Person: BÜYÜKAYDIN, BANU
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Publication Metadata only Diyabetik hastalarda diyetisyen kontrolü sıklığı bunun hasta memnuniyeti ve kan şeker regülasyonu üzerine etkisi(2011-05-15) KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFA; YOLBAŞ, SERVET; ÇIKRIKÇIOĞLU, MEHMET ALİ; ZORLU, MEHMET; BÜYÜKAYDIN, BANU; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; BÜYÜKAYDIN, BANUPublication Metadata only Diyabetik hastalardaki sigara kullanımı ve kan şekeri regülasyonu ile ilişkisi(2011-05-15) ZORLU, MEHMET; KISKAÇ, MUHARREM; YOLBAŞ, SERVET; ÇAKIRCA, MUSTAFA; BÜYÜKAYDIN, BANU; ZORLU, MEHMET; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFA; BÜYÜKAYDIN, BANUPublication Metadata only Evaluation of the relationship between serum apelin levels and vitamin D and mean platelet volume in diabetic patients(2014-09-01) Buyukaydin, BANU; Zorlu, MEHMET; Cakirca, MUSTAFA; KESGIN, Sidika; YAVUZ, Erdinc; ARDIC, Cuneyt; Camli, AHMET ADİL; CIKRIKCIOGLU, Mehmet Ali; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇAKIRCA, MUSTAFA; KARATOPRAK, CUMALİ; BÜYÜKAYDIN, BANU; ÇAMLI, AHMET ADİLObjectives. - It was reported that Vitamin D deficiency was associated with a greater risk of cardiometabolic diseases, obesity, impaired glucose tolerance and diabetes mellitus type 2, arterial hypertension, and dyslipidemia. Apelin is an adipocytokine suspected to have a role in skeletal muscle glucose utilization and glycemic regulation which may be a promising treatment modality for diabetes. It was recently reported that increased mean platelet volume (MPV) was emerging as an independent risk factor for thromboembolism, stroke, and myocardial infarction. In patients with diabetes, MPV was higher compared with the normal glycemic controls; in addition, it has been proposed that an increase in MPV may play a role in the micro- and macro-vascular complications related to diabetes. We postulated that deficiency in Vitamin D levels might be associated with higher MPV and lower serum apelin levels leading a further increase in insulin resistance in diabetic patients. So, we aimed to investigate Vitamin D levels, MPV and serum apelin levels in diabetic patients and their correlations between each other. Materials and method. - This is a cross-sectional study design. Seventy-eight patients with Diabetes Mellitus type 2, admitted to our outpatient clinic of internal medicine department at Bezmialem Vakif University, were included in our study. Forty-one patients were female; 37 patients were male. Serum apelin levels, fasting glucose levels, urea, creatinine, triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting serum insulin level, HbAl(c), free T3, free T4, TSH, vitamin D (25-OH Vitamin D) and complete blood counts were analyzed in all subjects. Results. - Each sex was analyzed separately. We found that a positive correlation existed between serum apelin levels and BMI in female patients. (r: 0.380, P: 0.014) There was also a significant positive correlation between MPV and HbAl, and fasting glucose levels and a negative correlation between MPV and PLT. (r: 0.377, P: 0.021; r: 0.395, P: 0.014; r: 0.401, P: 0.011; respectively) We failed to show a significant relationship between serum vitamin D levels, serum apelin levels and MPV in patients with diabetes mellitus type 2. Conclusion. - We failed to show an association between vitamin D, apelin and MPV higher volumes of which may have a role in cardiovascular complications related to diabetes by increasing platelet activation. (C) 2014 Published by Elsevier Masson SAS.Publication Metadata only Diyabetik nefropati patogenezinde etkili bir tedavi arayışı Nigella sativa(2014-10-26) KOÇYİĞİT, ABDURRAHİM; BÜYÜKAYDIN, BANU; KAZANCIOĞLU, RUMEYZA; KESGİN, SIDDIKA; SUNGUR, ELİF; ZORLU, MEHMET; KISKAÇ, MUHARREM; BÜYÜKAYDIN, BANU; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only The effect of nigella sativa extract on antioxidant status in streptozotocin induced diabetes mellitus(2015-03-17) KOÇYİĞİT, ABDURRAHİM; KAZANCIOĞLU, RUMEYZA; KESGİN, SIDDIKA; SUNGUR, ELİF; ZORLU, MEHMET; KISKAÇ, MUHARREM; BÜYÜKAYDIN, BANU; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers(2020-07-01T00:00:00Z) GÜLER, Eray Metin; BÜYÜKAYDIN, BANU; Karaaslan, Tahsin; OLGAÇ, ATİLLA; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİM; BÜYÜKAYDIN, BANU; GÜLER, ERAY METİN; OLGAÇ, ATİLLA; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİMBackground: Diabetic polyneuropathy is a very common complication of diabetes. Numerous studies are available in terms of pathogenesis. But examination methods with low reliability are still not standardized and generally time consuming. High-sensitive, easy-to-access methods are expected. Biochemical markers are one of the subjects of research. We aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of neuropathy. Aim: To determine the place and availability of visfatin and thiol-disulfide homeostasis in this disorder. Methods: A total of 392 patients with type 2 diabetes mellitus were included in the study. The polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and examination. The biochemical parameters, oxidative stress markers, visfatin, and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical signs. Results: Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration (P < 0.005). Neuropathy related symptoms were present in 20.7% of the patients, but neuropathy related findings were observed in 43.9% of the patients. Serum glucose, glycated hemoglobin, and visfatin were positively correlated with each other. Also, these parameters were positively correlated with the total oxidative stress index. Total and native thiol was positively correlated with total antioxidant status and negatively with oxidant status. Inversely thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status (P < 0.005). There was no correlation between visfatin and thiol-disulphide (P = 0.092, r = 0.086). However, a significant negative correlation was observed between visfatin and total with native thiol (P < 0.005, r = -0.338), (P < 0.005, r = -0.448). Conclusion: Diagnosis of neuropathy is one of the issues studied in patients with diabetes. Visfatin and thiol-disulfide balance were analyzed for the first time in this study with inspiring results.Publication Metadata only Polikliniğimize başvuran diyabetik hastalarda bitkisel ilaç kulanım sıklığının değerlendirilmesi(2011-05-15) YOLBAŞ, SERVET; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇAKIRCA, MUSTAFA; BÜYÜKAYDIN, BANU; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇAKIRCA, MUSTAFA; BÜYÜKAYDIN, BANUPublication Metadata only The Effect of Nigella Sativa Extract on Glucose Regulation and Renal Parameters in Streptozotocin-Induced Diabetic Rats(2016-07-01) BÜYÜKAYDIN, BANU; Kesgin, Siddiga; Zorlu, MEHMET; Kıskaç, MUHARREM; Koçyiğit, ABDÜRRAHİM; KAZANCIOĞLU, RÜMEYZA; BÜYÜKAYDIN, BANU; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİM; KAZANCIOĞLU, RÜMEYZAPublication Open Access Frequency and determinants of erectile dysfunction in Turkish diabetic men(2015-03-01) Buyukaydin, BANU; KISKAC, MUHARREM; ZORLU, MEHMET; CAKIRCA, MUSTAFA; KARATOPRAK, CUMALİ; YAVUZ, Erdinc; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇAKIRCA, MUSTAFA; BÜYÜKAYDIN, BANU; KARATOPRAK, CUMALİBackground: Erectile dysfunction (ED) or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual performance. ED is observed more frequently and manifests earlier in diabetic patients compared to the normal population. Material and Methods: One hundred and seventeen consecutive male type 2 diabetes patients seen in our Diabetes Outpatient Clinic were included in our study and these patients were evaluated in terms of the presence and duration of ED, treatment and response to treatment of ED, duration of diabetes mellitus, HbA1c levels, and the presence of microalbuminuria, estimated from 24‑hour urine collections. Results: The patients included in our study were divided into three groups: Patients with no ED, mild‑to‑moderate ED, and severe ED. Twenty‑nine patients (24.8%) fell in the no ED group, 28 (23.9%) in the mild‑to‑moderate ED group, and 60 (51.3%) in the severe ED group. There were statistically significant differences between these three groups in terms of age (P = 0.015) and duration of diabetes mellitus (P = 0.03). The groups were similar in terms of microalbuminuria measured from 24‑hour urine collections and HbA1c levels (P = 0.328 and P = 0.905, respectively). Twenty‑three of the 88 patients with ED (26.1%) were on ED treatment and 43.5% of these patients reported benefit from the therapy. Conclusion: Age and duration of diabetes were the main determinants of the presence and severity of ED in male Turkish type 2 diabetic patients. The HbA1c levels were higher in patients with ED, but the differences in levels between the groups did not reach statistical significance.