Person: GÜCİN, ZÜHAL
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Publication Metadata only Fibrolamellar hepatocellular carcinoma presenting with early recurrent thrombosis(2022-01-01) KUNDAKÇIOĞLU H.; Destek S.; GÜCİN Z.; Değer K. C.; KUNDAKÇIOĞLU, HACER; GÜCİN, ZÜHAL; DEĞER, KAMURAN CUMHURPublication Metadata only Stem cell markers: A guide to neoadjuvant therapy in breast carcinomas(2022-06-01T00:00:00Z) Gücin, Zühal; Büyükpınarbaşılı, Nur; Geçer, Melin; Ersoy, Yeliz Emine; Türk, Hacı Mehmet; Yıldız, Şeyma; Aksoy, Direnç Özlem; GÜCİN, ZÜHAL; GEÇER, MELİN; ERSOY, YELIZ EMINE; TÜRK, HACI MEHMET; YILDIZ, ŞEYMABACKGROUND: In recent years, stem cells have been defined as the main cell population responsible for resistance to anticancer therapies. AIM: This study aims to investigate potential associations between the stem cell population and the degree of tumor regression in breast carcinomas treated with neoadjuvant therapy. SETTINGS AND DESIGN: The study included 92 patients with breast carcinoma who received neoadjuvant therapy. Tumor regression was defined based on Miller and Payne grading system. Patients with grade 1 or 2 regression on a 5‑point scale were included in group 1 (n = 37), grade 3 regression in group 2 (n = 32), and grade 4 or 5 regression in group 3 (n = 23). MATERIALS AND METHODS: Immunohistochemical staining was performed on paraffin block sections of every case using CD44, CD24, CD29, CD133, ID4, and ALDH1 antibodies to detect stem cells. STATISTICAL ANALYSIS USED: IBM Statistical Package for the Social Sciences (SPSS), version 23.0 (IBM Corp., Armonk, NY, USA) software was used for statistical analyses, and a P value less than 0.05 was considered statistically significant. RESULTS: Histologically high‑grade tumors are more common in the near‑complete/complete response group (P = 0.004). HER2‑positive tumors were more common in the complete/ near‑complete response group (P = 0.054). Tumor cells positive for stem cell markers CD44 and CD24 were more common in the poor response group (P = 0.027 and P = 0.001, respectively). CD29 expression was reduced in the posttreatment residual tumor tissue in the near‑complete/complete response group. CONCLUSION: High CD44 and CD24 expression may be a predictor of poor response/nonresponse to neoadjuvant therapy in breast carcinomas. KEY WORDS: Breast Cancers, neoadjuvant treatment, stem cell markers, stem cells, tumor regression gradePublication Metadata only A rare co-existence of helicobacter pylori, candida albicans and candida keyfr in a giant gastric ulcer(2014-08-01) Ince, ALİ TÜZÜN; KOCAMAN, Orhan; ISMAILOVA, Medina; TOZLU, Mukaddes; Gucin, ZÜHAL; IRAZ, Meryem; İNCE, ALİ TÜZÜN; GÜCİN, ZÜHALPublication Metadata only EFFECT OF STAT3 STATUS ON RAS & RAF MUTATION IN PATIENTS WITH METASTATIC COLON CARCINOMA(2023-10-29) Geçer M.; Turna S.; Gül B.; Gücin Z.; GEÇER, MELİN; TURNA, SEVAL; GÜL, BURCU; GÜCİN, ZÜHALPublication Metadata only The Relationship of Prognostic Factors with Regulatory T Cells in Langerhans Cell Histiocytosis(2023-12-01) Çoban G.; Coşanay Tekden B.; Güler B.; Çakır F. B.; Toluk Ö.; Gücin Z.; Elagöz Ş.; ÇOBAN, GANİME; COŞANAY TEKDEN, BÜŞRA; GÜLER, BERIL; ÇAKIR, FATMA BETÜL; GÜCİN, ZÜHAL; ELAGÖZ, ŞAHANDEPublication Metadata only The role of intraoperative consultation in the management of ovarian masses and endometrial carcinomas: a 7-year experience(2024-02-01) Şahin N.; Coşanay Tekden B.; Çoban G.; Kıran G.; Arıcı D. S.; Toluk Ö.; Gücin Z.; ŞAHİN, NURHAN; COŞANAY TEKDEN, BÜŞRA; ÇOBAN, GANİME; KIRAN, GÜRKAN; TOLUK, ÖZLEM; GÜCİN, ZÜHAL