20 adults with clinically diagnosed Behcet-s disease, 20 adults with Neuro-Behcet-s disease, and 19 age-and gender-matched controls were examined by magnetic resonance angiography (MRA). During MRA, diameters of left vertebral artery (LVA), right vertebral artery (RVA), basilar artery (BA), and proximal segment (P1) of posterior cerebral artery between origin and junction with the posterior communicating artery were measured. In all groups, LVA was dominant than RVA (P < 0.05). The diameters of BA and right P1 of Neuro-Behcet-s disease were larger than the other groups (P < 0.05). In addition, the diameters of left P1 of Neuro-Behcet-s disease were larger but not statistically significant. There is no difference between the groups in terms of gender. Behcet-s disease can affect vascular structures; therefore vertebrobasilar artery system should be examined in patients with Behcet-s and Neuro-Behcet-s disease. (C) 2014 Wiley Periodicals, Inc.