Person: KÜTÜK, NÜKHET
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Publication Metadata only Horizontal Alveolar Distraction of the Mandibular Canine Regions for Implant Placement(2010-05-01T00:00:00Z) Bulut, Emel; Muglali, Mehtap; Celebi, Nükhet; Bekcioglu, Burak; KÜTÜK, NÜKHETHorizontal alveolar augmentation by distraction osteogenesis is an alternative method for reconstructing atrophic alveolar bone. A 65-year-old woman with atrophy of the alveolar rim in the anterior lower jaw, which had inadequate width for implant placement, was presented. Under general anesthesia, vertical and horizontal osteotomies of the buccolabial cortical bone were performed in the canine regions bilaterally. Modified horizontal distraction devices were stabilized to the mandible. Distraction proceeded from the seventh postoperative day at a rate of 0.450 mm twice a day for 6 days. After 3 months, distraction osteogenesis occurred and increased the alveolar width from 2 to 7 mm. Two implants were placed in the distracted areas. Marginal bone resorbtion around the implants was not observed 12 months after implant placement.Publication Metadata only Effects of combination TGF-B1 transfection and platelet rich plasma (PRP) on three-dimension chondrogenic differentiation of rabbit dental pulp-derived mesenchymal stem cells(2019-10-13) Salkin, Hasan; GÖNEN, ZEYNEP BURÇİN; ÖZCAN, SERVET; Lekesizcan, Ayca; BAHAR, DİLEK; KÜTÜK, NÜKHET; ALKAN, ALPER; KÜTÜK, NÜKHET; ALKAN, ALPERAim: The aim of this study was to evaluate the effects of standard culture medium and chondrogenic differentiation medium with PRP on chondrogenic differentiation of rabbit dental pulp-derived mesenchymal stem cells (rabbit DPSCs) that are transfected with transforming growth factor-beta 1 (TGF-B1) gene, based on the hypothesis of TGF- B1 and PRP can be effective on the chondrogenesis of stem cells. Materials and Methods: Rabbit DPSCs were characterized by using flow cytometry, immunofluorescent staining, quantitative Real Time Polymerase Chain Reaction (qRT-PCR) and differentiation tests. For the characterization, CD29, CD44 and CD45 mesenchymal cell markers were used. Rabbit DPSCs were transfected with TGF-B1 gene using electroporation technique in group 1; with PRP 10% in group 2; with chondrogenic medium in group 3; with both chondrogenic medium and PRP in group 4. DPSCs were cultured in medium with 10% inactive PRP in group 5, chondrogenic medium in group 6, chondrogenic medium with PRP 10% in group 7. SOX9, MMP13 and Aggrecan gene expression levels were evaluated in 3, 6, 12. and 24. days by qRT-PCR. Results: The expression levels of SOX9, MMP13 and Aggrecan were higher in group 2, 3 and group 7 in 3th day however in 24th day group 7 and group 2 were found higher. The expression levels changed by time-dependent. The extracellular matrix of the cells in experimental groups were positively stained with safranin O and toluidine blue. Conclusion: The combination in culture medium of TGF-B1 gene transfection and 10% PRP accelerates the chondrogenic differentiation of DPSCs.Publication Metadata only Graft Necrosis Occurred After Iliac Crest Reconstruction After Mandibular Segmental Resection of AmeloblastomaBulut, Emel; Bekcioglu, Burak; Bas, Burcu; KÜTÜK, NÜKHETAmeloblastoma is an uncommon benign odontogenic neoplasm of the maxillofacial region constituting less than 1% of tumors of the oral cavity. Ameloblastomas have been categorized broadly into 3 biologic variants: cystic (unicystic), solid, and peripheral. Unicystic ameloblastoma is a rare and less aggressive variant of ameloblastoma. The aim of this report is to describe a case of cystic ameloblastoma treated with segmental resection and iliac graft reconstruction. The possible reasons of graft failure seen in our patient at the early stage of the healing were also discussed.Publication Metadata only Acute fetal distress following tooth extraction and abscess drainage in a pregnant patient with maxillofacial infection(2013-03-01T00:00:00Z) Celebi, Nükhet; Kutuk, M. S.; TAŞ, Mert; SOYLU, Emrah; Etoz, O. A.; Alkan, A.; KÜTÜK, NÜKHET; ALKAN, ALPEROral infections have been implicated in adverse pregnancy outcomes such as pre-eclampsia, premature delivery and growth retardation. A 28-year-old and 9 months pregnant otherwise healthy woman with a complaint of facial swelling and dental pain was referred to the Department of Oral and Maxillofacial Surgery. Oral examination revealed perimandibular and masticator space infection related to the left mandibular third molar tooth. Eight hours after surgical intervention, fetal distress developed. The patient was immediately taken into surgery and a male baby delivered by Caesarean section. The baby was then admitted to the intensive care unit. On the twelfth day of his admission, the baby was discharged in good health. Severe maxillofacial infection in pregnancy is a medically complicated situation which should be treated by an oral and maxillofacial surgeon in consultation with an obstetric and gynaecology service.Publication Metadata only Vertical ridge augmentation using guided bone regeneration procedure and dental pulp derived mesenchymal stem cells with simultaneous dental implant placement: A histologic study in a sheep model(2019-06-01) Colpak, H. A.; GÖNEN, ZEYNEP BURÇİN; Ozdamar, S.; ALKAN, ALPER; KÜTÜK, NÜKHET; ALKAN, ALPER; KÜTÜK, NÜKHETObjectives: To determine the effects of bone graft and dental pulp derived mesenchymal stem cells (DPMSCs) implantation with simultaneous dental implant placement on osteointegration, newly formed bone and vertical bone height histologically and histomorphometrically in a sheep model.Publication Metadata only Is Ultrasonic Bone Scalpel Useful in Le Fort I Osteotomy?(2020-01-01T00:00:00Z) DEMİRBAŞ, AHMET EMİN; BİLGE, SUHEYB; ÇELEBİ, SELİN; KÜTÜK, Nükhet; ALKAN, Alper; KÜTÜK, NÜKHET; ALKAN, ALPERPurpose: Safety and precision are 2 main goals in research to improve bone cutting in maxillofacial surgery. The aim of this prospective clinical study was to analyze the outcomes using an ultrasonic bone scalpel versus a piezoelectric surgical device and the conventional technique in a Le Fort I osteotomy.Publication Metadata only Evaluation of Vestibular Bone Thickness in Class I Malocclusion Treatment With Corticotomy-Assisted Rapid Orthodontics(2019-11-01T00:00:00Z) GÖNEN, ZEYNEP BURÇİN; ALKAN, Alper; Ekizer, Abdullah; KÜTÜK, Nükhet; Tasdemir, Zekeriya; ALKAN, ALPER; KÜTÜK, NÜKHETBackground: Corticotomy-assisted rapid orthodontics is a widely used method for speeding up conventional orthodontics. This study (i) evaluates the effects of corticotomy alone, corticotomy combined with bone graft, and corticotomy with platelet-rich fibrin (PRF) on vestibular alveolar bone thickness in patients with class I malocclusion; (ii) compares the treatment time with a conventional orthodontic therapy group, and (iii) investigates the periodontal health of patients who have undergone corticotomy-assisted rapid orthodontics.Publication Metadata only Maxillary sinus floor augmentation in patients with maxillary sinus pseudocyst: case report(2011-12-01T00:00:00Z) Celebi, Nükhet; GÖNEN, Zeynep Burçin; Kilic, Erdem; Etoz, Osman; Alkan, Alper; KÜTÜK, NÜKHET; ALKAN, ALPERThe maxillary sinus floor elevation procedure has gained popularity with predictable results, and is a safe, acceptable technique for bone augmentation, providing a base for dental implant treatment. Faint radiopaque lesions at the base of the maxillary sinus are frequent diagnoses on radiographs and must be identified during dental implant planning. Pseudocysts classically appear hemispheric, homogeneously opaque, and well delineated in panoramic and periapical radiographs. The great majority of these lesions are asymptomatic and do not require surgical treatment. In this case report, we present 4 patients who had a maxillary sinus floor elevation procedure using either crestal or lateral approaches in the presence of antral pseudocysts. No complications were encountered during follow-up periods in these patients and all implants are functioning successfully. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:e97-e102)Publication Open Access Comparison of the effects of ozone therapy and photobiomodulation on sciatic nerve injury in rats(2021-11-01T00:00:00Z) GÜNAY CANPOLAT, DİLEK; YÜCESOY, TÜRKER; Colpak, Halis Ali; KAYA, ÖZLEM TUĞÇE; Kolbasi, Bircan; Saraymen, Recep; Karaturk, Habip; KÜTÜK, NÜKHET; CANPOLAT, MEHMET; YÜCESOY, TÜRKER; KÜTÜK, NÜKHETAim: Studies on drugs or alternative therapies are still the main treatment options for PNI. In this study, we aimed to research the effects of PBM and OT on nerve repair in a rat sciatic injury model. Material and Methods: 29 Wistar albino rats were divided into four groups: control (n = 2), sham (n = 9), OT (n = 9) and PBM (n = 9). After 30 days of surgery and treatments, tissue specimens and blood samples were taken for histological and biochemical processing. Histological evaluations were performed at light and electron microscopy levels. Myelin basic protein (MBP) and S100 from the rat serum were analysed also. Results: The OT and PBM groups had a significant increase in regeneration of the sciatic nerve in light microscopic evaluation. In the PBM and OT groups, Schwann cells (SC) around the axons and also axons with a thin myelin sheath were seen, regarded as signs of the myelination process in transmission electron microscopy (TEM) examinations. Discussion: OT and PBM both resulted in a good healing pattern for sciatic nerve injury in the rat model. Therefore, OT and PBM are considered to be simple and reliable alternative treatment methods for PNI.Publication Metadata only Vascular Complications in Le Fort I Osteotomy: Incidence, Reasons, and Management of the Intraoperative Hemorrhage(2021-01-01T00:00:00Z) Ulker, Omer; DEMİRBAŞ, AHMET EMİN; KÜTÜK, NÜKHET; KILIÇ, ERDEM; ALKAN, Alper; KÜTÜK, NÜKHET; KILIÇ, ERDEM; ALKAN, ALPERPurpose: The aim of this study was to investigate the incidence, types, and reasons for the intraoperative hemorrhage during Le Fort I osteotomy.