Person: YENİGÜN, VILDAN BETÜL
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Publication Metadata only Evaluating Cytotoxic Effects and Cytotoxicity Origins of Bulk-Fill Materials by LC-MS/MS.-(2022-09-17T00:00:00Z) Kazak, Mağrur; Dönmez, Nazmiye; Bahadori, Fatemeh; Yenigün, Vildan Betül; Koçyiğit, Abdürrahim; DÖNMEZ, NAZMİYE; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Nazal polip oluşumunda viral etyoloji(2014-04-14) YENİGÜN, ALPER; DOĞAN, REMZİ; YENİGÜN, VİLDAN BETÜL; AKSOY, FADLULLAH; YILMAZ, FAHRETTİN; OZTURAN, ORHAN; YENİGÜN, ALPER; DOĞAN, REMZI; YENİGÜN, VILDAN BETÜL; AKSOY, FADLULLAH; ÖZTURAN, ORHANPublication Metadata only Levan enhanced the NF-κB suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment.(2021-08-19T00:00:00Z) Eskandari, Zahra; Bahadori, Fatemeh; Yenigun, Vildan Betül; Demiray, Mutlu; Eroğlu, Mehmet Sayip; Kocyigit, Abdurrahim; Oner, Ebru Toksoy; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients(2021-06-01T00:00:00Z) Kocyigit, Abdurrahim; Sogut, Ozgur; Kanimdan, Ebru; Guler, Eray Metin; Kaplan, Onur; Eren, Canan; Ozman, Zeynep; Yasar, Oznur; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; KANIMDAN, EBRU; YENİGÜN, VILDAN BETÜL; ÖZMAN, ZEYNEPCoronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls (p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity (r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.Publication Metadata only Rheum ribes L.’nin etanol ekstraktlarının malign melanomahücreleri üzerine anti-kanser etkinliği(2020-03-01T00:00:00Z) KİRMİT, ADNAN; TAKIM, KASIM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VİLDAN BETÜL; BULUT, HURİ; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; GÜLER, ERAY METİN; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Response of CD44+/CD24-/low breast cancer stem/progenitor cells to tamoxifen‑ and doxorubicin‑induced autophagy.(2013-06-01T00:00:00Z) Yenigun, VİLDAN BETÜL; OZPOLAT, B; KOSE, GT; YENİGÜN, VILDAN BETÜLPublication Metadata only Comparison of Chondrocytes Produced from Adipose Tissue-Derived Stem Cells and Cartilage Tissue(2013-05-01) Yenigun, Vildan Betul; MERIC, Aysenur; Yenigun, ALPER; Dogan, REMZİ; Ozturan, ORHAN; YENİGÜN, ALPER; YENİGÜN, VILDAN BETÜL; DOĞAN, REMZI; ÖZTURAN, ORHANObjective: Spontaneous cartilage regeneration is poor after a cartilage defect occurs by trauma, surgical, and other reasons. Importance of producing chondrocytes from stem cells and using tissues to repair a defect is getting popular. The aim of this study was to compare the effects of injectable cartilage produced by chondrocytes differentiated from adipose tissue-derived mesenchymal stem cells and chondrocyte cells isolated directly from cartilage tissue.Publication Metadata only Quercus Pyrenaica Honeydew Honey Induces DNA Damage, Apoptosis and Cell Death Through Generation of Reactive Oxygen Species in Gastric Cancer Cells(2018-06-26T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Aydoğdu, Gökhan; BALKAN, EZGİ; YENİGÜN, VİLDAN BETÜL; DEDEAKAYOĞULLARI, HURİ; GÜLER, ERAY METİN; KÖKTAŞOĞLU, FATMANUR; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; KÖKTAŞOĞLU, FATMANURPublication Metadata only Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles.(2021-04-02T00:00:00Z) Bahadori, Fatemeh; Yenigun, Vildan Betul; Celikten, Mert; Kocyigit, ABDÜRRAHİM; Onyuksel, Hayat; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Investigating the Cytotoxicity of Dual-Cure Bulk-Fill Resin Materials on L929 Cells(2022-08-01T00:00:00Z) Köymen, Safiye Selin; Dönmez, Nazmiye; Yenigün, Vildan Betül; Bahadori, Fatemeh; Koçyiğit, Abdürrahim; DÖNMEZ, NAZMİYE; YENİGÜN, VILDAN BETÜL; BAHADORİ, FATEMEH; KOÇYİĞİT, ABDÜRRAHİM