Person: TAKMAZ, TAHA
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Publication Metadata only Administration of rectal cytotec versus rectal buscopan before hysteroscopy(2020-06-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; AYDIN, SERDAR; ATEŞ, SEDA; TAKMAZ, TAHA; Comba, Cihan; GÖKMEN KARASU, AYŞE FİLİZ; AYDIN, SERDAR; ATEŞ, SEDA; TAKMAZ, TAHAIntroduction:Our objective was to compare the effect of rectal misoprostol (Cytotec) versus rectal hyoscine-n-butyl bromide (Buscopan) on patients undergoing hysteroscopy. We hypothesised that HBB may have a role in cervical priming. Material and methods:This trial was conducted at Bezmialem Vakif University Hospital. Women of reproductive age between 18-50 years who were scheduled for operative hysteroscopy indicated by type 1 submucous myoma or endometrial polyps were recruited for the study. Ninety patients were divided randomly into three groups. Group 1 received placebo treatment. Group 2 received rectal 200 mcg misoprostol and Group 3 received rectal 20 mg hyoscine-n-butyl bromide two hours before the procedure. Procedures were performed using a bipolar 26 F (9 mm) continuous-flow rigid resectoscope with a 30 degrees lens. The outcome measures included cervical dilation width and time, ease of cervical dilation, procedure time and operative complications. Postoperative self-rated pain was assessed one hour after the procedure. Results:Thirteen patients (43. 3%) in the placebo treatment group, 11 patients (36.7%) in the misoprostol group and four patients (13.3%) in the hyoscine-n-butyl bromide group needed analgesics postoperatively (p = .02). The mean duration of cervical dilation time was longest in Group 1 and shortest in Group 3, however this difference did not reach statistical significance (p=.11). There was no difference with regard to other studied parameters. Summary:HBB reduced the need for pain medication compared to placebo. Larger studies are needed to further investigate the role of HBB in facilitating pre-operative cervical priming.Publication Metadata only The Role of the Urine Dipstick Test in the Detection of Abnormal Proteinuria Using Different Cut-off Levels in Hypertensive Pregnancies Hipertansif Gebeliklerde Farklı Kesim Değerleri Kullanılarak Anormal Proteinüri Saptanmasında Spot İdrar Protein Ölçümünün Rolü(2022-01-01) Takmaz T.; Gorchiyeva I.; Arici Halici B. N.; TOPRAK A.; ÇETİN Ç.; KÜTÜK M. S.; TAKMAZ, TAHA; ARICI HALICI, BELFİN NUR; TOPRAK, ALİ; ÇETİN, ÇAĞLAR; KÜTÜK, MEHMET SERDAR© 2022, Duzce University Medical School. All rights reserved.Aim: The aim of this study was to determine the diagnostic accuracy of different urine dipstick protein threshold levels in predicting the presence of abnormal proteinuria in pregnant women with hypertension. Material and Methods: A total of 326 singleton pregnant women who underwent 501 urine protein tests and who had suspected preeclampsia were included in this retrospective study. Patient data was taken including medical and obstetric history. The results of dipstick urinalysis and concurrent 24-hour urine protein excretion measurements were compared to determine the accuracy of urinalysis. Results: A dipstick result of 1+ was found to be the best cut-off to predict 500 mg of protein excretion per day, with sensitivity and specificity of 62.09% and 88.97%, respectively. A 2+ proteinuria dipstick cut-off had high specificity and positive predictive value (PPV) (99.05% and 98.84%, respectively) for the prediction of 300 mg of protein excretion per day; this cut-off had low sensitivity (21.46%). A cut-off of 1+ also provided satisfactory specificity and PPV (91.43% and 94.48%, respectively) for the detection of 300 mg of protein excretion per day, but sensitivity was compromised (38.89%). Among 301 patients with negative dipstick results, 212 had a 24-hour urine protein extraction greater than 300 mg, with a false negative rate of 70.43%. Conclusion: The results suggest that the urine protein dipstick measurement has limited quantitative ability for the prediction of abnormal proteinuria. Additionally, the use of 500 mg 24-hours protein excretion as a cut-off value for abnormal proteinuria may provide useful data.Publication Metadata only Evaluation of chronotype and sleep quality in infertile population and comparison with fertile population: a cross-sectional study(2023-12-01) Özçelik C.; VARLI B.; Gökçe A.; Takmaz T.; ÇETİN Ç.; ÖZCAN P.; TAKMAZ, TAHA; ÇETİN, ÇAĞLAR; ÖZCAN, PINARPURPOSE: Infertility is a stressful condition for couples and can affect patients\" circadian rhythm and sleep quality. The goal of this study is to assess differences in chronotype and sleep quality between infertile and fertile people. METHODS: A cross-sectional study was conducted. The infertile patient population consisted study group. Primiparous patients without any known gynecological disease who presented for routine cervical cancer screening follow-up were included in the control group. The Turkish version of the Morningness-Eveningness Questionnaire (MEQ) and Pittsburg Sleep Quality Index (PSQI) scores were evaluated between groups. RESULTS: A total of 227 patients were assessed. There were 110 patients in the study (infertile) group and 117 patients in the control (fertile) group. The evening chronotype proportion (23.6 vs. 0.9%, p < 0.001) was higher in the infertile group. The median of MEQ score was significantly higher in the fertile patients (50, IQR = 43 - 55 vs. 56, IQR = 51 - 59; p < 0.001), and the median of PSQI score was significantly higher in the infertile patients (5, IQR = 4 - 6, vs. 4, IQR = 3 - 5; p < 0.001). CONCLUSIONS: In this study, we found significantly worse sleep quality, and more evening chronotype in the patients with infertility.Publication Open Access Chronotype anc Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome(2021-01-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; Sahbaz, Cigdem Dilek; Dogu, Zeynep Filiz Eren; TAKMAZ, TAHA; ÇALI, HALİME; Tanoglu, Basak; GÖKMEN KARASU, AYŞE FİLİZ; ŞAHBAZ, ÇIĞDEM DILEK; TAKMAZ, TAHA; ÇALI, HALİMEAim: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women during the reproductive ages. The purpose of this study was to investigate the chronotype and sleep quality of PCOS patients.Publication Metadata only Prenatal Sonographic Detection of Monochorionic Twins with Bipartite Placenta(2020-02-10T04:00:00Z) KÜTÜK, MEHMET SERDAR; TAKMAZ, TAHA; Bayram, Arslan; Ozturk, Sule; KÜTÜK, MEHMET SERDAR; TAKMAZ, TAHABackground: Determination of placentation and amnionicity is important for antenatal and intrapartum management in twin gestations. We present an typical monozygotic twin placenta and underscore the sonographic features and diagnostic pitfalls that may interfere with antenatal diagnosis. Case report: A 35-year-old G4P2 with a spontaneous pregnancy applied for routine second trimester anomaly screening. Upon prenatal ultrasonography at 20 weeks, an anatomically normal, same sex twin pregnancy was detected. A thin dividing membrane and a T-sign suggestive of a monochorionic diamniotic pregnancy were visualized. Antenatal follow-up was uneventful. Cesarean delivery was performed at 37 week. Postpartum examination revealed two distinct placental discs connected with each other through membranes. Microscopic examination of the membranes supported monochorionicity. Short Tandem Repeat Profile Analysis revealed identical pattern and confirmed monozygosity. Conclusion: Two separate placentas with a T-sign in same-sex twins should raise the suspicion of monozygosity, and should be followed accordingly.Publication Open Access Vaginal assisted laparoscopic sacrocervicopexy with anterior colpotomy (VALSAC): technique and mean 20 months outcomes(2020-12-01T00:00:00Z) ŞEVKET, OSMAN; TAKMAZ, TAHA; Sevket, A. C.; TOPRAK, ALİ; ÖZCAN, PINAR; ŞEVKET, OSMAN; TAKMAZ, TAHA; TOPRAK, ALİ; ÖZCAN, PINARThe main purpose of our study is to evaluate the efficacy and safety of vaginal assisted laparoscopic sacrocervicopexy with anterior colpotomy (VALSAC) for apical pelvic organ prolapse. We retrospectively reviewed the results of twenty-three women with stage III and IV prolapse treated with VALSAC between April 2017 and June 2019. With a mean follow-up of 20 months, apical pelvic organ prolapse was cured in 95.7 % of patients. There was no complication in terms of mesh exposure, persistent pain, hematoma, infection. The mean pre- and post-operative POP-Q scores were, for the Aa point, 1.61 +/- 1.82 cm and -1.96 +/- 0.87 cm (p < 0.01), for the C point, 2.87 +/- 1.6 cm and -5.26 +/- 1.86 cm (p < 0.01) for the Ap point, -1.43 +/- 0.89 cm and -2.09 +/- 0.59 cm (p < 0.01). VALSAC is a promising minimally invasive technique for pelvic floor reconstruction that appears to provide good outcomes. Content: The main purpose of our study is to evaluate the efficacy and safety of vaginal assisted laparoscopic sacrocervicopexy with anterior colpotomy (VALSAC) for apical pelvic organ prolapse.Publication Open Access The protective effect of platelet-rich plasma administrated on ovarian function in female rats with Cy-induced ovarian damage(2020-04-01T00:00:00Z) ÖZCAN, Pınar; TAKMAZ, TAHA; Tok, Olgu Enis; Islek, Sevde; Yigit, Esra Nur; Ficicioglu, Cem; ÖZCAN, PINAR; TAKMAZ, TAHAPurpose We evaluated the protective effect of PRP on ovarian function in female rats with cyclophosphamide (Cy)-induced ovarian damage. Methods Thirty-two adult female Sprague-Dawley rats were randomly divided into four groups. Group 1 (control-sodium chloride 0.9%; 1 mL/kg, single-dose ip injection), group 2 (Cy); 75 mg/kg, single-dose ip injection and sodium chloride 0.9% (1 mL/kg, single-dose ip injection), group 3 Cy plus PRP, Cy (75 mg/kg, single-dose and PRP (200 mu l, single-dose) ip injection), group 4 (PRP, 200 mu l, single-dose ip injection). Primordial, antral, and atretic follicle counts; serum anti-Mullerian hormone (AMH) levels; AMH-positive granulosa cells; and gene expression analysis of Ddx4 were assessed. Results Serum AMH levels were significantly lower in group 2 compared to groups 1, 3, and 4 (p < 0.01, p < 0.01, and p = 0.04, respectively). A significant difference was found in the primordial, primary, secondary, antral, and atretic follicle counts between all groups (p < 0.01). There was a statistically significant difference in AMH-positive staining primary, secondary, and antral follicles count between the groups (p < 0.01). There was a statistically significant difference in primary, secondary, and antral AMH positive staining follicle intensity score between the groups (p < 0.01). Ddx4 expression in group 4 was highest compared to other groups. Conclusion Our study may provide evidence that PRP could protect ovarian function against ovarian damage induced by Cy. It could lead to improved primordial, primary, secondary, and antral follicle numbers.Publication Metadata only Fundal pressure in the second stage of labor (Kristeller maneuver) and levator aniavulsion(2020-11-01T00:00:00Z) TAKMAZ, TAHA; Aydin, Serdar; GÖKMEN KARASU, AYŞE FİLİZ; TAKMAZ, TAHA; GÖKMEN KARASU, AYŞE FİLİZPublication Metadata only The usual suspect: cross-sectional study of fundal pressure at second stage of delivery and the association with pelvic floor damage(2020-09-01T00:00:00Z) TAKMAZ, TAHA; AYDIN, SERDAR; Gorchiyeva, Irana; GÖKMEN KARASU, AYŞE FİLİZ; TAKMAZ, TAHA; AYDIN, SERDAR; GÖKMEN KARASU, AYŞE FİLİZIntroduction and hypothesis Uterine fundal pressure is applied to accelerate birth by increasing the expulsive force of the uterus in the second stage of delivery. The aim of the study was to evaluate the effect of using uterine fundal pressure during the second stage of delivery on the rate of pelvic floor damage among primiparous women using three-dimensional transperineal ultrasonography. Methods The women were divided into two groups: the fundal pressure group included women where the fundal pressure maneuver was applied (n = 39); the control group included women who delivered spontaneously without fundal pressure (n = 47). 3D-TPU was performed within 48 h of delivery, and LAM biometry, LAM defect and loss of tenting were determined. Results Anteroposterior hiatal dimensions on resting, maximal Valsalva and maximal PFMC were found to be higher in the fundal pressure group (p < 0.0001,p = 0.008,p = 0.007, respectively). The mean hiatal area at rest was larger in the fundal pressure group than in the control group (p = 0.04). The rate of LAM defect was significantly higher in the fundal pressure group (p = 0.001). The rate of loss of tenting was significantly higher in the fundal pressure group (p < 0.0001). According to multivariate regression models, the fundal pressure was the only independent factor associated with LAM defect (OR = 5.63; 95% CI = 12.01-15.74) and loss of tenting (OR = 8.74; 95% CI = 2.89-26.43). Conclusions Fundal pressure during the second stage of delivery is associated with a higher risk of LAM defect and loss of anterior vaginal wall support.Publication Metadata only Are chronotype and subjective sleep quality associated with preeclampsia and preterm birth?(2020-02-20T04:00:00Z) TAKMAZ, TAHA; Unal, Busra; ÖZCAN, Pınar; ARICI HALICI, BELFİN NUR; Gorchiyeva, Irana; GÖKMEN KARASU, AYŞE FİLİZ; Sahbaz, Cigdem; TAKMAZ, TAHA; ÖZCAN, PINAR; ARICI HALICI, BELFİN NUR; GÖKMEN KARASU, AYŞE FİLİZ; ŞAHBAZ, ÇIĞDEM DILEKThe physiological and physical changes in pregnancy affect the sleep-wake cycle. Limited data exist to evaluate the effect of sleep quality and chronotype during pregnancy on adverse pregnancy outcomes. It is hypothesized that there could be a tendency for the evening chronotype and sleep disturbances to lead to the development of preeclampsia and preterm birth. A total of 313 pregnant women were included. Women were divided into three groups: Group A (control - problem-free), Group B (preeclampsia) and Group C (preterm birth). There were significant differences in the mean PSQI score between the groups (A vs C and A vs B) (p < 0.01). Women in the preterm and the preeclampsia groups reported significantly worse sleep quality. There was a significant difference in the mean MEQ scores between groups (A vs C and A vs B) (p < 0.01). The ratio of the evening-types was significantly higher for the preterm and preeclampsia groups (p < 0.01). Multivariate logistic regression analysis revealed that there is a negative association between preeclampsia/preterm birth and MEQ score, positive association between preeclampsia/preterm birth and PSQI score. Chronotype and sleep quality measurements could provide a simple and feasible way in the prediction of adverse pregnancy outcomes.