Person: YENİGÜN, VILDAN BETÜL
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Publication Open Access Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients(2021-06-01T00:00:00Z) Kocyigit, Abdurrahim; Sogut, Ozgur; Kanimdan, Ebru; Guler, Eray Metin; Kaplan, Onur; Eren, Canan; Ozman, Zeynep; Yasar, Oznur; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; KANIMDAN, EBRU; YENİGÜN, VILDAN BETÜL; ÖZMAN, ZEYNEPCoronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls (p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity (r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.Publication Metadata only Rheum ribes L.’nin etanol ekstraktlarının malign melanomahücreleri üzerine anti-kanser etkinliği(2020-03-01T00:00:00Z) KİRMİT, ADNAN; TAKIM, KASIM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VİLDAN BETÜL; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Quercus Pyrenaica Honeydew Honey Induces DNA Damage, Apoptosis and Cell Death Through Generation of Reactive Oxygen Species in Gastric Cancer Cells(2018-06-26T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Aydoğdu, Gökhan; BALKAN, EZGİ; YENİGÜN, VİLDAN BETÜL; DEDEAKAYOĞULLARI, HURİ; GÜLER, ERAY METİN; KÖKTAŞOĞLU, FATMANUR; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; KÖKTAŞOĞLU, FATMANURPublication Metadata only In Vitro Antioxidant and Anticancer Activities of Some Local Plants from Bolu Province of Turkey(2017-11-11) Kasapoğlu, Kadriye Nur; KOÇYİĞİT, ABDÜRRAHİM; YENİGÜN, VİLDAN BETÜL; BALKAN, EZGİ; Demircan, Evren; Karbancıoğlu-Güler , Funda; Özçelik, Beraat; KOÇYİĞİT, ABDÜRRAHİM; YENİGÜN, VILDAN BETÜL; BALKAN, EZGİPublication Open Access Quercus pyrenaica Honeydew Honey With High Phenolic Contents Cause DNA Damage, Apoptosis, and Cell Death Through Generation of Reactive Oxygen Species in Gastric Adenocarcinoma Cells(2019-09-01) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; GÜLER, Eray Metin; BULUT, HURİ; KÖKTAŞOĞLU, FATMANUR; Goeren, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHANMany studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent studies have demonstrated that honey can be used for the treatment of cancer as well as cancer prevention. Antineoplastic effects of honey are often associated with their antioxidant phenolic contents. However, very few studies have dealt with the association of phenolic contents of honeys in terms of antiproliferative effects. The aim of this study was, therefore, to elucidate the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating effects of honey samples on the basis of their phenolic and flavonoid contents. Fourteen different honey varieties were collected from various parts of Turkey, and their characteristics regarding total phenols, flavonoids, and antioxidant contents were determined to test their effects on gastric cancer cells (AGS). For convenience, 2 honey varieties were selected, namely, Ida Mountains Quercus pyrenaica honeydew honey (QPHH-IM) having the highest phenolic and antioxidant content and Canakkale multifloral honey (MFH-C) with the lowest phenolic and antioxidant content. Levels of 11 different phenolic compounds in QPHH-IM and MFH-C samples were determined by LC-MS/MS. AGS cells were incubated with different concentrations of QPHH-IM and MFH-C for 24 hours, then the cell viability, DNA damage, apoptosis, and generation of ROS were determined. We found that QPHH-IM had more cytotoxic, genotoxic, and apoptotic effects than that of MFH-C. We think that these effects are probably related to pro-oxidant activities due to the high phenolic contents present. Therefore, further research on high-phenolic honey may contribute to the future development of cancer therapeutics.Publication Metadata only The Acorn Honey Used for a Published Study was Mistakenly Listed as Quercus pyrenaica and Should Be Corrected to Quercus species(2022-07-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; YENİGÜN, Vildan Betül; GÜLER, ERAY METİN; BULUT, Huri; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN