Person: YENİGÜN, VILDAN BETÜL
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Publication Open Access Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients(2021-06-01T00:00:00Z) Kocyigit, Abdurrahim; Sogut, Ozgur; Kanimdan, Ebru; Guler, Eray Metin; Kaplan, Onur; Eren, Canan; Ozman, Zeynep; Yasar, Oznur; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; KANIMDAN, EBRU; YENİGÜN, VILDAN BETÜL; ÖZMAN, ZEYNEPCoronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls (p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity (r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.Publication Metadata only Diklofenak Sodyum, İbuprofen ve Parasetamol İçeren Nazal Analjezik Spreylerin Formülasyonu ve İn Vitro Toksisitesinin Değerlendirilmesi(2022-11-16) Yenigün A.; Sütcü A. O.; Yenigün V. B.; Sağıroğlu A. A.; Koçyiğit A.; Özturan O.; YENİGÜN, ALPER; SÜTÇÜ, AHMET ONUR; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; ÖZTURAN, ORHANPublication Metadata only Hedera helix (Wall Ivy) leaf ethanol extract shows cytotoxic and apoptotic effects in glioblastoma cells by generating reactive oxygen species(2023-12-01) Yenigün V. B.; Koçyiğit A.; Kanımdan E.; Durmuş E.; Köktaşoğlu F.; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; KANIMDAN, EBRU; BALKAN, EZGİ; KÖKTAŞOĞLU, FATMANUR