Person: YENİGÜN, VILDAN BETÜL
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Publication Metadata only Evaluating Cytotoxic Effects and Cytotoxicity Origins of Bulk-Fill Materials by LC-MS/MS.-(2022-09-17T00:00:00Z) Kazak, Mağrur; Dönmez, Nazmiye; Bahadori, Fatemeh; Yenigün, Vildan Betül; Koçyiğit, Abdürrahim; DÖNMEZ, NAZMİYE; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Levan enhanced the NF-κB suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment.(2021-08-19T00:00:00Z) Eskandari, Zahra; Bahadori, Fatemeh; Yenigun, Vildan Betül; Demiray, Mutlu; Eroğlu, Mehmet Sayip; Kocyigit, Abdurrahim; Oner, Ebru Toksoy; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients(2021-06-01T00:00:00Z) Kocyigit, Abdurrahim; Sogut, Ozgur; Kanimdan, Ebru; Guler, Eray Metin; Kaplan, Onur; Eren, Canan; Ozman, Zeynep; Yasar, Oznur; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; KANIMDAN, EBRU; YENİGÜN, VILDAN BETÜL; ÖZMAN, ZEYNEPCoronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls (p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity (r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.Publication Metadata only Rheum ribes L.’nin etanol ekstraktlarının malign melanomahücreleri üzerine anti-kanser etkinliği(2020-03-01T00:00:00Z) KİRMİT, ADNAN; TAKIM, KASIM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VİLDAN BETÜL; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Quercus Pyrenaica Honeydew Honey Induces DNA Damage, Apoptosis and Cell Death Through Generation of Reactive Oxygen Species in Gastric Cancer Cells(2018-06-26T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Aydoğdu, Gökhan; BALKAN, EZGİ; YENİGÜN, VİLDAN BETÜL; DEDEAKAYOĞULLARI, HURİ; GÜLER, ERAY METİN; KÖKTAŞOĞLU, FATMANUR; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; KÖKTAŞOĞLU, FATMANURPublication Metadata only Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles.(2021-04-02T00:00:00Z) Bahadori, Fatemeh; Yenigun, Vildan Betul; Celikten, Mert; Kocyigit, ABDÜRRAHİM; Onyuksel, Hayat; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Investigating the Cytotoxicity of Dual-Cure Bulk-Fill Resin Materials on L929 Cells(2022-08-01T00:00:00Z) Köymen, Safiye Selin; Dönmez, Nazmiye; Yenigün, Vildan Betül; Bahadori, Fatemeh; Koçyiğit, Abdürrahim; DÖNMEZ, NAZMİYE; YENİGÜN, VILDAN BETÜL; BAHADORİ, FATEMEH; KOÇYİĞİT, ABDÜRRAHİMPublication Unknown Diklofenak Sodyum, İbuprofen ve Parasetamol İçeren Nazal Analjezik Spreylerin Formülasyonu ve İn Vitro Toksisitesinin Değerlendirilmesi(2022-11-16) Yenigün A.; Sütcü A. O.; Yenigün V. B.; Sağıroğlu A. A.; Koçyiğit A.; Özturan O.; YENİGÜN, ALPER; SÜTÇÜ, AHMET ONUR; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; ÖZTURAN, ORHANPublication Unknown Farklı kullanım tarihine sahip kompozitlerin sitotoksisitelerinin in vitro araştırılması : Pilot Çalışma(2017-09-24T00:00:00Z) KAZAK, MAĞRUR; DÖNMEZ, NAZMİYE; BAHADORI, FATEMEH; YENİGÜN, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; DÖNMEZ, NAZMİYE; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Unknown Kronik Enflamasyon: Moleküler Patofizyoloji, Beslenme ve Terapötik Girişimler(2019-04-01T00:00:00Z) Koçyiğit, Abdurrahim; Yenigün, Vildan Betül; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM