Person: YENİGÜN, VILDAN BETÜL
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Publication Metadata only Response of CD44+/CD24-/low breast cancer stem/progenitor cells to tamoxifen‑ and doxorubicin‑induced autophagy.(2013-06-01T00:00:00Z) Yenigun, VİLDAN BETÜL; OZPOLAT, B; KOSE, GT; YENİGÜN, VILDAN BETÜLPublication Metadata only Diklofenak Sodyum, İbuprofen ve Parasetamol İçeren Nazal Analjezik Spreylerin Formülasyonu ve İn Vitro Toksisitesinin Değerlendirilmesi(2022-11-16) Yenigün A.; Sütcü A. O.; Yenigün V. B.; Sağıroğlu A. A.; Koçyiğit A.; Özturan O.; YENİGÜN, ALPER; SÜTÇÜ, AHMET ONUR; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; ÖZTURAN, ORHANPublication Metadata only NF-kappa B Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer(2019-09-01) Eskandari, Zahra; BAHADORİ, FATEMEH; Yapaoz, Melda Altkatoglu; Yenign, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; Onyuksel, Hayat; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMThis study aims to investigate the effects of co-administration of nano-Curcumin on anticancer effect of nano-Pirarubicin considering the fact that the clinical use of Pirarubicin and other anthracyclines has been limited by development of multidrug resistance (MDR) and based on previous data which have shown that Curcumin can down-regulate MDR proteins and suppress the activity of Nuclear factor-kappa B (NF-kappa B) a protein involved in chemoresistance. Nano micellar formulations of both Curcumin and Pirarubicin were separately synthesized using 1,2 -Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-[poly (ethylene glycol); PEG MW 2,000] (DSPE-PEG2000). The produced sterically stabilized micelles (SSM) are very well known drug delivery systems in terms of their enhanced efficacy and good toxicity profile. We measured the differences of NF-kappa B levels in two different situations: when Pirarubicin is used alone and when it is co-administered with Curcumin. This study showed that co-administration of SSM-Curcumin (CSSM) and SSM-Pirarubicin (PSSM) with size of 12.81 nm enhances the efficacy of Pirarubicin by suppressing P65, an NF-kappa B subunit. Furthermore, we showed that SSM is able to successfully enhance water solubility and therapeutic stability of curcumin for using as a complementary agent.Publication Metadata only Hedera helix (Wall Ivy) leaf ethanol extract shows cytotoxic and apoptotic effects in glioblastoma cells by generating reactive oxygen species(2023-12-01) Yenigün V. B.; Koçyiğit A.; Kanımdan E.; Durmuş E.; Köktaşoğlu F.; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; KANIMDAN, EBRU; BALKAN, EZGİ; KÖKTAŞOĞLU, FATMANUR