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ÇEŞME, DİLEK HACER

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DİLEK HACER
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ÇEŞME
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2015 - 201912020 - 202320
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    Is quantitative diffusion-weighted MRI a valuable technique for the detection of changes in kidneys after extracorporeal shock wave lithotripsy?
    (2015-01-01T00:00:00Z) Hocaoglu, Elif; Inci, Ercan; Aydin, Sibel; Cesme, DİLEK HACER; Kalfazade, Nadir; ÇEŞME, DİLEK HACER
    Objective: The aim of this study was to evaluate the capability and the reliability of diffusion-weighted imaging (DWI) in the changes of kidneys occurring after extracorporeal shock wave lithotripsy (ESWL) treatment for renal stones.
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    Antero-posterior axis of the tibia is a better landmark for tibial component rotation in Oxford medial unicompartmental knee arthroplasty.
    (2022-09-20T00:00:00Z) Aliyev, O; Ağır, M; Aghazada, A; Çeşme, DH; Kara, D; Toprak, ALİ; Tuncay, İ; Yıldız, F; ÇEŞME, DİLEK HACER; TOPRAK, ALİ
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    PublicationOpen Access
    Effectiveness of Diffusion Tensor Imaging in the Microstructural Evaluation of Corpus Callosum and Brain Parenchyma in Children with Neurofibromatosis Type I
    (2021-04-01T00:00:00Z) ÇEŞME, DİLEK HACER; ÇEŞME, DİLEK HACER
    Objective: To compare tractional anisotropy (FA) and mean diffusivity (MD) values obtained from corpus callosum (CC), basal ganglion, thalamus, frontal and parietal white matter in NF1 patients compared to the control group and to investigate the correlation with CC volume. Methods: Thirty three cases diagnosed with NF1 and 21 healthy control groups were included in the study. CC volume was measured in both groups. Using tensor imaging (DTI), MD and FA values were calculated from CC genu and splenium, globus pallidum, caudate nucleus, putamen, thalamus, parietal and frontal white matter. Results: CC volume increased significantly in cases with NF1. There was a significant difference in MD and FA values obtained from CC genu and splenium compared to the control group. MD values obtained from frontal and parietal white matter, globus pallidum, putamen, thalamus and caudate nucleus were significantly higher than the control group. FA values decreased in caudate nucleus and putamen while FA values in globus pallidum were higher than control group. There was a negative correlation between CC volume and MD values obtained from KK splenium, putamen, thalamus and caudate nucleus Conclusion: Increased MD in areas of involvement in NF1 cases can be explained by impaired myelination and demyelination. Heterogeneity in FA values suggests that it is caused by microstructural differences resulting from the breakdown of myelin sheaths or axonal disruption in different locations of the brain. In cases with NF1, DTI findings will help us to understand the occurrence of the disease and the physiopathology of clinical findings in more detail.
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    PublicationOpen Access
    Diagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases
    (2021-12-22T00:00:00Z) Yilmaz, TEMEL FATİH; Gultekin, Mehmet Ali; Turk, Hacı Mehmet; Cesme, Dilek Hacer; Besiroglu, Mehmet; Simsek, Melih; Toprak, Huseyin; Alkan, ALPAY; YILMAZ, TEMEL FATİH; TÜRK, HACI MEHMET; ÇEŞME, DİLEK HACER; ŞİMŞEK, MELİH; ALKAN, ALPAY; TOPRAK, HÜSEYİN
    Background: We aimed to investigate whether there is a difference between intrahepatic cholangiocarcinoma (IHCC) and liver metastases of gastrointestinal system (GIS) adenocarcinoma in terms of apparent diffusion coefficient (ADC) values. Patients and methods: From January 2018 to January 2020, we retrospectively examined 64 consecutive patients with liver metastases due to gastrointestinal system adenocarcinomas and 13 consecutive IHCC in our hospital's medical records. After exclusions, fifty-three patients with 53 liver metastases and 10 IHCC were included in our study. We divided the patients into two groups as IHCC and liver metastases of GIS adenocarcinoma. For mean apparent diffusion coefficient (ADCmean) values, the region of interests (ROI) was placed in solid portions of the lesions. ADCmean values of groups were compared. Results: The mean age of IHCC group was 62.50 ± 13.49 and mean age of metastases group was 61.15 ± 9.18. ADCmean values were significantly higher in the IHCC group compared to the metastatic group (p < 0.001). ROC curves method showed high diagnostic accuracy (AUC = 0.879) with cut-off value of < 1178 x 10-6 mm2/s for ADCmean (Sensitivity = 90.57, Specificity = 70.0, positive predictive value [PPV] = 94.1, negative predictive value [NPV] = 58.3) in differentiating adenocarcinoma metastases from IHCC. Conclusions: The present study results suggest that ADC values have a potential role for differentiation between IHCC and GIS adenocarcinoma liver metastases which may be valuable for patient management.
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    PublicationOpen Access
    Diffusion Tensor Imaging Can Discriminate the Primary Cell Type of Intracranial Metastases for Patients with Lung Cancer.
    (2021-03-04T00:00:00Z) Bilgin, Sabriye Sennur; Gultekin, Mehmet Ali; Yurtsever, Ismail; Yilmaz, Temel Fatih; Cesme, Dilek Hacer; Bilgin, Melike; Topcu, Atakan; Besiroglu, Mehmet; Turk, Haci Mehmet; Alkan, ALPAY; Bilgin, Mehmet; GÜLTEKİN, MEHMET ALİ; YURTSEVER, İSMAİL; YILMAZ, TEMEL FATİH; ÇEŞME, DİLEK HACER; TÜRK, HACI MEHMET; ALKAN, ALPAY; BİLGİN, MEHMET
    Purpose: Histopathological differentiation of primary lung cancer is clinically important. We aimed to investigate whether diffusion tensor imaging (DTI) parameters of metastatic brain lesions could predict the histopathological types of the primary lung cancer. Methods: In total, 53 patients with 98 solid metastatic brain lesions of lung cancer were included. Lung tumors were subgrouped as non-small cell carcinoma (NSCLC) (n = 34) and small cell carcinoma (SCLC) (n = 19). Apparent diffusion coefficient (ADC) and Fractional anisotropy (FA) values were calculated from solid enhanced part of the brain metastases. The association between FA and ADC values and histopathological subtype of the primary tumor was investigated. Results: The mean ADC and FA values obtained from the solid part of the brain metastases of SCLC were significantly lower than the NSCLC metastases (P < 0.001 and P = 0.003, respectively). ROC curve analysis showed diagnostic performance for mean ADC values (AUC=0.889, P = < 0.001) and FA values (AUC = 0.677, P = 0.002). Cut-off value of > 0.909 × 10-3 mm2/s for mean ADC (Sensitivity = 80.3, Specificity = 83.8, PPV = 89.1, NPV = 72.1) and > 0.139 for FA values (Sensitivity = 80.3, Specificity = 54.1, PPV = 74.2, NPV= 62.5) revealed in differentiating NSCLC from NSCLC. Conclusion: DTI parameters of brain metastasis can discriminate SCLC and NSCLC. ADC and FA values of metastatic brain lesions due to the lung cancer may be an important tool to differentiate histopathological subgroups. DTI may guide clinicians for the management of intracranial metastatic lesions of lung cancer.
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    A Case of Neurosarcoidosis Mimicking Brain Tumor
    (2021-01-01T00:00:00Z) SARI, LÜTFULLAH; PEKER, ABDUSSELİM ADİL; ÇEŞME, DİLEK HACER; ALKAN, ALPAY; SARI, LÜTFULLAH; PEKER, ABDUSSELİM ADİL; ÇEŞME, DİLEK HACER; ALKAN, ALPAY
    Background: Neurosarcoidosis manifests symptomatically in 5% of patients with sarcoidosis and diagnosis can be challenging if not clinically suspected. Cerebral mass-like presentation of neurosarcoidosis rarely reported in the literature. We presented a woman with neurosarcoidosis who had a cerebral mass-like lesion which completely disappeared after medical treatment.
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    PublicationOpen Access
    Evaluation of Optical Radiation from Visual Pathways with Diffusion Tensor Imaging in Patients with Neurofibromatosis Type 1
    (2021-10-01T00:00:00Z) ÇEŞME, DİLEK HACER; ÇEŞME, DİLEK HACER
    Objective: It was investigated whether patients with neurofibromatosis type 1 (NF1) with and without optic glioma (OG) differed from the healthy control group in terms of diffusion tensor imaging (DTI) parameters obtained from optic radiation. Methods: Eighty three patients and 36 healthy controls followed with the diagnosis of NF1 were included in the study. Routine MRI and DTI were applied to all subjects. Fractional anisotropy (FA), mean diffusity (MD), radial diffusity (RD) and axial diffusity (AD) values were calculated by placing ROI on the right and left optic radiation on colored FA maps. Patients with OG detected by conventional magnetic resonance imaging (n=19) were classified as group 1, patients with NF1 without OG (n=64) were classified as group 2 and they were compared with the healthy control group in terms of DTI parameters. Results: The right and left optic radiation FA values of the patients in group 1 and group 2 were significantly different when compared with the healthy control group. Optical radiation FA values were significantly lower than healthy control group. MD values in group 1 patients with OG were significantly higher than healthy control group. Optic radiation RD values were significantly higher in group 1 and group 2 compared with healthy control group. Conclusion: There appears to be microstructural damage in optic radiation in patients with NF1 with or without OG. The idea that changes in FA values detected in optic radiation in visual pathways in patients with NF1 can be predicted in the early period of visual impairment is promising in terms of treatment planning and management.
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    Importance of thalamo-striatal pathway associated with neurocognitive dysfunctions in children with Neurofibromatosis type 1; Diffusion Tensor Imaging Findings
    (2021-03-01T00:00:00Z) Aydın, Sinem; İşcan, Akın; Çeşme, Dilek Hacer; Alkan, Alpay; Gultekin, Mehmet Ali; Peker, Abdusselim; ÇEŞME, DİLEK HACER; ALKAN, ALPAY
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    PublicationOpen Access
    Evaluation of toxic effects of chemotherapy in lung malignancies on cerebral white matter using diffusion tensor imaging
    (2022-05-04T00:00:00Z) Aydin, Sinem; Demir, Tarik; Turk, Haci Mehmet; Cesme, DİLEK HACER; Aliyev, Altay; Ali Gultekin, Mehmet; Fatih Yilmaz, Temel; Alkan, ALPAY; TÜRK, HACI MEHMET; ÇEŞME, DİLEK HACER; ALKAN, ALPAY
    Background: Non-small cell lung cancer (NSCLC) is a leading cause of morbidity and mortality. Carboplatin and cisplatin based regimens are used in the treatment of NSCLC. The aim of the study was to find out whether there is a difference in white matter (WM) changes between two platinum-based chemotherapy agents using diffusion tensor imaging (DTI). Patients and methods: 25 patients who received chemotherapy for NSCLC and 27 age-matched healthy controls were enrolled in the study. Fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD) and radial diffusivity (RD) values of the study population were measured from 11 regions of interest in pre-chemotherapy and post-chemotherapy MRI data. Results: Cisplatin group showed a significant decrease in the FA of the inferior longitudinal fasciculus (P = 0.028). Carboplatin group showed a significant FA decrease and RD increase in the forceps minor (P = 0.022 and P = 0.011, respectively), and a significant reduction in AD and increase in MD in frontal white matter (WM) (P = 0.008 and P = 0.029, respectively). In comparison of post chemotherapy DTI values of the two groups, carboplatin group showed lower FA, and higher MD and RD values than cisplatin group in parieto-occipital WM (P = 0.034, P = 0.034, P = 0.029, respectively). Conclusions: The findings of the study suggest that subtle effects of chemotherapy detectable with DTI may emerge after the treatment. In addition, carboplatin regimen may have more impact on WM than cisplatin regimen.
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    PublicationOpen Access
    Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma
    (2021-01-01T00:00:00Z) Cesme, Dilek Hacer; Alkan, Alpay; Gultekin, Mehmet Ali; Sari, Lutfullah; Alkan, Gokberk; Seyithanoglu, Mehmet Hakan; Hatiboglu, Mustafa Aziz; ÇEŞME, DİLEK HACER; ALKAN, ALPAY; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZ
    Objective: To investigate changes in DTI (Diffusion Tensor Imaging) parameters in brainstem subcortical auditory pathways after Gamma Knife Radiosurgery (GKR) in patients with intracanalicular vestibular schwannoma (ICVS) and to analyze the relationship between tumor volume and ADC (apparent diffusion coefficient) and FA (fractional anisotropy) values. Method: Seventeen patients with ICVS were evaluated before and after GKR. ADC and FA values of the lateral lemniscus (LL) and inferior colliculus (IC) and tumor volume were calculated. Patients who responded to GKR were classified as Group 1 and those who did not respond adequately as Group 2. The relationship between ADC and FA values and changes in tumor volume were analyzed. Results: Tumor volume significantly decreased after GKR. ADC values obtained from the tumor increased after GKR (p:0.002). There was no significant difference in LL and IC before and after GKR in terms of FA and ADC values (n:17). There was a positive correlation between response to treatment and contralateral LL ADC values after GKR (p=0.005, r:0.652). There was a negative correlation between contralateral IC FA values after GKR and response to treatment (p=0.017, r: -0.568). There was a significant difference between Groups 1 and 2 in regards to contralateral LL ADC (p=0.03) and IC FA values (p=0.017). Conclusion: Since the cochlear nerve and subcortical auditory pathways have low regeneration potential after nerve damage, ADC and FA changes in LL and IC may be explained with the presence of intracanalicular tumors prior to GKR. Since GKR does not cause additional damage to the subcortical auditory pathways at the brainstem level, we think that GKR is a noninvasive treatment method that can be used safely in patients with ICVS.