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BAŞARANOĞLU, METİN

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BAŞARANOĞLU
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Author: Senturk, HAKAN × Author: ŞENTÜRK, HAKAN ×

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    PublicationOpen Access
    From fatty liver to fibrosis: A tale of -second hit-
    (2013-02-28) Basaranoglu, METİN; Basaranoglu, GÖKÇEN; Senturk, HAKAN; BAŞARANOĞLU, METİN; BAŞARANOĞLU, GÖKÇEN; ŞENTÜRK, HAKAN
    Although much is known about how fat accumulates in the liver, much remains unknown about how this causes sustained hepatocellular injury. The consequences of injury are recognized as nonalcoholic steatohepatitis (NASH) and progressive fibrosis. The accumulation of fat within the hepatocytes sensitizes the liver to injury from a variety of causes and the regenerative capacity of a fatty liver is impaired. An additional stressor is sometimes referred to as a “second hit” in a paradigm that identifies the accumulation of fat as the “first hit”. Possible candidates for the second hit include increased oxidative stress, lipid peroxidation and release of toxic products such as malondialdehyde and 4-hydroxynonenal, decreased antioxidants, adipocytokines, transforming growth factor (TGF)-β, Fas ligand, mitochondrial dysfunction, fatty acid oxidation by CYPs (CYP 2E1, 4A10 and 4A14), and peroxisomes, excess iron, small intestinal bacterial overgrowth, and the generation of gut-derived toxins such as lipopolysaccharide and ethanol. Oxidative stress is one of the most popular proposed mechanisms of hepatocellular injury. Previous studies have specifically observed increased plasma and tissue levels of oxidative stress markers and lipid peroxidation products, with reduced hepatic and plasma levels of antioxidants. There is also some indirect evidence of the benefit of antioxidants such as vitamin E, S-adenosylmethionine, betaine, phlebotomy to remove iron, and N-acetylcysteine in NASH. However, a causal relationship or a pathogenic link between NASH and oxidative stress has not been established so far. A number of sources of increased reactive oxygen species production have been established in NASH that include proinflammatory cytokines such as tumor necrosis factor (TNF)-α, iron overload, overburdened and dysfunctional mitochondria, CYPs, and peroxisomes. Briefly, the pathogenesis of NASH is multifactorial and excess intracellular fatty acids, oxidant stress, ATP depletion, and mitochondrial dysfunction are important causes of hepatocellular injury in the steatotic liver.
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    Nonalcoholic fatty liver may increase the risk of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives
    (2016-10-01) Basaranoglu, METİN; CANBAKAN, Billur; YILDIZ, Kemal; CEYLAN, Bahadir; BAYSAL, Birol; Uysal, Omer; Senturk, HAKAN; BAŞARANOĞLU, METİN; UYSAL, ÖMER; ŞENTÜRK, HAKAN
    Fatty liver is a common disease in developed countries. We investigated the frequency of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives.
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    Seasonal clustering in inflammatory bowel disease: a single centre experience
    (2015-06-01) Basaranoglu, METİN; SAYILIR, Abdurrahim; DEMIRBAG, Ali E.; Mathew, Sanju; ALA, Aftab; Senturk, HAKAN; BAŞARANOĞLU, METİN; ŞENTÜRK, HAKAN
    Backgrounds and aims: External stimuli are considered as possible triggers for the onset of inflammatory bowel disease (IBD), and particularly chronic ulcerative colitis (CUC) in genetically susceptible individuals. Our aims were to investigate monthly clustering-patterns in the onset of symptoms and diagnosis of IBD, as well as health seeking behavior in those individuals. Materials and methods: Two hundred and eighty-two consecutive patients with IBD were included. Onset of symptoms (month) and delay to diagnosis were analyzed. Kruskal-Wallis and Roger-s test were used to analyze for statistical patterns in seasonal clustering. Results: There were 181 males and 101 females with IBD; mean age: 40 +/- 14.7 years (median: 38, range: 14-79 years). The peak number of IBD cases was seen in winter/early spring, with the lowest numbers in autumn, which reached statistical significance in the CUC group (p: 0.029). Seasonal changes were not significantly affected by gender. The time delay to diagnosis from symptom onset was 3.0 +/- 2.3 months in males (median: 2, range: 0-12 months) vs 3.2 +/- 3.2 months (median: 2, range: 0-18 months) in females (not statistically significant). Conclusion: Our results show a seasonal relation in IBD cases, particularly in CUC, which may suggest external stimuli acting as a precipitant to IBD in susceptible individuals. There was a delay between symptom onset and CUC diagnosis, which was not felt to be clinically significant.
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    Fatty liver disease might increase the risk of abdominal operation in patients with fatty liver and the prevalence of cancer in first-degree relatives (Retracted article. See vol. 26, pg. 290, 2015)
    (2014-12-01) Basaranoglu, METİN; Canbakan, Billur; YILDIZ, Kemal; CEYLAN, Bahadir; BAYSAL, Birol; Uysal, Omer; Senturk, HAKAN; BAŞARANOĞLU, METİN; UYSAL, ÖMER; ŞENTÜRK, HAKAN
    Background/Aims: We investigated the risk of abdominal operation in patients with fatty liver and the risk of any cancer in first-degree relatives of patients with fatty liver.