Person: DÜNDAR, TOLGA TURAN
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Publication Metadata only The Role of Staged Cryosurgery and Three-Dimensional Computed Tomography Integrated Navigation System in the Surgical Management of Severe Involvement of Craniofacial Polyostotic Fibrous Dysplasia(2020-01-01T00:00:00Z) Dündar, Tolga Turan; YILDIZ, KEMALETTİN; DÜNDAR, TOLGA TURAN; MEHDIZADE, TURAN; GÜNEREN, ETHEMFibrous dysplasia (FD) is a developmental bone disorder caused by the hamartamatous proliferation of bone-forming cells. A 29-year-old male patient with diagnosis of FD was admitted to our clinic with the symptoms of severe craniomaxillofacial involvement of FD beginning from last year. Neurological examination revealed diplopia, horizontal nystagmus, conductive hearing loss, and partial vision loss. In his medical history, it was reported that he had undergone intramedullary nailing operation in his left femur due to a pathological fracture approximately 8 years ago in the orthopedics clinic of our institution. The patient underwent 3 consecutive surgeries by our plastic and neurosurgical team. The patient was followed-up in the neuro-intensive care unit between the surgical sessions and 1 week after the last operation. Afterwards, he was transferred to the neurosurgical department. No postoperative complication was detected. The preoperative signs were recovered. During his 6th month follow-up control-visit, all his preoperative symptoms were improved. In addition, the patient was satisfied with his postoperative cosmetic improvement. In conclusion, virtual surgical planning and intraoperative surgical navigation systems can make the challenging cases possible to operate with increasingPublication Metadata only Anevrizmatik subaraknoid kanama sonrası prognostik faktör olarak platelet volüm indeksinin değerlendirilmesi(2019-09-01) Dündar, Tolga Turan; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; YURTSEVER, İSMAİLPublication Open Access A Rare Cause of Headache in the Emergency Department: Intraventricular Epidermoid Cyst Rupture With Hydrocephalus.(2016-07-01) YIGIT, M; Seyithanoglu, MEHMET HAKAN; DUNDAR, TOLGA TURAN; SOGUT, O; YIGIT, E; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURANLateral intraventricular tumors are not frequently observed. Since these tumors grow linearly rather than exponentially, they grow gradually and thus do not cause mass effects and hydrocephalus. This study is the case report of a rare great volume left intraventricular epidermoid cyst rupture. The tumor was found to be associated with mass effect on neighboring structures and hydrocephalus.Publication Metadata only COMPARISON BETWEEN THE PRE- AND POSTOPERATIVE RADIOLOGICAL FINDINGS AND CLINICAL OUTCOMES EVALUATION OF THE PATIENTS WHO UNDERWENT SURGERY FOR LUMBAR SPONDYLOLISTHESIS(2018-04-01T00:00:00Z) Papaker, Meliha Gundağ; EMEL, ERHAN; Abdallah, Anas; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURAN; Kitiş, Serkan; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURANPublication Metadata only Beyin Tümörü Kök Hücresi(2018-09-01T00:00:00Z) DÜNDAR, TOLGA TURAN; Kitiş, Serkan; Papaker, Meliha Gundağ; Abdallah, Anas; Ozek, Erdinc; SEYİTHANOĞLU, MEHMET HAKAN; ÇETİN, GÜVEN; DÜNDAR, TOLGA TURAN; SEYİTHANOĞLU, MEHMET HAKAN; ÇETİN, GÜVENPublication Metadata only Grade IV Glial Tümörlerde, Mitotik Aktivite, Ki-67 ve Platelet Volüm İndeksinin Prognostik Belirteç Olarak Karşılaştırılması(2019-08-01) Dündar, Tolga Turan; DÜNDAR, TOLGA TURANPublication Open Access Dexpanthenol and ascorbic acid ameliorate colistin-induced nephrotoxicity in rats.(2021-01-01T00:00:00Z) Aslan, T; Guler, E M; Dundar, T; Cakir, A; Gulgec, A S; Huseyinbas, O; Celikten, M; Coban, G; Hakyemez, I N; Kocyigit, ABDÜRRAHİM; Durdu, B; DÜNDAR, TOLGA TURAN; KOÇYİĞİT, ABDÜRRAHİMObjective: Colistin is a potent antibiotic which is mainly preferred in the treatment of multidrug-resistant (MDR) gram-negative bacilli. However, due to the increased risk of acute kidney injury following its use, the clinical application is limited. This nephrotoxicity is known to be induced by oxidative stress and related inflammation. In this study on rats, potent antioxidants Dexpanthenol (DEX) and Ascorbic acid (Vit C) have been administered in combination with Colistin to find out whether they would weaken Colistin's nephrotoxic effects. Materials and methods: Inflammation biomarkers were studied with enzyme-linked immunosorbent assay (ELISA) kits, and oxidative stress biomarkers were studied with different photometric methods in blood and tissue samples taken after treatment with DEX and Vit C in rats with colistin nephrotoxicity. In addition, inflammation and necrosis in the kidney tissues were examined pathologically. Results: It has been observed in the serum and tissue samples that DEX and Vit C decrease oxidative stress and inflammation biomarkers, therefore acting as nephroprotective agents. Conclusions: These compounds have been found to ameliorate the nephrotoxic effects of Colistin, which were demonstrated in the rats treated with Colistin, as well as the combinations.Publication Open Access Investigation of Brain Impairment Using Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Imaging in Experienced Healthy Divers.(2018-11-17) SEYITHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHIM SA; Dündar, TOLGA TURAN; KITIŞ, SERKAN; ARALAŞMAK, AYŞE; Gündağ, Papaker; SASANI, H; SEYİTHANOĞLU, MEHMET HAKAN; ABDALLAH, ANAS ABDELRAHıM SA; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; ARALAŞMAK, AYŞE; GUNDAG, MELİHABackground: The aim of this study was to understand the changes of decompression illness in healthy divers by comparing diffusion-weighted (DWI) and diffusion tensor MRI findings among healthy professional divers and healthy non-divers with no history of diving. Material/Methods: A total of 26 people were recruited in this prospective study: 11 experienced divers with no history of neurological decompression disease (cohort) and 15 healthy non-divers (control). In all study subjects, we evaluated apparent diffusion coefficient (ADC) and type of diffusion tensor metric fractional anisotropy (FA) values of different brain locations (e.g., frontal and parieto-occipital white matter, hippocampus, globus pallidus, putamen, internal capsule, thalamus, cerebral peduncle, pons, cerebellum, and corpus callosum). Results: ADC values of hippocampus were high in divers but low in the control group; FA values of globus pallidus and putamen were lower in divers compared to the control group. DWI depicted possible changes due to hypoxia in different regions of the brain. Statistically significant differences in ADC values were found in hypoxia, particularly in the hippocampus (p=0.0002), while FA values in the globus pallidus and putamen were statistically significant (p=0.015 and p=0.031, respectively). We detected forgetfulness in 6 divers and deterioration in fine-motor skills in 2 divers (p=0.002 and p=0.17, respectively). All of them were examined using neuro-psychometric tests. Conclusions: Repeated hyperbaric exposure increases the risk of white matter damage in experienced healthy divers without neurological decompression illness. The hippocampus, globus pallidus, and putamen are the brain areas responsible for memory, learning, navigation, and fine-motor skills and are sensitive to repeated hyperbaric exposurePublication Open Access Machine Learning-Based Surgical Planning for Neurosurgery: Artificial Intelligent Approaches to the Cranium(2022-04-01T00:00:00Z) Dündar, Tolga Turan; Yurtsever, İsmail; Kurt Pehlivanoğlu, Meltem; Yıldız, Uğur; Eker, Ayşegül; Demir, Mehmet Ali; Mutluer, Ahmet Serdar; Tektaş, Recep; Kazan, Mevlude Sila; Kitiş, Serkan; Gokoglu, Abdulkerim; Doğan, İhsan; Duru, Nevcihan; DÜNDAR, TOLGA TURAN; YURTSEVER, İSMAİL; KİTİŞ, SERKANObjectives: Artificial intelligence (AI) applications in neurosurgery have an increasing momentum as well as the growing number of implementations in the medical literature. In recent years, AI research define a link between neuroscience and AI. It is a connection between knowing and understanding the brain and how to simulate the brain. The machine learning algorithms, as a subset of AI, are able to learn with experiences, perform big data analysis, and fulfill human-like tasks. Intracranial surgical approaches that have been defined, disciplined, and developed in the last century have become more effective with technological developments. We aimed to define individual-safe, intracranial approaches by introducing functional anatomical structures and pathological areas to artificial intelligence. Methods: Preoperative MR images of patients with deeply located brain tumors were used for planning. Intracranial arteries, veins, and neural tracts are listed and numbered. Voxel values of these selected regions in cranial MR sequences were extracted and labeled. Tumor tissue was segmented as the target. Q-learning algorithm which is a model-free reinforcement learning algorithm was run on labeled voxel values (on optimal paths extracted from the new heuristic-based path planning algorithm), then the algorithm was assigned to list the cortico-tumoral pathways that aim to remove the maximum tumor tissue and in the meantime that functional anatomical tissues will be least affected. Results: The most suitable cranial entry areas were found with the artificial intelligence algorithm. Cortico-tumoral pathways were revealed using Q-learning from these optimal points. Conclusions: AI will make a significant contribution to the positive outcomes as its use in both preoperative surgical planning and intraoperative technique equipment assisted neurosurgery, its use increasedPublication Metadata only Comparison of TOF MRA, Contrast-Enhanced MRA and Subtracted CTA from CTP in Residue Evaluation of Treated Intracranial Aneurysms(2018-01-01) Dundar, TOLGA TURAN; Kits, Serkan; Ozdemir, HÜSEYİN; Seyithanoglu, MEHMET HAKAN; Uysal, Omer; Toprak, HÜSEYİN; Ozek, ERDİNÇ; Alkan, ALPAY; DÜNDAR, TOLGA TURAN; ARALAŞMAK, AYŞE; ÖZDEMİR, HÜSEYIN; SEYİTHANOĞLU, MEHMET HAKAN; UYSAL, ÖMER; TOPRAK, HÜSEYİN; KİTİŞ, SERKAN; ÖZEK, ERDİNÇ; ALKAN, ALPAYAIM: To compare effectiveness of contrast-enhanced magnetic resonance angiography (CE-MRA), 3D-Time-of-flight magnetic resonance angiography (3D-TOF-MRA) and subtracted computed tomography angiography from computed tomography perfusion (sub-CTA) in residue evaluation of intracranial aneurysms treated either with coiling or clipping.