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YÜKSEL MAYDA, PELİN

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2015 - 20209
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Author: DİNÇ, HARİKA ÖYKÜ × Type: Article ×

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Now showing 1 - 9 of 9
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    Problems encountered in conventional HIV 1/2 algorithms: Lack of necessity for immunoblot assays to confirm repeated ELISA reactive results
    (2018-06-01T00:00:00Z) Yuksel, Pelin; Saribas, Suat; Kuskucu, Mert; Mutcali, Sibel Islak; Kosan, Erdogan; Habip, Zafer; Demirci, Mehmet; Kara, Eda Salihoglu; Birinci, Ilhan; Caliskan, Reyhan; Dinc, HARİKA ÖYKÜ; Midilli, Kenan; Ziver, Tevhide; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    Background: The use of conventional (serologically based) HIV 1/2 diagnostic algorithms has become controversial in recent years.
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    PublicationOpen Access
    Diagnostic performance of the RT-qPCR method targeting 85B mRNA in the diagnosis of pulmonary Mycobacterium tuberculosis infection
    (2018-09-01T00:00:00Z) Demirci, Mehmet; Saribas, Suat; Ozer, Nigar; TOPRAK, Sezer; CAGLAR, Emel; ORTAKOYLU, Gonenc; Yuksel, PELİN; Ayaz, Gulsel; Tokman, Hrisi B.; Uysal, Omer; Dinc, HARİKA ÖYKÜ; ZİVER, Tevhide; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN; UYSAL, ÖMER; DİNÇ, HARİKA ÖYKÜ
    Background: Several nucleic acid amplification techniques (IS6110, 16S rRNA, and 85B mRNA) were developed for the rapid, direct detection of Mycobacterium tuberculosis. We aimed to assess the diagnostic performance of 85B mRNA-based RT-qPCR by comparing with the real-time PCR COBAS TagMan MTB Kit while using the BACTEC MGIT 960 method as the gold standard.
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    Evaluation of Adenovirus-36 (Ad-36) antibody seropositivity and adipokine levels in obese children
    (2017-07-01T00:00:00Z) Kocazeybek, Bekir; Dinc, HARİKA ÖYKÜ; Ergin, Sevgi; Saribas, Suat; Ozcabi, Bahar Taskm; Cizmecigil, Utku; Altan, Eda; Atalik, Keyser; Yuksel, Pelin; Taner, Zeynep; Karakullukcu, Asiye; Sirekbasan, Serhat; Turan, Nuri; Cagatay, Penbe; Imamova, Nergiz; Evliyaoglu, Olcay; Yilmaz, Huseyin; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİN
    Adenovirus 36 (Ad-36) has recently been suggested as a possible contributor to the current obesity epidemic. The aim of this study was to investigate the prevalence of Ad-36 antibodies in obese children, as well as investigate the role of serum leptin and lipid levels in Ad-36-obesity. Seventy-one obese children and 62 non-obese children were included as the patient group (PG), including the healthy control group (HCG), respectively. Simultaneously, Ad-36 antibodies and adipokine levels were assessed with serum neutralization assays (SNA) and ELISA. Ad-36 antibody was detected in 9 patients (12.7%) and 1 patient (1.6%) in both the PG and HCG, respectively, while a significant difference was detected between groups (p < 0.05). Although serum LDL, total cholesterol, triglycerides and leptin levels were detected significantly higher, adiponectin level was detected paradoxically lower in the PG. However, a significant difference was not detected for lipids and leptin levels; adiponectin levels were found to be significantly lower in Ad-36 antibody-positive PG (p < 0.05).
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    Travel-associated infections caused by unusual serogroups of Legionella pneumophila identified using Legionella BIOCHIP slides in Turkey and Iraq
    (2016-05-01T00:00:00Z) Kocazeybek, Bekir S.; Yuksel, Pelin; Keskin, Dilek; Sheikh, Suhail; Habip, Zafer; Yavuzer, Serap Sahin; Caliskan, Reyhan; Altun, Yagiz Meric; Kuskucu, Mert; Cengiz, Mahir; Dinc, HARİKA ÖYKÜ; Karakullukcu, Asiye; Ergin, Sevgi; Saribas, Suat; Yilmaz, Nail; Tokman, Hrisi Bahar; YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    Background: Although Legionella pneumophila serogroup 1 is the common disease causing serogroup, rare serogroups can also may cause legionellosis. A 54-year-old male patient (index case) reported that he had been on a religious trip (for visiting, tomb of Ali, which is important for Shias) to Iraq with a large group (50 shia pilgrims from Kars city of Turkey) two weeks prior to admission. Due to civil war, the hotel where the patient stayed in Iraq lacked proper hygiene. A large number of people in the travel group were experiencing the same symptoms. Other five cases were 2 males (ages; 50, 45) and 3 females including the wife of the index case (ages; 50, 28, 27).
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    Serum neopterin and procalcitonin levels in relationship with pediatric burn wound infections
    (2016-03-01T00:00:00Z) Pilanci, Ozgur; Ergin, Sevgi; Sirekbasan, Serhat; Ersin, Idris; Habip, Zafer; Yuksel, Pelin; Kuvat, Nuray; Aslan, Mustafa; Dinc, Oyku; Saribas, Suat; Kocazeybek, Bekir; YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    Infection and septic complications in burn patients can be monitored by procalcitonin (PCT) and neopterin plasma values. The aim of the study was to investigate serum neopterin and PCT levels with WBC (white blood cell) and CRP (C-reactive protein) levels in patient group (PG) and healthy control group (HCG) and to investigate the relationship of these markers with burn wound infections (BWI). As the PG, 23 patients between 0-12 ages and up to 30% Total Body Surface Area (TBSA) burned and 15 HCG were included. PCT, neopterin, WBC, and CRP results on the first, the seventh, the fourteenth and the 21st day have been compared. During the follow-up period, 11 patients with BWI and 12 patients without BWI were classified as infected and non-infected patients, respectively. PCT and neopterin levels were detected higher in patients with BWI but no significant difference were present. Also, PCT and neopterin levels within the first 24 hours following the burn were detected higher in PG than HCG. CRP and WBC levels were detected high due to burn trauma. PCT and neopterin levels were increased in patients with BWI. PCT levels were increased during the pre-infectious period, while neopterin levels increased during the post-infectious period.
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    Mutations in the 23S rRNA genes of Helicobacter pylori mediate resistance to clarithromycin (A preliminary study)
    (2018-08-01T00:00:00Z) Ergin, Selma; Kocazeybek, B.; Caliskan, R.; Demiryas, S.; Dinc, O.; Gulergun, R.; Tokman, H. Bahar; Ziver, T.; Saribas, S.; Yuksel, PELİN; Kalayci, F.; Demirci, M.; Tasci, I.; Erzin, Y.; Bal, K.; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİN
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    Patterns of epiya motifs among cagA-positive Helicobacter pylori strains: A case–control study in a turkish population with eurasian geographical features
    (2015-10-01T00:00:00Z) Kocazeybek, Bekir Sami; Caliskan, Reyhan; Cetin, Sibel Erdamar; Ergin, Sevgi; Kuskucu, Mert; Kepil, Nuray; Dinc, HARİKA ÖYKÜ; Erzin, Yusuf Ziya; Saribas, Suat; Tokman, Hrisi Bahar; Kalayci, Fatma; Akgul, Ozer; Yuksel, Pelin; Karakullukcu, Asiye; Ziver, Tevhide; Sirekbasan, Serhat; Caglar, Erkan; Bal, Kadir; DİNÇ, HARİKA ÖYKÜ; YÜKSEL MAYDA, PELİN
    Geographical variation in the frequency of various gastroduodenal pathologies was shown to be related to the geographical diversity of H. pylori CagA Glu-Pro-lle-Tyr-Ala (EPIYA) patterns. We examined the EPIYA patterns of H. pylori and the association of EPIYA patterns with gastric cancer (GC) for the first time, to the best of our knowledge, in Turkey. The patient group (PG) contained 60 patients [38 GC and 22 duodenal ulcer (DU) patients]. The control group (CG) was 110 individuals [94 gastritis patients and 16 persons with a normal gastrointestinal system (NGIS)]. Specific primers were used for the detection of cagA including empty-site-positive and EPIYA-A, -B, -C, -D PCR. Bands of EPIYA-A, -B, -C were confirmed by DNA sequencing. One hundred and forty-two (83.5 %) strains [60 in the PG (38 GC, 22 DU), 82 in the CG (72 gastritis, 10 NGIS)] were positive for the cagA gene. EPIYA-C with multiple repeats was detected in 34 (23.9 %) strains, and 22 (64.7 %) were from GC patients. EPIYA-C with one repeat was detected in 89 (62.7 %) strains, and 54 (60.7 %) were from gastritis patients. EPIYT was detected in 10 strains, and EPIYA-D was not detected. The number of EPIYA-C with multiple repeats was significantly higher for the PG than for the CG (P<0.0001). In GC patients, the number of EPIYA-C with multiple repeats was significantly higher than one repeat (P<0.0001). In conclusion, our study showed that multiple EPIYA-C repeats increases the GC risk by 30.6-fold and the DU risk by 8.9-fold versus the CG. This indicates that Western-type H. pylori strains in Turkey have similar EPIYA motifs to those of neighbouring countries and Western populations.
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    Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases
    (2017-08-01) Dinc, Harika Oyku; SOHRABİ, Pari; Habip, Zafer; Saribas, Suat; Vatan, Asli; Altun, Yagiz M.; ZİVER, Tevhide; Caliskan, Reyhan; Demirci, Mehmet; Uysal, Omer; Yuksel, Pelin; Kocazeybek, Bekir; DİNÇ, HARİKA ÖYKÜ; UYSAL, ÖMER; YÜKSEL MAYDA, PELİN
    Aim: Isolated hepatitis B core antibodies (aHBc)-only pattern complicates the diagnosis of HBV infections. We evaluated neopterin and sCD14 levels in HBV infections. Methods: aHBc-only (n: 102), healthy control (healthy control group [HCG], n: 100), and chronic hepatitis (CHB) groups (n: 70) were investigated. Competitive and sandwich ELISA were used. Results: The mean neopterin levels were significantly lower in the aHBc-only group than those in the CHB group (p = 0.0001). No significant difference was found between the aHBc-only group and the HCG (p = 0.854). The mean sCD14 levels were lower in the aHBc-only group than those in the CHB group (p = 0.0001), but no significant difference was found between the aHBc-only group and HCG (p = 0.402). No significant difference was detected between aHBc-only and HCG for mean sCD14 (p = 0.402) and neopterin levels (p = 0.854). Conclusion: These two biomarkers are not useful for diagnosing the aHBc only pattern.
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    PublicationOpen Access
    History of Epidemics and COVID-19
    (2020-12-01T00:00:00Z) YÜKSEL MAYDA, PELİN; DİNÇ, HARİKA ÖYKÜ
    In archaeological excavations, it has been reported that formations resembling bacterial fossils are found among the rock layers and they belong to millions of years ago. There are those who have created the flora and preserved us by creating our flora, and those that have brought us to the end, as well as those that help us to form the microorganisms that we share with the same planet, whose existence dates back to ancient times. Although our immune system and medical facilities are trump cards against microorganisms living in the world for much longer than human beings, these are not always enough to protect us, and microorganisms are causing outbreaks that will make history. In this review, we aimed to examine the epidemic diseases experienced by human beings from past to present and their effects.