Person: GÜCİN, ZÜHAL
71 results
Search Results
Now showing 1 - 10 of 71
Publication Metadata only Travmaya bağlı pankreas tümörü rüptürü(2015-10-31) MIRAPOGLU, S. L.; AYDOĞDU, İBRAHİM; GÜCİN, ZÜHAL; YILMAZ, TF; UMUTOGLU, T; KILINCASLAN, H.; AYDOĞDU, İBRAHİM; GÜCİN, ZÜHALPublication Metadata only ELECTRICAL IMPEDANCE ANALYSIS OF BIOPSY SPECIMENS TO DISTINGUISH HEALTHY AND CANCEROUS BREAST TISSUES(2013-01-01T00:00:00Z) Okkesim, Sukru; Yildirim, Imran; Gucin, ZÜHAL; HASBAHCECI, Mustafa; MUSLUMANOGLU, Mahmut; GÜCİN, ZÜHALOne of the most common cancer types in the world is breast cancer. Screening and diagnostic methods like mammography, ultrasound or magnetic resonance imaging are not enough for all clinical situations to conclude about the exact nature of the lesions found in the breast tissue. Therefore, physicians need biopsy as an invasive procedure. The aim of this study was to investigate the electrical impedance of abnormal and normal breast tissue, in order to find a new method, for reliable, non-invasive detection of breast cancer. For this purpose, breast tissues taken from five patients were provided Bezmialem Vakif University Faculty of Medicine Department of General Surgery, and impedance measurements have been done at the Pathology Department of the same university. Impedances of healthy and tumoral tissues for each patient were measured. Analysis of impedance values has shown significant difference between healthy and tumoral tissuesPublication Metadata only Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases.(2019-04-01) UNVER, NURCAN; COBAN, GANİME; ARıCı, DİLEK SEMA; BUYUKPıNARBASıLı, NUR; Gucin, ZÜHAL; MALYA, FATMA ÜMİT; ONARAN, OI; TOPALAN, K; ÜNVER, NURCAN; ÇOBAN, GANİME; ARICI, DILEK SEMA; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; MALYA, FATMA ÜMİTPublication Metadata only p53 expression and relationship with MDM2 amplification in breast carcinomas(2016-04-01) Buyukpinarbasili, NUR; Gucin, ZÜHAL; Ersoy, YELİZ EMİNE; ILBAK, Ayca; Kadioglu, HÜSEYİN; Muslumanoglu, Mahmut; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; ERSOY, YELIZ EMINE; KADIOĞLU, HÜSEYİNCarcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation domain of p53. The loss of MDM2 function on p53 regulation results in deprivation of p53 tumor suppressor ability. Single nucleotide polymorphisms (SNP309 T->G exchange) or MDM2 amplification has been proposed to play a role in this issue. In the present study, our aim is to analyze p53 and MDM2 status and investigate their interactions in human sporadic breast carcinoma. The study groups were separated according to their molecular classifications. In each group, histologic type of the tumor, conventional prognostic parameters, p53, and MDM2 interactions were compared statistically. Tumors are divided into 4 subtypes due to estrogen and progesterone receptor status, HER-2, and Ki-67 proliferation index results. According to this classification, 23 cases are in the luminal A, 32 cases are in the luminal B, 15 cases are in the HER-2 positive, and 22 cases are in the triple-negative group, with a total of 92 cases. p53 expression is low in luminal breast carcinomas than HER-2 and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total. MDM2 gene amplification does not have a significant role in breast carcinogenesis, but other possible mechanisms may play a role in its inactivation. (C) 2016 Elsevier Inc. All rights reserved.Publication Metadata only Assessment of multifocality and axillary nodal involvement in early-stage breast cancer patients using 18F-FDG PET/CT compared to contrast-enhanced and diffusion-weighted magnetic resonance imaging and sentinel node biopsy(2015-08-01) ERGÜL, Nurhan; Kadioglu, HÜSEYİN; Yildiz, Seyma; YUCEL, Serap Baskaya; Gucin, ZÜHAL; Erdogan, EZGİ BAŞAK; Aydin, MEHMET; MUSLUMANOGLU, Mahmut; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; ERDOĞAN, EZGİ BAŞAK; AYDIN, MEHMETBackground: Non-invasive evaluation of the extent of axillary nodal involvement in early-stage breast cancer (ESBC) patients and accurate assessment of multifocality are both challenging. Few reports have explored whether 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) might be more useful than other diagnostic methods in these contexts.Publication Metadata only Skin Recurrence of a Phylloides Tumor and Impacy of Radiotherapy A Case Report and Review of The Literature(2013-01-01) YÜCEL, SERAP; KADIOĞLU, HÜSEYİN; GÜRAL, ZEYNEP; YILDIZ, ŞEYMA; YILDIZ, ŞEYMA; GÜCİN, ZÜHALPublication Metadata only Primer Meme Lenfoması; Yineleyen Hastalık,(2012-05-01) KADIOGLU, HÜSEYİN; YUCEL, SERAP BASKAYA; GÜRAL, ZEYNEP; GÖZÜBÜYÜKOGLU, NURHAN; AKGÜN, ZÜLEYHA; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMAN; ERSOY, YELİZ EMİNE; SAGLAM, ESRA KAYTAN; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMANPublication Metadata only İNFLAMATUAR MEME KANSERİ ŞEKLİNDE PREZENTE OLAN MÜSİNÖZ MEME KANSERİ OLGUSU(2015-08-01) YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; ERDOĞAN, EZGİ BAŞAK; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; ERDOĞAN, EZGİ BAŞAK; KADIOĞLU, HÜSEYİNPublication Metadata only Fibrolamellar hepatocellular carcinoma presenting with early recurrent thrombosis(2022-01-01) KUNDAKÇIOĞLU H.; Destek S.; GÜCİN Z.; Değer K. C.; KUNDAKÇIOĞLU, HACER; GÜCİN, ZÜHAL; DEĞER, KAMURAN CUMHURPublication Metadata only Current Approach to the Prognostic Parameters of Testicular Germ Cell tumors Accompanied by Our Cases(2020-08-01T00:00:00Z) Çoban, Ganime; Yıldız, Pelin; Sezal, Zeynep; Adıllı, Adile; Beşiroğlu, Mehmet; Akçay, Muzaffer; Gücin, Zühal; ÇOBAN, GANİME; YILDIZ, PELİN; BEŞİROĞLU, MEHMET; AKÇAY, MUZAFFER; GÜCİN, ZÜHAL