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TUNCABOYLU, DENIZ CEYLAN

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DENIZ CEYLAN
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TUNCABOYLU
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    PublicationOpen Access
    Design of Biocompatible Multifunctional Hydrogels with Stearyl Methacrylate and Vinylpyrrolidone
    (2022-03-01T00:00:00Z) Kilic, Husna; TUNCABOYLU, Deniz Ceylan; Argun, Aslihan; ÖZTÜRK CİVELEK, DİLEK; TUNCABOYLU, DENIZ CEYLAN; ÖZTÜRK CİVELEK, DİLEK
    Biofunctionality and biocompatibility are essential when tissue or organs are supplemented or replaced with a polymer based material. Here, we prepared stearyl methacrylate (SM) and vinylpyrrolidone (VP) based biocompatible SM-x networks with self-healing and shape memory properties. The mole ratios were gradually changed from hydrophilic to hydrophobic units between 10 and 90% to obtain gels meeting the requirements in various potential bioapplications. In addition to having a time-dependent viscoelastic character, the mechanical properties of the gels can be controlled by the amount of SM introduced into the reaction medium. Low SM content gels cannot fully return to their initial modulus values, while the gels formed with concentrations >= 60% are completely reversible due to the dynamic hydrophobic interactions, which is also effective in the self-healing behavior. Moreover, all of the networks can completely recall their permanent shape in seconds. The viability of human skin fibroblast cells, seeded on SM-x hydrogels, closely related to the water contact angle of the structures, was found to be over 82% at all x values. In the light of the findings, the wide range of properties of SM-x gel samples may show significant potential to address needs in a variety of biomedical applications.
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    PublicationOpen Access
    G-POSS connected double network starch gels for protein release
    (2023-12-01) Cosgun, Seyma Nur Kirmic; Tuncaboylu, Deniz Ceylan; Alemdar, Mahinur; TUNCABOYLU, DENIZ CEYLAN
    Starch is one of the most frequently preferred natural polymers in hydrogel synthesis. Herein, we combined two strategies of associating brittle and ductile networks in a structure and incorporating inorganic particles into the polymeric gel to design mechanically enhanced nanocomposite double network (DN) starch gels. For the first time in the literature, nanocomposite starch gels (s-NC) were designed by cross-linking starch chains with 8-armed glycidyl-polyhedral oligomeric silsesquioxane (g-POSS) units. Fourier Transform Infrared Spectroscopy and Energy Dispersive X-Ray Spectroscopy analyses have proven that g-POSS is included in the gel structure and is homogeneously distributed throughout the network. More stable d-NC-DMA and d-NC-VP gels were obtained by incorporating N,N-dimethylacrylamide (DMA), or 1-vinyl-2-pyrrolidinone (VP) units, respectively, into g-POSS-linked starch gels, and the reaction kinetics were followed in situ. In SEM images, it was observed that d-NC-DMA had smaller pores and thicker pore walls compared to s-NC and d-NC-VP starch gels, and its mechanical strength was shown to be much superior by rheological tests, compression, and tensile analyses. In addition to increasing the mechanical strength of the gels, the potential of starch in protein release applications using amylase sensitivity has been demonstrated in vitro experiments using the model protein BSA.