Person: GÜRSU, MELTEM
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Publication Open Access Changes in the inflammatory markers with advancing stages of diabetic nephropathy and the role of pentraxin-3.(2016-09-01) UZUN, S; OZARI, M; Gursu, MELTEM; KARADAG, S; BEHLUL, A; SARI, S; KOLDAS, M; DEMIR, S; KARAALI, Z; OZTURK, S; GÜRSU, MELTEMPublication Open Access Placement of hemodialysis catheters with a technical, functional, and anatomical viewpoint.(2012-01-01T00:00:00Z) AYDIN, Z; Gursu, MELTEM; UZUN, S; KARADAG, S; TATLI, E; SUMNU, A; OZTURK, S; Kazancioglu, RÜMEYZA; GÜRSU, MELTEM; KAZANCIOĞLU, RÜMEYZAPublication Open Access Volume status in patients on peritoneal dialysis: the role of apelin and bio-impedance spectroscopy(2012-01-01T00:00:00Z) Kazancioglu, RÜMEYZA; Gursu, MELTEM; KARADAG, S; TATLI, E; AYDIN, Z; UZUN, S; SUMNU, A; CEBECI, E; OZTURK, S; KAZANCIOĞLU, RÜMEYZA; GÜRSU, MELTEMOne of the main factors determining the survival of peritoneal dialysis (PD) patients is volume status. We aimed to investigate hydration status of PD patients by bio-impedance spectroscopy (BIS) and echocardiography and to study the relation of them with apelin, which has effects related with volume status like vasodilation, positive inotropism, and inhibition of ADH release and RAS antagonism. Chronic PD patients without active cardiac disease or clinically prominent hypervolemia were included. Besides the demographic, clinical, and laboratory data, BIS and echocardiographic findings together with apelin levels were recorded. The study included 21 patients. Of them, eight patients were euvolemic, one patient was hypovolemic, and others have some degree of overhydration (1.1-6.8 L) with BIS, although all were euvolemic clinically. Mean apelin level was 1.49 +/- 0.49 ng/mL. Apelin level was positively correlated with ejection fraction and negatively with total body water (TBW), intracellular and extracellular water, lean tissue mass, and left atrium diameter. On linear regression model, TBW was the major determinant of apelin. Although apelin is expected to increase in hypervolemic patients, the negative correlation with body water in this study may be related with yet unknown role of apelin in dialyzed patients. They may have important roles in volume status in future.Publication Open Access A Case of Primary Hypoparathyroidism Presenting with Acute Kidney Injury Secondary to Rhabdomyolysis.(2016-01-01) SUMNU, A; AYDIN, Z; GURSU, MELTEM; UZUN, S; KARADAG, S; CEBECI, E; OZTURK, S; Kazancioglu, RÜMEYZA; GÜRSU, MELTEM; KAZANCIOĞLU, RÜMEYZASymmetric calcification of the basal ganglia identified radiographically occurs in a variety of familial and nonfamilial conditions. Primary Familial Brain Calcifications (PFBC), which were known by many names previously, including Fahr disease and striopallidodentate calcinosis, are a genetic disease characterized by various mutations in four separate genes and autosomal dominant inheritance [1–4]. PFBC may present with various psychiatric and neurological symptoms [5]. On the other hand, many secondary causes, either infectious, toxic, or metabolic, have been described to cause symmetrical basal ganglion calcifications and so are in the differential diagnosis of PFBC [6]. Parathyroid diseases such as hypoparathyroidism, pseudohypoparathyroidism, and pseudo-pseudohypoparathyroidism are in the forefront among the metabolic causes. Idiopathic or postsurgical hypoparathyroidism is the most common cause of symmetric calcification of the basal ganglia [7–9]. Herein, a case of primary hypoparathyroidism with severe tetany, rhabdomyolysis, and acute kidney injury (AKI) is presented.Publication Open Access Skin disorders in peritoneal dialysis patients: An underdiagnosed subject.(2016-07-06) Gursu, MELTEM; UZUN, S; TOPCUOĞLU, D; Koc, LK; Yucel, L; SUMNU, A; CEBECI, E; OZKAN, O; BEHLUL, A; Koc, L; OZTURK, S; KAZANCIOGLU, RÜMEYZA; GÜRSU, MELTEM; KAZANCIOĞLU, RÜMEYZAAIM: To examine all skin changes in peritoneal dialysis (PD) patients followed up in our unit. METHODS: Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all findings recorded. The demographic, clinical and laboratory data including measures of dialysis adequacy of patients were recorded also. Statistical Package for Social Sciences (SPSS) for Windows 16.0 standard version was used for statistical analysis. RESULTS: Among the patients followed up in our PD unit, those without exclusion criteria who gave informed consent, 38 patients were included in the study with male/female ratio and mean age of 26/12 and 50.3 ± 13.7 years, respectively. The duration of CKD was 7.86 ± 4.16 years and the mean PD duration was 47.1 ± 29.6 mo. Primary kidney disease was diabetic nephropathy in 11, nephrosclerosis in six, uropathologies in four, chronic glomerulonephritis in three, chronic pyelonephritis in three, autosomal dominant polycystic kidney disease in three patients while cause was unknown in eight patients. All patients except for one patient had at least one skin lesion. Loss of lunula, onychomycosis and tinea pedis are the most frequent skin disorders recorded in the study group. Diabetic patients had tinea pedis more frequently (P = 0.045). No relationship of skin findings was detected with primary renal diseases, comorbidities and medications that the patients were using. CONCLUSION: Skin abnormalities are common in in PD patients. The most frequent skin pathologies are onychomycosis and tinea pedis which must not be overlooked.Publication Open Access Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study.(2016-01-01) YILDIRIM, ZEYNEP BEYZA; SUMNU, A; BADEMLER, N; KILIC, ERDEM; SUMNU, G; KARADAG, S; GURSU, MELTEM; OZEL, A; BATMAZ, G; ATES, SEDA; Dane, B; OZTURK, S; YILDIRIM, ZEYNEP BEYZA; KILIÇ, ERDEM; GÜRSU, MELTEM; ATEŞ, SEDA; KILIÇOĞLU DANE, PAKİZER BANUntroduction: All findings of preeclampsia appear as the clinical consequences of diffuse endothelial dysfunction. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) was recently introduced as a TNF related cytokine in various inflammatory and noninflammatory disorders. sTWEAK was found to be related to endothelial dysfunction in patients with chronic kidney disease. In our study we aimed to compare sTWEAK levels in women with preeclampsia to corresponding levels in a healthy pregnant control group. Materials and methods: The study was undertaken with 33 patients with preeclampsia and 33 normal pregnant women. The concentration of sTWEAK in serum was calculated with an enzyme linked immunosorbent assay (ELISA) kit. Results: Serum creatinine, uric acid, LDH levels, and uPCR were significantly higher in the patient group compared to the control group. sTWEAK levels were significantly lower in preeclamptic patients (332 ± 144 pg/mL) than in control subjects (412 ± 166 pg/mL) (p = 0.04). Discussion: Our study demonstrates that sTWEAK is decreased in patients with preeclampsia compared to healthy pregnant women. There is a need for further studies to identify the role of sTWEAK in the pathogenesis of preeclampsia and to determine whether it can be regarded as a predictor of the development of preeclampsia.Publication Open Access The correlation of inflammatory markers and plasma vaspin levels in patients with diabetic nephropathy.(2016-08-01) KARADAG, S; SAKCI, E; UZUN, S; AYDIN, Z; CEBECI, E; SUMNU, A; OZKAN, O; YAMAK, M; KOLDAS, M; BEHLUL, A; Gursu, MELTEM; ATAOGLU, E; OZTURK, S; GÜRSU, MELTEM