Person: BALLI, UMUT
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Publication Metadata only Assessment of Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 in the Periodontium of Rats Treated With Atorvastatin(2014-01-01T00:00:00Z) Balli, UMUT; Keles, Gonca Cayir; Cetinkaya, Burcu Ozkan; Mercan, Ugur; Ayas, Bulent; Erdogan, Deniz; BALLI, UMUTBackground: The aim of this study is to examine, for the first time, the role of systemic and local atorvastatin application on periodontium using histomorphometric and immunohistochemical analysis during and after experimental periodontitis induction with or without the presence of microbial dental biofilm.Publication Metadata only Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol(2016-04-01T00:00:00Z) Balli, UMUT; Cetinkaya, Burcu Ozkan; Keles, Gonca Cayir; Keles, Zeynep Pinar; Guler, Sevki; Sogut, Mehtap Unlu; Erisgin, Zuleyha; BALLI, UMUTPurpose: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the periodontium by histomorphometric analysis and on gingival tissue matrix metalloproteinase-1 (MMP-1), MMP-8, and tissue inhibitor of metalloproteinase-2 (TIMP-2) by biochemical analysis of rats after experimental periodontitis induction.Publication Metadata only Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases(2016-12-01T00:00:00Z) Turer, Cigdem Coskun; Balli, UMUT; Guven, Berrak; Cetinkaya, Burcu Ozkan; Keles, Gonca Cayir; BALLI, UMUTThe purpose of this study was to evaluate visfatin levels at different stages of periodontal disease and in healthy tissues. In addition, the effect of non-surgical periodontal therapy on visfatin levels in gingival crevicular fluid and serum was investigated. Forty-five patients were divided into three groups based on clinical and radiographical findings. Group I comprised periodontally healthy individuals (n = 15); group 2 comprised patients with gingivitis (n = 15); and group 3 was composed of patients with generalized chronic periodontitis (n = 15). Gingival crevicular fluid and serum samples were collected before treatment and at 1, 3, and 6 months after treatment. Visfatin levels were measured by enzyme linked immunosorbent assays. Gingival crevicular fluid and serum visfatin levels were higher in patients with chronic periodontitis than those with gingivitis or healthy controls (P < 0.016). In addition, visfatin levels were higher in the gingivitis group than in healthy controls (P < 0.016). Non-surgical periodontal treatment resulted in a significant reduction in gingival crevicular fluid and serum visfatin levels. Furthermore, visfatin levels increased with inflammation and decreased following periodontal treatment. Our findings suggest that visfatin is an inflammatory biomarker of periodontal disease.Publication Metadata only Autogenous cortical bone and bioactive glass grafting for treatment of intraosseous periodontal defects.(2013-01-01T00:00:00Z) Sumer, Mahmut; Keles, Gonca Cayir; Cetinkaya, Burcu Ozkan; Balli, UMUT; Pamuk, Ferda; Uckan, Sina; BALLI, UMUTPublication Metadata only Long-term clinical results on the use of platelet concentrate in the treatment of intrabony periodontal defects(2014-02-01T00:00:00Z) Cetinkaya, Burcu Ozkan; Keles, Gonca Cayir; Pamuk, Ferda; Balli, UMUT; Keles, Zeynep Pinar; BALLI, UMUTObjective. The purpose of this clinical investigation was to evaluate long-term results obtained with the combination of platelet pellet(PP) plus bioabsorbable barriermembrane(BM) and to compare this outcome with the results obtained using bioactive glass (BG) graft material with a BM. Materials and methods. Using a split mouth design, 11 chronic periodontitis patients (power >= at least 80%) were randomly assigned to treatment with a combination of PP/GTR or BG/GTR in contra-lateral dentition areas. Clinical attachment level (CAL) as the primary outcome variable, calculated as the sum of probing pocket depth (PPD) and gingival recession, and radiological alveolar bone level were recorded at baseline, 6 months and 5 years. Results. There were no statistical differences between test and control defects at baseline. PPD reductions and CAL and radiological alveolar bone height gains were statistically significant between baseline and 6 months and between baseline and 5 years in both groups (p= 4 mm CAL gain in both groups, while 5 year results showed that 73% of the defects attained 2 mm 0.05). No statistically significant difference in any of the clinical parameters was observed at 6 months and 5 years between the groups (p > 0.05). Conclusions. The long-term efficacy of platelet concentrate combined with a barrier membrane is similar with the combination of bioactive glass graft material and barrier membrane, suggesting that results obtained with both treatment approaches can be maintained over a period of 5 years.Publication Metadata only Biochemical Analysis of Pentraxin 3 and Fibrinogen Levels in Experimental Periodontitis Model(2012-01-01T00:00:00Z) Keles, Gonca Cayir; Balli, UMUT; Cetinkaya, Burcu Ozkan; Ayas, Bulent; Findik, Arzu; Keles, Zeynep Pinar; Pamuk, Ferda; BALLI, UMUTObjective. Pentraxin 3 (PTX3), newly discovered inflammation marker, is a member of acute-phase proteins. The hypothesis, synthesis of gingival tissue and serum PTX-3 increases in the experimental periodontitis model (with 10-day and 40-day periods), was tested by detecting gingival tissue and serum PTX-3 levels in rats with experimental periodontitis. Methods. Thirty rats were randomly divided into three groups of ten animals each: ligature-induced experimental periodontitis groups (with 10-day (Group1) and 40-day periods (Group2)) and healthy group (Group3). At the end of experimental period, rats were sacrificed, and radiological and histomorphometric analyses were performed on the mandibles. PTX3 levels were measured in gingival tissue and serum samples using ELISA. Plasma fibrinogen levels were measured according to the nephelometric method. Results. Significant alveolar bone resorption and periodontal inflammation were evident in periodontitis groups. Levels of PTX3 in gingival tissue were statistically higher in Group 1 than those in groups 2 and 3 (P 0.05). Plasma fibrinogen levels were significantly increased in the experimental periodontitis groups (P < 0.001). Conclusion. PTX3 seems to be associated with tissue destruction in earlier periods of inflammatory periodontal disease, contrary to the fibrinogen findings.