Person: MEYDAN, SEDAT
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Publication Metadata only Protective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in rats(2011-07-01T00:00:00Z) Zararsiz, Ismail; Meydan, SEDAT; Sarsilmaz, Mustafa; Songur, Ahmet; Ozen, Oguz Aslan; Sogut, Sadik; MEYDAN, SEDATThis study aimed to investigate changes in the cerebellum of formaldehyde-exposed rats and the effects of omega-3 fatty acids on these changes. The study involved 21 male Wistar-Albino rats which were divided into three groups. The rats in Group I comprised the control group. The rats in Group II were injected with intraperitoneal 10% formaldehyde every other day. The rats in Group III received omega-3 fatty acids daily while exposed to formaldehyde. At the end of the 14-day experimental period, all rats were killed by decapitation and the cerebellum removed. The activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), xanthine oxidase (XO), and malondialdehyde (MDA) levels were determined in cerebellum specimens by using spectrophotometric methods. In our study, levels of SOD and CAT were significantly decreased, and GSH-Px, XO, MDA levels were significantly increased in rats treated with formaldehyde compared with those of the controls. Whereas, it was seen that there was an increase in SOD and CAT enzyme activities and decrease in MDA, XO, and GSH-Px levels in rats administered to omega-3 fatty acids with exposure of formaldehyde. It was determined that exposure of formaldehyde increased free radicals in cerebellum of rats and this increase was prevented by administration of omega-3 fatty acids.Publication Metadata only Effects of ceftriaxone on ischemia/reperfusion injury in rat brain(2013-03-01T00:00:00Z) Altas, M.; Meydan, SEDAT; Aras, M.; Yilmaz, N.; Ulutas, K. T.; Okuyan, H. M.; Nacar, A.; MEYDAN, SEDATThe aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n = 10), I/R group (n = 10) and I/R-ceftriaxone group (n = 10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p < 0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p < 0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue. (C) 2012 Elsevier Ltd. All rights reserved.Publication Metadata only Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus.(2010-12-01T00:00:00Z) Meydan, SEDAT; KUS, I; TAS, U; OGETURK, M; SANCAKDAR, E; DABAK, DO; ZARARSıZ, I; SARSıLMAZ, M; MEYDAN, SEDATPublication Metadata only Salt and Nitric Oxide Synthase Inhibition-Induced Hypertension: Kidney Dysfunction and Brain Anti-Oxidant Capacity(2010-01-01T00:00:00Z) Oktar, Suleyman; Ilhan, Selcuk; Meydan, SEDAT; Aydin, Mehmet; Yonden, Zafer; Gokce, Ahmet; MEYDAN, SEDATThe specific aim of this study was to examine the effects of salt-loading on kidney function and brain antioxidant capacity. Wistar rats were divided into four groups: Control rats were given normal drinking water and no drug treatment for 2 weeks. LNNA group: rats were given normal drinking water and the nitric oxide (NO) inhibitor NG-nitro-L-arginine (L-NNA), 3 mg/kg/day. LNNA + Salt group: rats were given drinking water containing salt 2% and 3 mg/kg L-NNA. Salt group: rats were given drinking water containing salt 2% and no drug treatment. Basal blood pressure and the levels of serum BUN, creatinine, uric acid, cortisol, electrolyte, serum antioxidant capacity, and oxidative stress were measured. NO, superoxide dismutase (SOD), and catalase (CAT) levels were measured in the hypothalamus, brainstem, and cerebellum. Salt overload increased the blood pressure of the LNNA + Salt group. Salt-loading enhanced BUN, creatinine, sodium retention. High salt produced an increase in uric acid levels and a decrease in cortisol levels in serum. Additionally, the oxidative stress index in serum increased in the LNNA + Salt group. Salt-loading enhanced brain NO levels, but not SOD and CAT activity. L-NNA increased brain SOD activity, but not CAT and NO levels. In conclusion, salt-loading causes hypertension, kidney dysfunction, and enhances oxidative stress in salt-sensitive rats.Publication Metadata only Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity.(2019-05-01) Esrefoglu, MUKADDES; Bayındır, NİHAN; KURBETLI, N; Selek, S; Akbas, Tosunoglu; Meydan, SEDAT; OZTURK, OSMAN; Bulut, HURİ; Meral, I; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; ÖZTÜRK, OSMAN; BAYINDIR, NİHAN; BULUT, HURI; MERAL, İSMAİLPublication Metadata only Effects of lemon essential oil aroma on the learning behaviors of rats.(2010-10-01T00:00:00Z) OGETURK, M; KOSE, E; SARSıLMAZ, M; AKPINAR, B; KUS, I; Meydan, SEDAT; MEYDAN, SEDATPublication Metadata only BENEFICIAL EFFECT OF ERDOSTEINE ON METHOTREXATE-INDUCED TESTICULAR TOXICITY IN MICE(2010-09-01T00:00:00Z) Oktar, S.; Gokce, A.; Aydin, M.; Davarci, M.; Meydan, Sedat; Ozturk, O. H.; Koc, A.; MEYDAN, SEDATPublication Open Access Paraoxonase-1 Phenotype and Its Relationship with Mean Platelet Volume and Oxidative Stress in Coronary Artery Disease(2015-09-01) SELEK, ŞAHBETTİN ; ÖZER, ÖMER FARUK ; GOKTEKİN, Omer ; KOÇYİĞİT, ABDÜRRAHİM; KALINBACOGLU, Ceren; ISLEK, Irem ; ISLEK, Tuğba; ARPACI, Beyza; Erol, Neval; MEYDAN, Sedat; GÜLER, ERAY METİN; SELEK, ŞAHABETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; MEYDAN, SEDAT; GÜLER, ERAY METİNObjective: Paraoxonase-1 (PON1) 192 QR polymorphism is believed to be an important protective factor for coronary artery disease (CAD); oxidative stress plays a key role in the development of atherosclerotic CAD. Mean platelet volume (MPV) is also central to the processes, including pathophysiology of CAD and endothelial dysfunction. Thus, we aimed to determine the PON1 phenotype, MPV, and oxidative stress parameters in patients with angiographically proven CAD and to compare them with those in healthy subjects. Methods: Fifty-five CAD patients were diagnosed according to the angiography results, and 37 healthy subjects were present in this study. Serum paraoxonase and arylesterase activities were spectrophotometrically measured. Phenotype distribution was evaluated by the salt-stimulated paraoxonase activity according to arylesterase activity. Oxidative stress markers were evaluated by measuring serum total oxidant status (TOS) and total antioxidant status (TAS) as well as oxidative stress index. Results: In this study, the ratio of salt-stimulated paraoxonase/ OSI levels (S-PON1/OSI) were lower in the CAD patients and the differences were statistically significant (p<0.05). Therefore, the ratio of salt-stimulated paraoxonase/MPV (S -PON1/MPV) and S- PON1/OSI level were significantly different in the CAD patients as compared with controls group (p<0.01). Conclusion: Our study has suggested that S-PON1/OSI and SPON1/ MPV may play a significant role in CAD. To the best of our knowledge, the present study is the first to study the relationship among PON1 phenotype, MPV, and OSI in CAD patients. Thus, lowering of the oxidative stress and the regulation of MPV strategies may be a promising approach for the treatment of CAD.Publication Open Access Assessment of Auditory Pathways Using Diffusion Tensor Imaging in Patients with Neurofibromatosis Type 1(2018-04-01) MEYDAN, SEDAT; Aydin, Sinem; OTCU, HAFİZE; KİTİŞ, SERKAN; ALKAN, ALPAY; MEYDAN, SEDAT; KİTİŞ, SERKAN; ALKAN, ALPAYThe aim of our study was to determine whether the diffusion properties of the auditory pathways alter between patients with Neurofibromatosis type 1 (NF1) and the healthy subjects. DTI can well demonstrate FA and ADC changes in auditory tracts and it may be a guide to identify the candidates for hearing loss among NF1 children.Publication Open Access Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats(2016-12-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Bayindir, NİHAN; Iraz, Meryem; Ayhan, Siddika; Meydan, SEDAT; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; BAYINDIR, NİHAN; MEYDAN, SEDATObjective: We aimed to investigate the protective effects of curcumin (Cr) against cadmium (Cd) toxicity on the kidneys of both young and aged rats. Methods: Forty-eight young and aged female Spraque–Dawley rats were divided into control, Cd, Cr, and Cd+Cr groups. We investigated kidney damage using a histopathological scoring system and measured total antioxidant status (TAS) and total oxidant status (TOS) and interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels. Results: Kidney tissues of Cd groups showed acute histopathological alterations. Cr improved Cd-induced histopathological changes (p<0.05). The highest mean TAS was recorded in both the Cr groups. The highest mean TOS was recorded only in the aged Cd group. Cr decreased IL-6 levels in both the Cd+Cr groups (p<0.05). PCT levels in the Cd groups were higher than those in the control groups. Significance was detected only between the young Cd and control groups (p<0.05). PCT levels were reduced in both the Cd+Cr groups (p<0.05). CRP levels in the aged Cd group were higher than those in the other groups (p<0.05). Cr reduced CRP levels only in the aged Cd+Cr group (p<0.05). Conclusion: Our results suggest that Cr prevents Cd-induced renal oxidative damage in both young and aged rats.
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