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TUNCABOYLU, DENIZ CEYLAN

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DENIZ CEYLAN
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TUNCABOYLU
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2017 - 20183
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Type: Article × Author: Tuncaboylu, DENİZ CEYLAN ×

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    Microgels from microfluidic templating and photoinduced crosslinking of cinnamylidene acetic acid modified precursors
    (2017-03-01) Tuncaboylu, DENİZ CEYLAN; WISCHKE, C.; STOERMANN, F.; LENDLEIN, A.; TUNCABOYLU, DENIZ CEYLAN
    So far, a number of approaches to synthesize microgel networks have been followed, while only in few cases a detailed control of the network architecture has been possible. Here, the photoinduced [2 + 2] cycloaddition reaction of cinnamylidene acetic acid (CAA) moieties coupled to four-arm star shaped oligo (ethylene glycol) (OEG) precursors was explored for the creation of microgels with defined polymer network structures. Based on a rational solvent selection and precursor dispersion in glass-capillary microfluidics, microgels could be successfully prepared by the proposed synthesis approach. Model reactions confirmed a quantitative network formation. Therefore, compared to common radical polymerization for microgel crosslinking, CAA-dimerization may be an alternative approach particularly when well defined network structures are desired. (C) 2017 Elsevier B.V. All rights reserved.
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    A multifunctional multimaterial system for on-demand protein release
    (2018-08-28) Tuncaboylu, DENİZ CEYLAN; FRIESS, Fabian; WISCHKE, Christian; LENDLEIN, Andreas; TUNCABOYLU, DENIZ CEYLAN
    In order to provide best control of the regeneration process for each individual patient, the release of protein drugs administered during surgery may need to be timely adapted and/or delayed according to the progress of healing/regeneration. This study aims to establish a multifunctional implant system for a local on-demand release, which is applicable for various types of proteins. It was hypothesized that a tubular multimaterial container kit, which hosts the protein of interest as a solution or gel formulation, would enable on-demand release if equipped with the capacity of diameter reduction upon external stimulation. Using devices from poly(epsilon-caprolactone) networks, it could be demonstrated that a shape-memory effect activated by heat or NIR light enabled on-demand tube shrinkage. The decrease of diameter of these shape-memory tubes (SMT) allowed expelling the payload as demonstrated for several proteins including SDF-1 alpha, a therapeutically relevant chemotactic protein, to achieve e.g. continuous release with a triggered add-on dosing (open tube) or an on-demand onset of bolus or sustained release (sealed tube). Considering the clinical relevance of protein factors in (stem) cell attraction to lesions and the progress in monitoring biomarkers in body fluids, such on-demand release systems may be further explored e.g. in heart, nerve, or bone regeneration in the future.
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    Photo-crosslinked mechanically strong PCL4-PDMAEM hydrogels
    (2018-05-01) Tuncaboylu, DENİZ CEYLAN; TUNCABOYLU, DENIZ CEYLAN
    In this study, a series of thermo-responsive hydrogels based on N-N-dimethylaminoethyl methacrylate (DMAEM) and methacrylate functionalized poly(caprolactone) (PCL4-IEMA) were prepared by bulk photo-polymerization method. Poly(caprolactone) (PCL) was modified with 2-isocyanatoethylmethacrylate (IEMA) to form a macrocrosslinker due to its excellent biocompatibility to generate high-strength smart hydrogels with pH and temperature responsivity. The synthesized macro-crosslinker and PCL4-PDMAEM hydrogel were characterized by H-1 NMR, GPC and FT-IR analyses. Sol-gel transitions were examined by oscillatory measurements in Rheometer under UV light. Swelling kinetics as a function of time, swelling ratios at different pH values and temperatures were studied. pH responsive swelling behavior of PCL4-PDMEAM hydrogels was demonstrated with a highest swelling value at pH = 2. Temperature responsivity was also proved with a LCST around 40 degrees C between the shrunken and swollen state. Young modulus of the sample was also calculated around 0.3 MPa. The results indicated that using PCL4-IEMA as a macro-crosslinker is an effective way to obtain mechanically strong - tough hydrogels by means of dissipating the applied energy through flexible crosslink units. In addition, swelling and mechanical properties of the hydrogels could be tailored by varying the amount of the crosslinker.