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KÜTÜK, NÜKHET

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    PublicationOpen Access
    Comparison of the effects of ozone therapy and photobiomodulation on sciatic nerve injury in rats
    (2021-11-01T00:00:00Z) GÜNAY CANPOLAT, DİLEK; YÜCESOY, TÜRKER; Colpak, Halis Ali; KAYA, ÖZLEM TUĞÇE; Kolbasi, Bircan; Saraymen, Recep; Karaturk, Habip; KÜTÜK, NÜKHET; CANPOLAT, MEHMET; YÜCESOY, TÜRKER; KÜTÜK, NÜKHET
    Aim: Studies on drugs or alternative therapies are still the main treatment options for PNI. In this study, we aimed to research the effects of PBM and OT on nerve repair in a rat sciatic injury model. Material and Methods: 29 Wistar albino rats were divided into four groups: control (n = 2), sham (n = 9), OT (n = 9) and PBM (n = 9). After 30 days of surgery and treatments, tissue specimens and blood samples were taken for histological and biochemical processing. Histological evaluations were performed at light and electron microscopy levels. Myelin basic protein (MBP) and S100 from the rat serum were analysed also. Results: The OT and PBM groups had a significant increase in regeneration of the sciatic nerve in light microscopic evaluation. In the PBM and OT groups, Schwann cells (SC) around the axons and also axons with a thin myelin sheath were seen, regarded as signs of the myelination process in transmission electron microscopy (TEM) examinations. Discussion: OT and PBM both resulted in a good healing pattern for sciatic nerve injury in the rat model. Therefore, OT and PBM are considered to be simple and reliable alternative treatment methods for PNI.
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    PublicationOpen Access
    Effect of occlusal splint on interleukin 6, malondialdehyde and 8-hydroxydeoxyguanosine levels in the synovial fluid of patients with temporomandibular disorders
    (2019-12-01T00:00:00Z) Ba, B.; Aksoy, A.; Atmaca, E.; Oz, A. A.; Kaya, O.; Kazan, D.; Yilmaz, E.; KÜTÜK, Nükhet; KÜTÜK, NÜKHET
    The actual role of splint therapy in preventing excessive loading of the temporomandibular joint (TMJ) is still debated. Lower intra-articular pressure levels have been measured in patients wearing occlusal splints, which may also reduce oxidative stress in the articular spaces. The aim of this study was to determine whether splint therapy reduces oxidative stress and inflammation in TMJ internal derangement patients by measuring interleukin 6 (IL-6), malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) levels in the synovial fluid (SF). Twenty-four patients with a temporomandibular disorder (TMD) were included in the study. TMJ SF samples were obtained prior to arthrocentesis. Twelve patients used a 2-mm hard acrylic, maxillary stabilization-type splint for 3 months after arthrocentesis. Twelve patients had no treatment after the SF aspiration. Second SF samples were obtained from all patients at 3 months post arthrocentesis. IL-6, MDA, and 8-OHdG levels in the samples were evaluated. All patients showed a significant symptomatic improvement after treatment (P < 0.005). No statistical correlation was found between the two groups concerning pre-treatment and 3-month SF levels of MDA, 8-OHdG, and IL-6. Although splint therapy was found to be successful in eliminating clinical symptoms of TMD, the results showed no beneficial effect on inflammation and oxidative stress markers in the synovial fluid.
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    PublicationOpen Access
    Comparison of ketamine-propofol and ketamine-dexmedetomidine combinations in children for sedation during tooth extraction
    (2017-05-01) Canpolat, Dilek Gunay; Yildirim, Mustafa Denizhan; Kutuk, Nukhet; DOĞRUEL, FATMA; Ocak, Hakan; AKSU, RECEP; Alkan, ALPER; KÜTÜK, NÜKHET; ALKAN, ALPER
    Objective: To evaluate the efficiency of ketamine-propofol and ketamine-dexmedetomidine drugs in children for sedation during tooth extraction. Methods: The randomised, prospective study was conducted at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, Kayseri, Turkey, from September to November 2013, and comprised children who were due to undergo tooth extraction. Non-invasive blood pressures (systolic and diastolic), peripheral oxygen saturation, heart and respiratory rates and Ramsay Sedation Scores were assessed at baseline, after applying the drugs and then every 5 minutes thereafter. Further, the ketamine-propofol group received 1mg kg-1 of ketamine and propofol, and the ketamine-dexmedetomidine group received 1mg kg-1 of ketamine + 0.5 µg kg1 of dexmedetomidine. Results: Of the 60 participants, there were 30 (50%) in each group. No statistically significant differences were found in terms of heart rate, non-invasive blood pressures at any time and the number of drug repetitions (p>0.05). Nausea-vomiting was statistically higher in the ketamine-dexmedetomidine group (p<0.05). Conclusion: Ketamine-propofol might be a better option due to lower vomiting and nausea episodes and higher surgeon satisfaction levels.
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    PublicationOpen Access
    Are preoperative hematologic parameters predictive of intraoperative bleeding in orthognathic surgery?
    (2021-06-01T00:00:00Z) Canpolat, Dilek Gunay; Colpak, Halls Ali; KÜTÜK, NÜKHET; ALKAN, ALPER; KÜTÜK, NÜKHET; ALKAN, ALPER
    Aim: Orthognathic surgery is performed to correct dentofacial abnormalities and is generally known as a safe procedure with minimal bleeding. The purpose of this study was to evaluate whether the preoperative hematological parameters help predict intraoperative bleeding in orthognathic surgery.