Person: YENİGÜN, VILDAN BETÜL
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Publication Metadata only Levan enhanced the NF-κB suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment.(2021-08-19T00:00:00Z) Eskandari, Zahra; Bahadori, Fatemeh; Yenigun, Vildan Betül; Demiray, Mutlu; Eroğlu, Mehmet Sayip; Kocyigit, Abdurrahim; Oner, Ebru Toksoy; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients(2021-06-01T00:00:00Z) Kocyigit, Abdurrahim; Sogut, Ozgur; Kanimdan, Ebru; Guler, Eray Metin; Kaplan, Onur; Eren, Canan; Ozman, Zeynep; Yasar, Oznur; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; KANIMDAN, EBRU; YENİGÜN, VILDAN BETÜL; ÖZMAN, ZEYNEPCoronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls (p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity (r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.Publication Metadata only Rheum ribes L.’nin etanol ekstraktlarının malign melanomahücreleri üzerine anti-kanser etkinliği(2020-03-01T00:00:00Z) KİRMİT, ADNAN; TAKIM, KASIM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VİLDAN BETÜL; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Response of CD44+/CD24-/low breast cancer stem/progenitor cells to tamoxifen‑ and doxorubicin‑induced autophagy.(2013-06-01T00:00:00Z) Yenigun, VİLDAN BETÜL; OZPOLAT, B; KOSE, GT; YENİGÜN, VILDAN BETÜLPublication Metadata only Comparison of Chondrocytes Produced from Adipose Tissue-Derived Stem Cells and Cartilage Tissue(2013-05-01) Yenigun, Vildan Betul; MERIC, Aysenur; Yenigun, ALPER; Dogan, REMZİ; Ozturan, ORHAN; YENİGÜN, ALPER; YENİGÜN, VILDAN BETÜL; DOĞAN, REMZI; ÖZTURAN, ORHANObjective: Spontaneous cartilage regeneration is poor after a cartilage defect occurs by trauma, surgical, and other reasons. Importance of producing chondrocytes from stem cells and using tissues to repair a defect is getting popular. The aim of this study was to compare the effects of injectable cartilage produced by chondrocytes differentiated from adipose tissue-derived mesenchymal stem cells and chondrocyte cells isolated directly from cartilage tissue.Publication Metadata only Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles.(2021-04-02T00:00:00Z) Bahadori, Fatemeh; Yenigun, Vildan Betul; Celikten, Mert; Kocyigit, ABDÜRRAHİM; Onyuksel, Hayat; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Investigating the Cytotoxicity of Dual-Cure Bulk-Fill Resin Materials on L929 Cells(2022-08-01T00:00:00Z) Köymen, Safiye Selin; Dönmez, Nazmiye; Yenigün, Vildan Betül; Bahadori, Fatemeh; Koçyiğit, Abdürrahim; DÖNMEZ, NAZMİYE; YENİGÜN, VILDAN BETÜL; BAHADORİ, FATEMEH; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only A Preliminary Research Study on the Cytotoxicity of Expired and Non-expired Composite Resins: In Vitro Study(2020-01-01T00:00:00Z) KAZAK, MAĞRUR; DÖNMEZ, NAZMİYE; BAHADORI, FATEMEH; YENİGÜN, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; DÖNMEZ, NAZMİYE; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Use of Topical Tranexamic Acid to Reduce Drainage Output After Thyroidectomy(2022-04-01T00:00:00Z) AKSOY, FADLULLAH; YENİGÜN, ALPER; YENİGÜN, Vildan Betül; Goktas, Seda Sezen; Ozdem, Abdullah; DOĞAN, Remzi; ÖZTURAN, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; YENİGÜN, VILDAN BETÜL; ÖZDEM, ABDULLAH; DOĞAN, REMZI; ÖZTURAN, ORHANObjective: Thyroid surgery is one of the frequent surgeries in daily operation schedules more often since the thyroid gland is very vascular Hematomas after thyroidectomy may cause airway obstruction, which is life-threatening and requires immediate surgical intervention. Therefore, many hemostatic devices and methods have been developed. Tranexamic acid is a synthetic lysine analog with low molecular weight. This study was planned to demonstrate the effect of intraoperative topical tranexamic acid on postoperative drainage output for thyroid surgery.Publication Metadata only NF-kappa B Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer(2019-09-01) Eskandari, Zahra; BAHADORİ, FATEMEH; Yapaoz, Melda Altkatoglu; Yenign, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; Onyuksel, Hayat; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMThis study aims to investigate the effects of co-administration of nano-Curcumin on anticancer effect of nano-Pirarubicin considering the fact that the clinical use of Pirarubicin and other anthracyclines has been limited by development of multidrug resistance (MDR) and based on previous data which have shown that Curcumin can down-regulate MDR proteins and suppress the activity of Nuclear factor-kappa B (NF-kappa B) a protein involved in chemoresistance. Nano micellar formulations of both Curcumin and Pirarubicin were separately synthesized using 1,2 -Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-[poly (ethylene glycol); PEG MW 2,000] (DSPE-PEG2000). The produced sterically stabilized micelles (SSM) are very well known drug delivery systems in terms of their enhanced efficacy and good toxicity profile. We measured the differences of NF-kappa B levels in two different situations: when Pirarubicin is used alone and when it is co-administered with Curcumin. This study showed that co-administration of SSM-Curcumin (CSSM) and SSM-Pirarubicin (PSSM) with size of 12.81 nm enhances the efficacy of Pirarubicin by suppressing P65, an NF-kappa B subunit. Furthermore, we showed that SSM is able to successfully enhance water solubility and therapeutic stability of curcumin for using as a complementary agent.