Person: YENİGÜN, VILDAN BETÜL
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Publication Metadata only Levan enhanced the NF-κB suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment.(2021-08-19T00:00:00Z) Eskandari, Zahra; Bahadori, Fatemeh; Yenigun, Vildan Betül; Demiray, Mutlu; Eroğlu, Mehmet Sayip; Kocyigit, Abdurrahim; Oner, Ebru Toksoy; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Rheum ribes L.’nin etanol ekstraktlarının malign melanomahücreleri üzerine anti-kanser etkinliği(2020-03-01T00:00:00Z) KİRMİT, ADNAN; TAKIM, KASIM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VİLDAN BETÜL; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Response of CD44+/CD24-/low breast cancer stem/progenitor cells to tamoxifen‑ and doxorubicin‑induced autophagy.(2013-06-01T00:00:00Z) Yenigun, VİLDAN BETÜL; OZPOLAT, B; KOSE, GT; YENİGÜN, VILDAN BETÜLPublication Metadata only Comparison of Chondrocytes Produced from Adipose Tissue-Derived Stem Cells and Cartilage Tissue(2013-05-01) Yenigun, Vildan Betul; MERIC, Aysenur; Yenigun, ALPER; Dogan, REMZİ; Ozturan, ORHAN; YENİGÜN, ALPER; YENİGÜN, VILDAN BETÜL; DOĞAN, REMZI; ÖZTURAN, ORHANObjective: Spontaneous cartilage regeneration is poor after a cartilage defect occurs by trauma, surgical, and other reasons. Importance of producing chondrocytes from stem cells and using tissues to repair a defect is getting popular. The aim of this study was to compare the effects of injectable cartilage produced by chondrocytes differentiated from adipose tissue-derived mesenchymal stem cells and chondrocyte cells isolated directly from cartilage tissue.Publication Metadata only Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles.(2021-04-02T00:00:00Z) Bahadori, Fatemeh; Yenigun, Vildan Betul; Celikten, Mert; Kocyigit, ABDÜRRAHİM; Onyuksel, Hayat; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Investigating the Cytotoxicity of Dual-Cure Bulk-Fill Resin Materials on L929 Cells(2022-08-01T00:00:00Z) Köymen, Safiye Selin; Dönmez, Nazmiye; Yenigün, Vildan Betül; Bahadori, Fatemeh; Koçyiğit, Abdürrahim; DÖNMEZ, NAZMİYE; YENİGÜN, VILDAN BETÜL; BAHADORİ, FATEMEH; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only A Preliminary Research Study on the Cytotoxicity of Expired and Non-expired Composite Resins: In Vitro Study(2020-01-01T00:00:00Z) KAZAK, MAĞRUR; DÖNMEZ, NAZMİYE; BAHADORI, FATEMEH; YENİGÜN, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; DÖNMEZ, NAZMİYE; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only NF-kappa B Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer(2019-09-01) Eskandari, Zahra; BAHADORİ, FATEMEH; Yapaoz, Melda Altkatoglu; Yenign, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; Onyuksel, Hayat; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMThis study aims to investigate the effects of co-administration of nano-Curcumin on anticancer effect of nano-Pirarubicin considering the fact that the clinical use of Pirarubicin and other anthracyclines has been limited by development of multidrug resistance (MDR) and based on previous data which have shown that Curcumin can down-regulate MDR proteins and suppress the activity of Nuclear factor-kappa B (NF-kappa B) a protein involved in chemoresistance. Nano micellar formulations of both Curcumin and Pirarubicin were separately synthesized using 1,2 -Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-[poly (ethylene glycol); PEG MW 2,000] (DSPE-PEG2000). The produced sterically stabilized micelles (SSM) are very well known drug delivery systems in terms of their enhanced efficacy and good toxicity profile. We measured the differences of NF-kappa B levels in two different situations: when Pirarubicin is used alone and when it is co-administered with Curcumin. This study showed that co-administration of SSM-Curcumin (CSSM) and SSM-Pirarubicin (PSSM) with size of 12.81 nm enhances the efficacy of Pirarubicin by suppressing P65, an NF-kappa B subunit. Furthermore, we showed that SSM is able to successfully enhance water solubility and therapeutic stability of curcumin for using as a complementary agent.Publication Metadata only Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila.(2014-01-30T00:00:00Z) FAN, Y; WANG, S; HERNANDEZ, J; Yenigun, VİLDAN BETÜL; HERTLEIN, G; FOGARTY, CE; LINDBLAD, JL; Bergmann, Andreas; YENİGÜN, VILDAN BETÜLPublication Metadata only Alcoholic extract of Tarantula cubensis (Theranekron®) induce autophagy on gastric cancer cells(2021-03-01T00:00:00Z) YENİGÜN, VİLDAN BETÜL; Azzawri, Ali Ahmed; Acar, Mustafa Said; Kaplan, Muhammed Burak; Uçar, Vasfiye Betül; TAŞTEKİN, DİDEM; ACAR, HASAN; YENİGÜN, VILDAN BETÜL