Person: KILIÇ, ERDEM
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Publication Open Access Serum endocan levels in women with restless legs syndrome.(2015-11-19) CELIK, K; ÇıKRıKÇıOĞLU, MA; HALAC, G; KILIC, ERDEM; AYHAN, S; OZARAS, N; Karatoprak, CUMALİ; YILDIZ, KEMALETTİN; YILDIZ, RS; ZORLU, MEHMET; CAKIRCA, MUSTAFA; KıSKAÇ, MUHARREM; KILIÇ, ERDEM; YILDIZ, KEMALETTİN; ZORLU, MEHMET; KARATOPRAK, CUMALİ; ÇAKIRCA, MUSTAFA; KISKAÇ, MUHARREMBackground: Endocan is a recently introduced marker of endothelial dysfunction. The objective of this study was to compare serum endocan levels in patients with restless legs syndrome (RLS) and control subjects in order to elucidate whether RLS is associated with endothelial dysfunction. Methods: A total of 31 drug naïve female patients with RLS and 31 age- and BMI-matched women were included in the study. Patients with pathological or physiological conditions or with a history of medication use that could potentially influence endothelial functions were excluded, as well as those with alcohol or drug abuse history. The two groups were compared with routine blood tests and serum endocan levels. Results: Patients with RLS had lower serum endocan levels than the controls (P=0.037). There was a negative bivariate correlation between RLS severity score and serum endocan levels (r=-0.406, P=0.023). While white blood cell count was significantly higher in RLS group, 25-hydroxy vitamin D3, vitamin B12, transferrin saturation rate, and HDL-cholesterol were significantly lower. Creatininemia and diastolic blood pressure were also marginally insignificantly lower in RLS group. Due to the presence of differences between two groups in these variables, a linear regression analysis was performed that showed a positive association between endocan and creatininemia (β=0.310, P=0.022), and a negative association between endocan and RLS (β=-0.502, P,0.001). Conclusion: The results of this study seem to suggest that patients with RLS may have better endothelial functions when compared with the general population and that these patients may be better protected against atherosclerosisPublication Open Access Spontaneous and Excellent Healing of Bilateral Brown Tumors in Mandible after Endocrinal Therapy and Subtotal Parathyroidectomy: Case Report with 4-Year Follow-Up(2018-01-01) YÜCESOY, TÜRKER; KILIÇ, ERDEM; DOĞRUEL, FATMA; BAYRAM, FAHRİ; ALKAN, ALPER; AKCAN, Alper Celal; ÖZTÜRK, FİGEN; YÜCESOY, TÜRKER; KILIÇ, ERDEM; ALKAN, ALPERPrimary hyperparathyroidism is an endocrine disorder occurring due to increased secretion of parathormone resulting in a complex of clinical, anatomical, and biochemical alterations. On the other hand, excision of a parathyroid adenoma can normalize the metabolic status. A 24-year-old man was referred to the hospital with bilateral swelling and spontaneous gingival bleeding from posterior of the mandible also with radiolucent well-demarcated lesions bilaterally in the mandibular third molar regions. After consultations, the patient was hospitalized in the endocrinology department where further tests were performed due to highly increased PTH level as 714 pg/ml. Bilateral brown tumors started to regress spontaneously, and no additional surgery was required after subtotal parathyroidectomy was performed. The presented case is the first patient whose bilateral brown tumors in the jaws spontaneously and totally healed after subtotal parathyroidectomy and endocrinal therapy who was strictly followed up for 4 years even though the lesions were associated with impacted third molars.Publication Open Access Reusing dental implants?: an experimental study for detecting the success rates of re-osseointegration(2018-06-19) Ulu, Murat; KILIÇ, ERDEM; SOYLU, EMRAH; KÜRKÇÜ, MEHMET; ALKAN, ALPER; KILIÇ, ERDEM; ALKAN, ALPERBackground: The aim of this study was to histomorphometrically compare the implant-host integration between retrieved implants and new implants. Methods: Jaws in 10 male beagle dogs were divided into four groups, and 36 dental implants were inserted into the jaws. In groups 1 and 2, experimental peri-implantitis was induced within 2 months after implant insertion. In group 1, surface decontamination of implants was achieved using air-flow and citric acid. In group 2, implants were sterilized with autoclave after air-flow and citric acid surface decontamination. Subsequently, these implants were inserted in contralateral jaws of the same dogs and a 3-month period was allowed for osseointegration. In group 3, the implants were removed from human jaws due to peri-implantitis and were inserted into dog jaws following surface cleaning protocol and sterilization with autoclave and a 3-month period was allowed for osseointegration. Group 4 was set as the control group. After the osseointegration period, all the animals were sacrificed. The degree of osseointegration in all groups was evaluated by evaluating the ISQ values and by using histomorphometric measurements. Results: Histological findings showed that bone-implant contact (BIC) percentage (mean ± SD) was 83.39% ± 6.37 in group 1, 79.93% ± 11.83 in group 2, 75.45% ± 9.09 in group 3, and 80.53 ± 5.22 in group 4. Moreover, the resonance frequency analysis (RFA) and ISQ values were similar in all four groups both before and after the implantation. Conclusions: The results of this experimental study indicated that there is no significant difference between new dental implants and re-used dental implants with regards to osseointegration around the implant.Publication Metadata only Vascular Complications in Le Fort I Osteotomy: Incidence, Reasons, and Management of the Intraoperative Hemorrhage(2021-01-01T00:00:00Z) Ulker, Omer; DEMİRBAŞ, AHMET EMİN; KÜTÜK, NÜKHET; KILIÇ, ERDEM; ALKAN, Alper; KÜTÜK, NÜKHET; KILIÇ, ERDEM; ALKAN, ALPERPurpose: The aim of this study was to investigate the incidence, types, and reasons for the intraoperative hemorrhage during Le Fort I osteotomy.Publication Metadata only Does Medication related Osteonecrosis of the Jaw Affect Maxillary Sinus Volume and Mucosal Thickness?(2020-04-01T00:00:00Z) YILMAZ ASAN, CANAY; Akkoyun, Emine Fulya; KILIÇ, Erdem; ALKAN, Alper; AKKOYUN, EMİNE FULYA; KILIÇ, ERDEM; ALKAN, ALPERObjective: Bisphosphonates (BPs) are commonly prescribed drugs because of their antiresorptive effects. However, BPs may cause medication-related osteonecrosis of the jaw (MRONJ). This study aimed to compare the maxillary sinus volumes and mucosal thickening of patients with MRONJ and healthy patients.Publication Open Access Gastrointestinal tract metastasis of mandibular diffuse large B-cell lymphoma(2018-09-01) YÜCESOY, TÜRKER; KILIÇ, ERDEM; Ocak, Hakan; ALKAN, ALPER; DENİZ, KEMAL; YÜCESOY, TÜRKER; KILIÇ, ERDEM; ALKAN, ALPERNot only diffuse large B-cell lymphoma is a malignancy, but also is initially and orally diagnosed in early stages. However, it could be misdiagnosed with other oral pathologies. However yet, early diagnosis is still crucial for the prognosis, morbidity, and mortality in such cases. Additionally, whole-body scanning with positron emission tomography/computed tomography should be performed for diagnosis and treatment process.Publication Metadata only Comparison Of Tilted Implant Concepts With 3D Finite Element Analysis(2018-09-08) KILIÇ, ERDEM; DOGANAY, ÖZGE; DOĞANAY, ÖZGE; KILIÇ, ERDEMPublication Open Access Osseous changes in patients with medication-related osteonecrosis of the jaws(2018-01-01) GÖNEN, ZEYNEP BURÇİN; Asan, Canay Yillmaz; ZARARSIZ, GÖKMEN; KILIÇ, ERDEM; ALKAN, ALPER; KILIÇ, ERDEM; ALKAN, ALPERObjectives: Medication-related osteonecrosis of the jaw (MRONJ) is a severe side effect of antiresorptive agents. The aim of this study was to investigate the osseous changes in patients with MRONJ. Methods: Cone beam CT (CBCT) images of 25 patients with MRONJ and controls were retrospectively evaluated. Buccal, lingual, apical cortical bone thicknesses; buccal, lingual, apical intracortical and cancellous bone density; diameter of mental foramen and incisive canal, and width of mental foramen were measured. Results: Buccal and apical cortical bone thicknesses were increased; however intracortical radiodensity values decreased in the Study Group when compared with the Control Group (p = 0.007, p = 0.001). Narrowing of incisive canal was observed in patients with MRONJ (p = 0.000). Conclusions: Clinician should have awareness about narrowing of incisive canal, apical and buccal cortical bone thickening, decreasing in cancellous bone radiodensity, and the lingual cortex destruction in patients with MRONJ.Publication Metadata only Dentofasiyal Deformiteli Hastalarda Ortognatik Cerrahi Sonrası İskeletsel Relapsın Değerlendirilmesi / Evaluation of Skeletal Relapse After Orthognathic Surgery in Patients with Dentofacial Deformity(2019-04-28T00:00:00Z) YILDIRIM, COŞKUN; DEMİRBAŞ, AHMET EMİN; GÜL AMUK, NİSA; KÜTÜK, NÜKHET; KILIÇ, ERDEM; ALKAN, ALPER; KÜTÜK, NÜKHET; KILIÇ, ERDEM; ALKAN, ALPERPublication Metadata only Removal Of Osteosynthesis Plates After Orthognathic Surgery: A Retrospective Monocentric Study(2019-05-02T00:00:00Z) ÜLKER, ÖMER; DEMİRBAŞ, AHMET EMİN; KÜTÜK, NÜKHET; KILIÇ, ERDEM; ALKAN, ALPER; KÜTÜK, NÜKHET; KILIÇ, ERDEM; ALKAN, ALPER
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