Person: YÜKSEL MAYDA, PELİN
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Publication Metadata only Confirmatory test results in anti-HIV-positive patients: Evaluation of five-year data Anti-HIV-pozitif hastalarda doǧrulama testi sonuçlari: Beş yillik verilerin i̇rdelenmesi(2010-08-01T00:00:00Z) Yüksel, PELİN; Ziver, Tevhide; Izmirli, Sena; Aslan, Mustafa; Saribaş, Suat; Güngördü, Zeynep; Yakar, Hakan; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİNPublication Metadata only Can the nucleic acid amplification test (NAT) be an alternative to the serologic tests? A prospective study, the results of 18,200 blood donors from the Turkish Red Crescent(2010-12-01T00:00:00Z) Kosan, Erdogan; Kocazeybek, Bekir; Altunay, Husnu; Aymelek, Meryem; Alan, Esra; Saribas, Suat; Aslan, Mustafa; Yenen, Osman Sadi; Yuksel, PELİN; Birinci, Ilhan; Kirali, Kaan; Aksoy, Armagan; YÜKSEL MAYDA, PELİNAim: Serologic tests having high sensitivity and specificity are used in order to prevent contamination with infectious agents from blood and blood products for transfusion safety. The present serologic tests have problems such as low sensitivity and weak detection capacity of infectious agents in the -window period-. We aimed to test the use of NAT (Nucleic Acid Amplification Test) in routine blood screening in the Blood Bank.Publication Metadata only Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey(2015-05-01T00:00:00Z) Caliskan, Reyhan; Tokman, Hrisi Bahar; Erzin, Yusuf; Saribas, Suat; Yuksel, Pelin; Bolek, Bora Kazim; Sevuk, Ecehan Ozge; Demirci, Mehmet; Yilmazli, Ozge; Akgul, Ozer; Kalayci, Fatma; Cakan, Huseyin; Salih, Barik; Bal, Kadir; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİNIntroduction: Antibiotic resistance is the main factor that affects the efficacy of current therapeutic regimens against Helicobacter pylori. This study aimed to determine the rates of resistance to efficacy clarithromycin, amoxicillin, tetracycline, levofloxacin and metronidazole among H. pylori strains isolated from Turkish patients with dyspepsia. Methods: H. pylori was cultured from corpus and antrum biopsies that were collected from patients with dyspeptic symptoms, and the antimicrobial susceptibility of H. pylori was determined using the E-test (clarithromycin, amoxicillin, tetracycline, metronidazole and levofloxacin) according to the EUCAST breakpoints. Point mutations in the 23S rRNA gene of clarithromycin-resistant strains were investigated using real-time PCR. Results: A total of 98 H. pylori strains were isolated, all of which were susceptible to amoxicillin and tetracycline. Of these strains, 36.7% (36/98) were resistant to clarithromycin, 35.5% (34/98) were resistant to metronidazole, and 29.5% (29/98) were resistant to levofloxacin. Multiple resistance was detected in 19.3% of the isolates. The A2143G and A2144G point mutations in the 23S rRNA-encoding gene were found in all 36 (100%) of the clarithromycin-resistant strains. Additionally, the levofloxacin MIC values increased to 32 mg/L in our H. pylori strains. Finally, among the clarithromycin-resistant strains, 27.2% were resistant to levofloxacin, and 45.4% were resistant to metronidazole. Conclusions: We conclude that treatment failure after clarithromycin-or levofloxacin-based triple therapy is not surprising and that metronidazole is not a reliable agent for the eradication of H. pylori infection in Turkey.Publication Metadata only The importance of transmission time in HIV infections and an epidemiological prospective follow-up study for 1year in the Marmara Region of Turkey(2012-08-01T00:00:00Z) Celik, Deniz Gozde; Yuksel, PELİN; Aslan, Mustafa; Saribas, Suat; BALTALI, Nezihe Dirik; Abdelkareem, Ali; Ziver, Tevhide; NAZLICAN, Ozcan; GENCER, Serap; CELIKKOL, Erdoĝan; BAHAR, Hrisi; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİNPublication Metadata only Entamoeba histolytica lectin antigen from stool Specimens by ELISA method: 3-Year data Dişki{dotless} örneklerinde ELISA yöntemiyle entamoeba histolytica lektin antijeninin gösterilmesi: Üç yi{dotless}lli{dotless}k veriler(2011-12-01T00:00:00Z) Yüksel, PELİN; Çelik, Deniz Gözde; Güngördü, Zeynep; Ziver, Tevhide; Izmirli, Sena; Yakar, Hakan; Saribaş, Suat; Aslan, Mustafa; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİNPublication Metadata only Problems encountered in conventional HIV 1/2 algorithms: Lack of necessity for immunoblot assays to confirm repeated ELISA reactive results(2018-06-01T00:00:00Z) Yuksel, Pelin; Saribas, Suat; Kuskucu, Mert; Mutcali, Sibel Islak; Kosan, Erdogan; Habip, Zafer; Demirci, Mehmet; Kara, Eda Salihoglu; Birinci, Ilhan; Caliskan, Reyhan; Dinc, HARİKA ÖYKÜ; Midilli, Kenan; Ziver, Tevhide; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜBackground: The use of conventional (serologically based) HIV 1/2 diagnostic algorithms has become controversial in recent years.Publication Metadata only HEPATITIS A VIRUSVACCINATION IN AUTOINFLAMMATORY DISEASES UNDER CANAKINUMAB AND TOCILIZUMAB TREATMENT(2019-06-01T00:00:00Z) Barut, Kenan; Adrovic, Amra; Sahin, Sezgin; Yildiz, Mehmet; Koker, Oya; Yalcin, Gamze; Beser, Omer Faruk; Kocazeybek, Bekir; Yuksel, PELİN; Kasapcopur, Ozgur; YÜKSEL MAYDA, PELİNPublication Open Access Diagnostic performance of the RT-qPCR method targeting 85B mRNA in the diagnosis of pulmonary Mycobacterium tuberculosis infection(2018-09-01T00:00:00Z) Demirci, Mehmet; Saribas, Suat; Ozer, Nigar; TOPRAK, Sezer; CAGLAR, Emel; ORTAKOYLU, Gonenc; Yuksel, PELİN; Ayaz, Gulsel; Tokman, Hrisi B.; Uysal, Omer; Dinc, HARİKA ÖYKÜ; ZİVER, Tevhide; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN; UYSAL, ÖMER; DİNÇ, HARİKA ÖYKÜBackground: Several nucleic acid amplification techniques (IS6110, 16S rRNA, and 85B mRNA) were developed for the rapid, direct detection of Mycobacterium tuberculosis. We aimed to assess the diagnostic performance of 85B mRNA-based RT-qPCR by comparing with the real-time PCR COBAS TagMan MTB Kit while using the BACTEC MGIT 960 method as the gold standard.Publication Metadata only The relationship of Chlamydophila pneumoniae with schizophrenia: The role of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in this relationship(2017-01-01T00:00:00Z) Kalayci, Fatma; Ozdemir, Armagan; Saribas, Suat; Yuksel, Pelin; Ergin, Sevgi; Kuskucu, Ali Mert; Poyraz, Cana Aksoy; Balcioglu, Ibrahim; Alpay, Nihat; Kurt, Aykut; Sezgin, Zeynep; Kocak, Banu Tufan; Icel, Rana Sucu; Can, Gunay; Tokman, Hrisi Bahar; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİNSeveral pathogens have been suspected of playing a role in the pathogenesis of schizophrenia. Chronic inflammation has been proposed to occur as a result of persistent infection caused by Chlamydophila pneumoniae cells that reside in brain endothelial cells for many years. It was recently hypothesized that brain-derived neurotrophic factor ( BDNF) and neurotrophin-3 (NT-3) may play prominent roles in the development of schizophrenia. NT3 and BDNF levels have been suggested to change in response to various manifestations of infection. Therefore, we aimed to elucidate the roles of BDNF and NT3 in the schizophrenia-C. pneumoniae infection relationship. RT-PCR, immunofluorescence and ELISA methods were used. Fifty patients suffering from schizophrenia and 35 healthy individuals were included as the patient group (PG) and the healthy control group (HCG), respectively. We detected persistent infection in 14 of the 50 individuals in the PG and in 1 of the 35 individuals in the HCG. A significant difference was found between the two groups (p 0.05). C. pneumoniae DNA was not detected in any group. A significant difference in NT-3 levels was observed between the groups, with very low levels in the PG (p 0.05). In conclusion, we suggest that NT-3 levels during persistent C. pneumoniaeinfection may play a role in this relationship. (C) 2016 Asociaci on Argentina de Microbiologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND licensePublication Metadata only Diagnosis of Epstein-Barr virus infection with EBV IgM/IgG and monospot test evaluation Epstein-barr virusu infeksiyonu tani{dotless}si{dotless}nda EBV IgM/IgG ve monospot testlerinin i̇rdelenmesi(2012-01-01T00:00:00Z) Sirekbasan, Serhat; Çelik, Deniz Gözde; Abdelkareem, Ali; Yüksel, PELİN; Aslan, Mustafa; Saribaş, Suat; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN
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