Person: ÖZDEMİR, MEHMET HAKAN
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Publication Metadata only Evaluation of retinal alterations in Parkinson disease and tremor diseases.(2019-11-02T00:00:00Z) TUĞCU, BETÜL; Arif, Melikov; Babacan, Yildiz Gulsen; Gokcal, Elif; Ercan, Rukiye; UYSAL, ÖMER; Ozdemir, Hakan; TUĞCU, BETÜL; BABACAN YILDIZ, GÜLSEN; GÖKÇAL, ELİF; ERCAN, RUKIYE; UYSAL, ÖMER; ÖZDEMİR, MEHMET HAKANOptical coherence tomography (OCT) has been suggested as a method for detection of retinal alterations in neurodegenerative diseases. The usefulness of OCT as a diagnostic tool to differentiate Parkinson-s disease (PD) from other tremor diseases, remains unknown. We aimed to evaluate morphological changes of the retina in patients with PD, essential tremor (ET), essential tremor-Parkinson-s disease (ET-PD) using OCT. Forty-two eyes of 21 patients with PD, 24 eyes of 12 patients with ET, 24 eyes of 12 patients with ET-PD and 44 eyes of 22 age-matched healthy controls were included in the study. All participants underwent detailed neurological and ophthalmological examination. Measurements in all quadrants of macula and retinal nerve fiber layer (RNFL) thickness using OCT were recorded. There was no significant difference among the groups regarding age, sex. The average RNFL thickness was thinner in PD patients than that of ET (p = 0.032). The RNFL thickness in superior quadrant was lower in PD group compared with the ET and control group (p = 0.001, p = 0.016). Significant differences were observed in most of the macular thickness parameters excluding foveolar and foveal thickness (p = 0.865, 0.394). Correlations were found among several OCT parameters and disease duration or severity in all patient groups (p > 0.05). Retinal alterations were found in PD patients compared to ET. However, no significant retinal changes were detected by OCT in patients with ET and ET-PD compared to controls. According to our data, retinal assessments by OCT do not seem to be satisfactory for differentiation of these disorders.Publication Open Access Diffuse Retinal Thickening due to Epiretinal Membrane in a Patient with Idiopathic Parafoveal Telangiectasia(2019-01-01T00:00:00Z) HAMZAYEV, IGBAL; ELBAY, AHMET; EKİNCİ, CANSU; Ozdemir, Hakan; HAMZAYEV, IGBAL; ELBAY, AHMET; EKİNCİ, CANSU; ÖZDEMİR, MEHMET HAKANIdiopathic parafoveal telangiectasia (IPT) is characterized by abnormal dilated or ectatic retinal capillaries with exudation. In many studies macular hole or pseudohole was demonstrated in patients with IPT. However, only one case with the coexistence of IPT and epiretinal membrane (ERNI) formation was reported before. In this study, we presented the retinal alterations of a patient with IPT admitted to our clinic with complaint of blurred vision for two months. A hyperreflective band refers to ERM, diffuse thickening and increased reflectance of inner retinal layers and cystic spaces in the inner nuclear layer of the retina were detected in horizontal optic coherence tomography (OCT) images of left eye. Due to the thickening of the inner retinal layers, foveal depression was lost. There was no full-thickness or partial-thickness retinal tissue defect in any OCT scan.Publication Open Access Autologous Platelet-Rich Fibrin in the Treatment of Refractory Macular Holes(2019-11-06T00:00:00Z) Koytak, Arif; NUHOĞLU, FADİME; BAYRAKTAR, HAVVANUR; Ercan, Rukiye; Ozdemir, Hakan; KOYTAK, İBRAHİM ARİF; NUHOĞLU, FADİME; BAYRAKTAR, HAVVANUR; ERCAN, RUKIYE; ÖZDEMİR, MEHMET HAKANPurpose. To describe a novel method for the treatment of refractory macular holes. Methods. Two case reports on the use of autologous platelet rich fibrin (PRF), followed by sulfur hexafluoride gas tamponade to facilitate closure of refractory macular holes. Results. Macular holes were succesfully closed within a week in both cases. Best corrected Snellen visual acuities improved from counting fingers to 0.16 in the first case, and from 0.05 to 0.2 in the second case. No complication occurred during or a er the procedures. Conclusion. e use of autologous PRF seems to be a safe and effective alternative method for the treatment of refractory macular holes. Further experience and studies are required to assess the value of autologous PRF in the management of challenging macular hole cases of different etiologies. To the best of our knowledge, this is the first use of autologous PRF in the treatment of macular holes.Publication Metadata only Regional analysis of segmented-macular structure in patients with myopic anisometropia(2021-06-01T00:00:00Z) KIRIK, FURKAN; EKİNCİ, CANSU; AKBULUT, ERSİN; BAYRAKTAR, HAVVANUR; Ozdemir, Hakan; KIRIK, FURKAN; EKİNCİ, CANSU; AKBULUT, ERSİN; BAYRAKTAR, HAVVANUR; ÖZDEMİR, MEHMET HAKANPurpose To compare intraretinal layers between the eyes in patients with myopic anisometropia, and evaluate the relationship between the layers with spherical equivalent (SE) and axial length (AL). Methods In this retrospective study, the more myopic (MM) and fellow (F) eyes of 41 patients with myopic anisometropia, and 38 emmetropic (+/- 0.50 diopter) control (C) eyes were inclueded. Intraretinal layer segmentation was performed by optical coherence tomography. Global volumes of retinal layers and their thicknesses in nine macular regions were compared. Correlation analysis was used to determine the relationship with SE and AL in each layer. Results Total retinal, ganglion cell (GCL), inner nuclear (INL), and outer plexiform (OPL) layer volumes in MM eyes were less than in C eyes, while INL and OPL were less than in F eyes. There was no difference in the fovea, except for the retinal pigment epithelium. In MM eyes, only INL and OPL were thin in at least one perifoveal and parafoveal quadrant compared to F eyes. Only INL and OPL thicknesses were significantly correlated with both SE and AL in all perifoveal quadrants. In contrast to the thinning found in MM eyes, the only layer in which thickening was detected to compare to C eye was nerve fiber layer (NFL), which correlated positively with SE and negatively with AL. Conclusion While the fovea is less affected by myopia, thinning becomes remarkable in the perifoveal quadrants. Despite thinning in many layers, especially INL and OPL, NFL thickening may be seen due to myopia.Publication Open Access Cilioretinal artery occlusion with paracentral acute middle maculopathy associated with COVID-19(2021-07-01T00:00:00Z) Bayram, Nurettin; Ozdemir, Hakan; Ozsaygili, Cemal; ÖZDEMİR, MEHMET HAKANThe purpose of the study is to describe cilioretinal artery (CILRA) occlusion that is presumed to be associated with COVID-19 without severe respiratory distress and inform ophthalmologists of unusual ocular presentations of COVID-19. Here, we present the first case of a patient with isolated CILRA occlusion and paracentral acute middle maculopathy (PAMM) after recently polymerase chain reaction-proven COVID-19. A 26-year-old female patient presented with a visual field defect in her left eye for 2 days and decreased vision compared to her right eye. It was learned that the patient had a laboratory-proven COVID-19 infection with mild respiratory symptoms that did not require hospitalization 2 weeks ago. Fundus examination revealed retinal edema in the left eye area supplied by the CILRA. Spectral-domain optical coherence tomography revealed a prominent hyperreflective band at the inner nuclear layer level. These findings led us to the diagnosis of isolated CILRA occlusion and PAMM associated with recent COVID-19. CILRA occlusion and PAMM could be associated with the inflammatory and procoagulant condition caused by the SARS-CoV-2 infection.Publication Metadata only Expert recommendations for the management of diabetic macular edema with intravitreal dexamethasone implant: A Turkish Delphi study(2022-08-01T00:00:00Z) Batioglu, Figen; YANIK ODABAŞ, ÖZGE; SAATCİ, ALİ OSMAN; Eldem, Bora; AKKIN, CEZMİ; AFRASHİ, FİLİZ; Ozdemir, Hakan; MENTEŞ, JALE; Gungor, Kivanc; KARABAŞ, VEYSEL LEVENT; Karacorlu, Murat; DEMİRCAN, AYŞE NİHAL; Kocak, Nilufer; Kir, Nur; Unlu, Nurten; Avci, Remzi; Arvas, Sema; Dundar, Sema Oruc; KADAYIFÇILAR, SİBEL; KAYNAK, SÜLEYMAN; ÖZDEK, ŞENGÜL; Ovali, Tunc; ÖZDEMİR, MEHMET HAKANPurpose To provide consensus on the clinical use of intravitreal dexamethasone (DEX) implant for the treatment of diabetic macular edema (DME) in Turkey. Methods A panel of 22 retina experts prepared 77 statements of recommendation, and 80 retinal specialists practicing in Turkey were chosen to vote either in support or against each one. A Delphi-based method was used through which the ophthalmologists were able to view all of the results anonymously after two rounds and modify their subsequent answers. The survey was conducted via a mini website, and statements without consensus were resent to the specialists with the latest vote results a week later. Results A total of 72 ophthalmologists answered the first and second round questions. After the first stage, consensus was achieved on 55 of the statements, leaving 22 without agreement. After the second stage, consensus was reached on 11 of the remaining statements. Strong consensus was achieved on statements regarding the etiopathogenesis of DME and the first-line indications and safety of the DEX implant procedure. The panel recommended the use of DEX implant for patients with an arterial thromboembolic event in the last three months and also agreed that pro re nata DEX implant treatment not only provides better outcomes for DME patients but also reduces the treatment burden for those who could not receive an adequate number of anti-vascular endothelial growth factor (VEGF) injections. Conclusion This study provides clinical consensus and recommendations about the use of DEX implant in the clinical practice of DME management in Turkey.Publication Metadata only Effects of platelet rich fibrin alone used with rigid titanium barrier(2013-05-01T00:00:00Z) Ozdemir, Hakan; Ezirganli, Seref; KARA, MUHAMMED İSA; Mihmanli, Ahmet; BARIŞ, EMRE; ÖZDEMİR, MEHMET HAKANObjective: Platelet-rich fibrin (PRF) is a platelet and leukocyte rich and platelet preparation that concentrates various growth factors and therefore has the potential to be used as regenerative treatment. The aim of study was to assess the effects of platelet rich fibrin (PRF) on bone augmentation when used in conjunction with titanium barrier a rabbit calvaria model.