Person: ÜNVER, NURCAN
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Publication Metadata only Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases.(2019-04-01) UNVER, NURCAN; COBAN, GANİME; ARıCı, DİLEK SEMA; BUYUKPıNARBASıLı, NUR; Gucin, ZÜHAL; MALYA, FATMA ÜMİT; ONARAN, OI; TOPALAN, K; ÜNVER, NURCAN; ÇOBAN, GANİME; ARICI, DILEK SEMA; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; MALYA, FATMA ÜMİTPublication Metadata only Differential expression of P16 and P21 in benign and malignant uterine smooth muscle tumors(2011-08-01T00:00:00Z) Unver, NURCAN; Acikalin, Mustafa Fuat; Oner, Ulku; Ciftci, Evrim; Ozalp, S. Sinan; Colak, Ertugrul; ÜNVER, NURCANThe diagnosis of benign and malignant uterine smooth muscle tumors depends on morphologic criteria such as nuclear atypia, coagulative tumor cell necrosis and mitotic activity. Most of these tumors are readily classifiable into benign or malignant categories using these criteria. However, the distinction between leiomyomas and leiomyosarcomas may at times be problematic. Hence, it would be useful to have additional markers which could help to distinguish these tumors. The aim of the study was to evaluate p16 and p21 expressions in uterine smooth muscle tumors and determine whether p16 and p21 have a potential value in the differential diagnosis of problematic cases. In addition, we evaluated whether the differential expression of p16 and p21 in uterine leiomyosarcomas correlated with tumor recurrence and patient survival.Publication Metadata only Relationship between the poor glycemic control and risk factors, life style and complications.(2017-01-01T00:00:00Z) KAYAR, Yusuf; ILHAN, Aysegul; KAYAR, Nuket Bayram; Unver, NURCAN; Coban, GANİME; EKINCI, Iskender; HAMDARD, Jamsid; PAMUKCU, Ozgul; EROGLU, Hatice; ÜNVER, NURCAN; ÇOBAN, GANİMEIt has shown that the decrease of blood glucose levels in patient with diabetes mellitus decreases mortality and morbidity rates. Main purpose in diabetes is to achieve and prevent the glycemic control. We aimed to evaluate the relationship between poor glycemic control and metabolic parameters, individual life and complications. Seven hundred fifty seven patients with type II diabetes mellitus have evaluated with demographical characteristic, body mass index, abdominal circumferences, blood pressures, dietary compliances, physical exercise statuses and laboratory analysis; and the relationship of these parameteres were investigated. Poor glycemic control was found significantly associated with duration of diabetes, age of onset, family history, job status, educational status, antidiabetic drugs, body mass index, abdominal circumference, hypertension, lipid and fasting plasma glucose levels. There was a significant relationship between the glycemic control and dietary compliance, physical activity, self blood glucose monitoring and drug compliance. While there is a significant relationship between the poor glycemic control and nephropathy, retinopathy, neuropathy and cardiovascular diseases; no significant relationship was seen in the cerebrovascular diseases and arthropathy. We have pointed the relationship of glycemic control with sociodemographic, medical status, life style, lipid levels and complications. Better results can be obtained by eliminating the factors related to poor glycemic control.Publication Metadata only Spinal cord ischemia after endoscopic ultrasound guided celiac plexus neurolysis: case report and review of the literature(2017-01-01) Koker, Ibrahim Hakki; Aralasmak, AYŞE; Unver, NURCAN; Asil, TALİP; Senturk, HAKAN; KÖKER, İBRAHİM HAKKI; ARALAŞMAK, AYŞE; ÜNVER, NURCAN; ASİL, TALIP; ŞENTÜRK, HAKANIntroduction: Endosonography guided celiac plexus neurolysis is efficacious in the management of severe pain due to advanced pancreatic cancer. Although endoscopic ultrasound (EUS) guided celiac neurolysis (CN) is mostly a safer procedure than the percutaneous posterior approach, severe complications such as paraplegia have been reported.Publication Metadata only Biphasic malignant mesothelioma of the testis: Case report.(2017-03-01) ARMAĞAN, ABDULLAH; ÇOBAN, GANİME; ÜNVER, NURCAN; KIZILTAN, HURİYE ŞENAY; GÜCİN, ZÜHAL; ÇOBAN, GANİME; ÜNVER, NURCAN; KIZILTAN, HURİYE ŞENAYPublication Metadata only EUS-guided FNA of a portal vein thrombus in hepatocellular carcinoma(2015-06-01T00:00:00Z) Kayar, Yusuf; Turkdogan, Kenan Ahmet; Baysal, Birol; ÜNVER, NURCAN; Danalioglu, Ahmet; ŞENTÜRK, HAKAN; ÜNVER, NURCAN; ŞENTÜRK, HAKANPortal vein thrombosis is a relatively rare but well-known complication of cirrhosis that has a prevalence of between 1% and 5.7%. On the contrary, in case of hepatocellular carcinoma (HCC), it is a much more frequent complication. In this paper, we presented three cases that had liver cirrhosis, mass and portal vein thrombosis in liver. We were not able to diagnose the cases through imaging methods, laboratory results or histopathologically, however, they were diagnosed with endoscopic ultrasonography-fine needle aspiration EUS-FNA from portal vein thrombus.Publication Metadata only Evaluation of solid pseudopapillary tumor of the pancreas: One tertiary center experience(2018-01-01) KAYAR, Yusuf; Unver, NURCAN; ÇOBAN, GANİME; GÜCİN, ZÜHAL; EKINCI, Iskender; EMEGIL, Sebnem; KAYAR, Nuket Bayram; BAYSAL, Birol; BUGDACI, Mehmet Sait; ŞENTÜRK, HAKAN; ÜNVER, NURCAN; ÇOBAN, GANİME; GÜCİN, ZÜHAL; ŞENTÜRK, HAKANPublication Metadata only Clinical evaluation of simultaneous integrated boost in brain metastasis patients with helical intensity modulated radiotherapy(2018-04-01) KIZILTAN, HURİYE ŞENAY; ERIS, A.H.; MERAL, İSMAİL; SEYITHANOGLU, H.; DÜNDAR, TOLGA TURAN; EREN, F.; UNVER, NURCAN; AYDIN, TEOMAN; MAYADAĞLI, ALPASLAN; BAYIR, A.G.; CELIKTEN, M.; KIZILTAN, HURİYE ŞENAY; MERAL, İSMAİL; DÜNDAR, TOLGA TURAN; TEKÇE, ERTUĞRUL; ÜNVER, NURCAN; AYDIN, TEOMAN; MAYADAĞLI, ALPASLANBackground: This study was performed to assess patient survival and treatment toxicity after helical tomotherapy (HT) with simultaneous integrated boost (SIB) radiotherapy (RT) for cancer patients with one to eight brain metastases (BM) who have been treated with or without surgery. Materials and Methods: A total of 48 brain metastasis (BM) patients were included in this retrospective study between April 2015 and December 2016,. The patients were treated with image-guided intensity modulated radiation therapy (IMRT) on the helical tomotherapy (HT) machine. Whole brain HT as 25 Gy and SIB to metastasis sites as 35 Gy was delivered in 10 fractions. The patient were aged between 50 to 80 years old, volume of the BM was between 6 to 75 cc and the number of brain metastasis was between 1 to 8, Karnofsky Performance Score (KPS) ranged between 50-90 and RPA I-III. Surgery was performed to two patients before RT. The maximum patient follow-up time was 20 months. Results: The primary neurotoxicity observed in patients was grade I- II brain edema related headache and lethargy. In patients who had survived 3- 12 months, KPS improved median score of 20 points and RPA was grade I after six months. Twelve patients had passed away at the end of a 20- month follow-up. Conclusion: HT utilizing SIB treatment for 1- 8 BM was achieved successfully with no significant toxicity. An improvement of performance status indicators of patients following RT was observed.Publication Metadata only A study on the effects of insufflation gases employed in laparoscopy on various organs: a rat model(2018-09-28T00:00:00Z) MIRAPOGLU, SEMIH L.; YILDIRIM, DOĞAN; ŞAHİN, KAMİL; SARAC, FATMA; AYDOĞDU, İBRAHİM; HUT, ADNAN; ÇAKIR, MİKAİL; DÖNMEZ, TURGUT; ÇOBAN, GANİME; ÜNVER, NURCAN; ÖZER, ÖMER FARUK; ÇAY, ALİ; AYDOĞDU, İBRAHİM; ÇOBAN, GANİME; ÜNVER, NURCAN; ÖZER, ÖMER FARUK; ÇAY, ALIPublication Metadata only Peri-operative radiotherapy for the prevention of post -operative fibrosis on rats(2018-10-01) KIZILTAN, HURİYE ŞENAY; ERIS, ALİ HİKMET; MERAL, İSMAİL; SEYİTHANOĞLU, HAKAN; DÜNDAR, TOLGA TURAN; EREN, FATMA; ÜNVER, NURCAN; AYDIN, TEOMAN; MAYADAGLı, ALPASLAN; KIZILTAN, HURİYE ŞENAY; ERİŞ, ALİ HİKMET; MERAL, İSMAİL; SEYİTHANOĞLU, MEHMET HAKAN; DÜNDAR, TOLGA TURAN; ÜNVER, NURCAN; AYDIN, TEOMAN; MAYADAĞLI, ALPASLANBackground: Post-operative fibrosis related pains and functional anomalies can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats. Materials and Methods: Twenty three male Wistar albino rats, were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group in addition to this procedure also received ped-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats. Results: The results have indicated statistically significant (P<0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups. Conclusion: It was concluded that ped-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation.