Person: DURDU, BÜLENT
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Publication Metadata only Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study(2022-10-01T00:00:00Z) Cakir, Ahsen; Bozali, Kubra; Celikten, Mert; Guler, Eray Metin; Sahan, Ebru; DURDU, BÜLENT; SÜMBÜL, BİLGE; KOÇYİĞİT, ABDÜRRAHİM; ŞAHAN, EBRU; DURDU, BÜLENT; SÜMBÜL, BİLGE; KOÇYİĞİT, ABDÜRRAHİMSince most infectious diseases can develop into sepsis, it is still a major medical problem. Some in-vivo studies showed promising properties of fluoxetine in the treatment of infections. This study aims the antimicrobial effect of fluoxetine on the inflammatory process used in the treatment of sepsis-modeled rats. Besides, to investigate the efficacy of fluoxetine on modifying the antibiotic effect of imipenem in the inflammatory response. An experimental sepsis model was divided into negative control, positive control, fluoxetine 5 mg/kg, imipenem 60 mg/kg, and combined (fluoxetine; imipenem). Procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), lactate, myeloperoxidase activity (MPO), the inflammation markers interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1) levels were measured by enzyme-linked immunosorbent assay method. Oxidative stress markers, total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), and native thiol (NT) were measured using photometric methods. Oxidative stress index (OSI) was calculated according to TAS and TOS levels. The statistical analysis was performed by Statistical Package for Social Sciences version 22.0. After treatment with fluoxetine, imipenem, and combined groups, IL-1 beta, IL-6, TNF-alpha, MPO activity, MCP-1, hs-CRP, PCT, lactate, and the oxidative stress markers OSI, and disulfide levels were decreased (p < 0.05). The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti-inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model.Publication Metadata only Utility of Rapid Antibody Test for Screening COVID-19 Among Healthcare Professionals(2020-10-01T00:00:00Z) Okay, Gulay; Kacmaz, Asiye Bahar; Sumbul, BİLGE; Bolukcu, Sibel; Akkoyunlu, Yasemin; Meric Koc, Meliha; SÜMBÜL, BİLGE; OKAY, GÜLAY; DURDU, BÜLENT; AKKOYUNLU, YASEMİNObjective: This study aims to assess the effectivity of a rapid antibody test on detecting the occupational exposure in healthcare professionals who have been working in a pandemic hospital since the initial cases were seen in our country.Publication Metadata only Covid-19-un akut böbrek hasar belirteçleri uzerine etkisi(2022-05-25T00:00:00Z) Akkoyunlu, Yasemin; Koçyiğit, Abdürrahim; Elçioğlu, Ömer Celal; Güler, Eray Metin; Sümbül, Bilge; Okay, Gülay; Durdu, Bülent; Bolukçu, Sibel; Kazancıoğlu, Rümeyza; Aslan, Turan; AKKOYUNLU, YASEMİN; KOÇYİĞİT, ABDÜRRAHİM; ELÇİOĞLU, ÖMER CELAL; SÜMBÜL, BİLGE; OKAY, GÜLAY; DURDU, BÜLENT; KAZANCIOĞLU, RÜMEYZA; ASLAN, TURANPublication Metadata only Efficacy of Tocilizumab in Patients with a Moderate and Severe COVID-19: A Retrospective Single Center Cohort Study(2021-11-01T00:00:00Z) Karakuş, Hatice Dilara; Okay, Gülay; Akkoyunlu, Yasemin; Sümbül, Bilge; Durdu, Bülent; Meriç Koç, Meliha; Aslan, Turan; KARAKUŞ, HATİCE DİLARA; OKAY, GÜLAY; AKKOYUNLU, YASEMİN; SÜMBÜL, BİLGE; DURDU, BÜLENT; MERİÇ KOÇ, MELİHA; ASLAN, TURANPublication Metadata only The Effects of Polypharmacy, Nutritional and Functional Status on the Progression of COVID-19 in Older Adults(2021-08-01T00:00:00Z) Ogun, Hamza; Akkoyunlu, Yasemin; Durdu, Bülent; Okyaltırık, Fatmanur; Kazancıoğlu, Rümeyza; Meriç Koç, Meliha; Gülen, Bedia; Sümbül, Bilge; Okay, Gülay; Bolukcu, Sibel; Sönmez, Ertan; Kaçmaz, Asiye Bahar; Soysal, Pınar; Tan, Semen Gökçe; SOYSAL, PINAR; DURDU, BÜLENT; AKKOYUNLU, YASEMİN; OGUN, HAMZA; OKYALTIRIK, FATMANUR; OKAY, GÜLAY; SÜMBÜL, BİLGE; SÖNMEZ, ERTAN; MERİÇ KOÇ, MELİHA; KAZANCIOĞLU, RÜMEYZAPublication Metadata only Thorax computed tomography findings and anti-SARS-CoV-2 immunoglobulin G levels in polymerase chain reaction-negative probable COVID-19 cases.(2022-11-25) Yurtsever I.; Karatoprak C.; Sumbul B.; Kiskac M.; Tunc M.; Zorlu M.; Ogun H.; Durdu B.; Toluk O.; Cakirca M.; YURTSEVER, İSMAİL; KARATOPRAK, CUMALİ; SÜMBÜL, BİLGE; KISKAÇ, MUHARREM; TUNÇ, MUHAMMED; ZORLU, MEHMET; OGUN, HAMZA; DURDU, BÜLENT; TOLUK, ÖZLEM; ÇAKIRCA, MUSTAFAOBJECTIVE: This study aimed to evaluate the SARS-CoV-2 immunoglobulin G (IgG) levels after 6 months of polymerase chain reaction (PCR) negativebut assumed to be COVID-19 positive cases to investigate the relationship between IgG levels and thoracic computed tomography (CT) findings.METHODS: This was a single-center study that included patients whose PCR test results were negative at least three times using nasopharyngealswabs but had clinical findings of COVID-19 and thoracic CT findings compatible with viral pneumonia. Six months after discharge, the IgG antibodieswere analyzed. The cutoff value for negative and positive serology was defined as <1.4 (index S/C) and ≥1.4 (index S/C), respectively. In addition, thepatients were categorized according to their thoracic CT findings as high (typical) and low (atypical). Also, the patients were grouped into classes as<5% lung involvement versus ≥5% lung involvement.RESULTS: The patients’ mean age was 49.78±12.96 years. PCR was negative, but patients with COVID-19 symptoms who had SARS-CoV-2 IgGpositive were 81.9% (n=95). The antibody titer and lung involvement ≥5% were statistically significantly higher in SARS-CoV-2 IgG positive cases(p<0.001 and p=0.021). Age and chest CT findings were the risk factors for lung involvement (OR=1.08, p<0.001 and OR=2.19, p=0.010, respectively).CONCLUSION: This study is valuable because increasing severity (≥5%) of lung involvement appears to be associated with high and persistent IgGantibody titers. In probable cases of COVID-19, even if the PCR test is negative, high IgG titers 6 months after discharge can predict the rate of lungparenchymal involvement.