Person: GÜCİN, ZÜHAL
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Publication Metadata only p53 expression and relationship with MDM2 amplification in breast carcinomas(2016-04-01) Buyukpinarbasili, NUR; Gucin, ZÜHAL; Ersoy, YELİZ EMİNE; ILBAK, Ayca; Kadioglu, HÜSEYİN; Muslumanoglu, Mahmut; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; ERSOY, YELIZ EMINE; KADIOĞLU, HÜSEYİNCarcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation domain of p53. The loss of MDM2 function on p53 regulation results in deprivation of p53 tumor suppressor ability. Single nucleotide polymorphisms (SNP309 T->G exchange) or MDM2 amplification has been proposed to play a role in this issue. In the present study, our aim is to analyze p53 and MDM2 status and investigate their interactions in human sporadic breast carcinoma. The study groups were separated according to their molecular classifications. In each group, histologic type of the tumor, conventional prognostic parameters, p53, and MDM2 interactions were compared statistically. Tumors are divided into 4 subtypes due to estrogen and progesterone receptor status, HER-2, and Ki-67 proliferation index results. According to this classification, 23 cases are in the luminal A, 32 cases are in the luminal B, 15 cases are in the HER-2 positive, and 22 cases are in the triple-negative group, with a total of 92 cases. p53 expression is low in luminal breast carcinomas than HER-2 and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total. MDM2 gene amplification does not have a significant role in breast carcinogenesis, but other possible mechanisms may play a role in its inactivation. (C) 2016 Elsevier Inc. All rights reserved.Publication Metadata only Comment on: Actinomycotic Infection of the Abdominal Wall Mimicking a Malignant Neoplasm by Yi et al.(2012-12-01) Kadioglu, HÜSEYİN; Ersoy, YELİZ EMİNE; Bozkurt, SÜLEYMAN; Memmi, NAİM; CIPE, Gokhan; Gucin, ZÜHAL; MUSLUMANOGLU, Mahmut; KADIOĞLU, HÜSEYİN; ERSOY, YELIZ EMINE; BOZKURT, SÜLEYMAN; MEMMİ, NAİM; GÜCİN, ZÜHALPublication Metadata only The role of miRNAs as a predictor of multicentricity in breast cancer.(2019-02-01) AKBULUT, H; ERSOY, YELİZ EMİNE; COŞKUNPINAR, E; GÜCİN, ZÜHAL; YILDIZ, S; MALYA, FATMA ÜMİT; HASTÜRK, B; MUSLUMANOGLU, MAHMUT; ERSOY, YELIZ EMINE; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; MALYA, FATMA ÜMİTExpression profiles of miRNAs are shown to be different in various cancers to regulate expression of mRNA or to have a role in inhibition of translation, thus it shows the possible effect in progression, invasion and metastasis of breast cancer cells. The effect of breast conserving treatment in local recurrence and survival rates for the patients who have multicentric breast cancer is still controversial. In our study, we intended to evaluate the foresight of 84 miRNAs which are identified in breast cancer for having differentiated expressions. Thirty-one patients with unifocal and 26 patients with multicentric breast cancer were included in this study. These tissue samples of both malignant and normal breast tissues were kept in RNA later solution at -80 degrees C. Eighty-four miRNAs were studied with miScript miRNA PCR Array Human Breast Cancer kit. Fold change, cut off value was accepted as four. In unifocal group, there were 13 upregulated and five downregulated miRNAs and in multicentric group, there were three upregulated and seven downregulated miRNAs. To reach better results for breast cancer diagnosis and treatment, it is important to enlighten tumor biology, and pay attention to target and individual therapy. Thus, miRNAs have potential role in identifying tumor characteristics in supporting diagnosis and resulting with better evaluated disease for better treatment results with individual strategies.Publication Metadata only Primary breast lymphoma; disease recurrence Primer meme lenfomasi{dotless}; yineleyen hastali{dotless}k(2012-09-18) Kadioǧlu, HÜSEYİN; YUCEL, Serap; GÜRAL, Zeynep; GÖZÜBÜYÜKOGLU, Nurhan; AKGÜN, Züleyha; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; Bozkurt, SÜLEYMAN; ERSOY, YELİZ EMİNE; MUSLUMANOGLU, Mahmut; SAGLAM, Esra Kaytan; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMAN; ERSOY, YELIZ EMINEPublication Metadata only Stem cell markers: A guide to neoadjuvant therapy in breast carcinomas(2022-06-01T00:00:00Z) Gücin, Zühal; Büyükpınarbaşılı, Nur; Geçer, Melin; Ersoy, Yeliz Emine; Türk, Hacı Mehmet; Yıldız, Şeyma; Aksoy, Direnç Özlem; GÜCİN, ZÜHAL; GEÇER, MELİN; ERSOY, YELIZ EMINE; TÜRK, HACI MEHMET; YILDIZ, ŞEYMABACKGROUND: In recent years, stem cells have been defined as the main cell population responsible for resistance to anticancer therapies. AIM: This study aims to investigate potential associations between the stem cell population and the degree of tumor regression in breast carcinomas treated with neoadjuvant therapy. SETTINGS AND DESIGN: The study included 92 patients with breast carcinoma who received neoadjuvant therapy. Tumor regression was defined based on Miller and Payne grading system. Patients with grade 1 or 2 regression on a 5‑point scale were included in group 1 (n = 37), grade 3 regression in group 2 (n = 32), and grade 4 or 5 regression in group 3 (n = 23). MATERIALS AND METHODS: Immunohistochemical staining was performed on paraffin block sections of every case using CD44, CD24, CD29, CD133, ID4, and ALDH1 antibodies to detect stem cells. STATISTICAL ANALYSIS USED: IBM Statistical Package for the Social Sciences (SPSS), version 23.0 (IBM Corp., Armonk, NY, USA) software was used for statistical analyses, and a P value less than 0.05 was considered statistically significant. RESULTS: Histologically high‑grade tumors are more common in the near‑complete/complete response group (P = 0.004). HER2‑positive tumors were more common in the complete/ near‑complete response group (P = 0.054). Tumor cells positive for stem cell markers CD44 and CD24 were more common in the poor response group (P = 0.027 and P = 0.001, respectively). CD29 expression was reduced in the posttreatment residual tumor tissue in the near‑complete/complete response group. CONCLUSION: High CD44 and CD24 expression may be a predictor of poor response/nonresponse to neoadjuvant therapy in breast carcinomas. KEY WORDS: Breast Cancers, neoadjuvant treatment, stem cell markers, stem cells, tumor regression gradePublication Metadata only Downregulation of SCARA5 may contribute to breast cancer via promoter hypermethylation.(2018-10-05) ULKER, D; ERSOY, YELİZ EMİNE; Gucin, ZÜHAL; MUSLUMANOGLU, M; BUYRU, N; ERSOY, YELIZ EMINE; GÜCİN, ZÜHALPublication Metadata only Memenin papiller lezyonlarının karakterizayonunda kontrastlı meme MR i ve DAG in karşılaştırılması(2014-11-16) YILDIZ, ŞEYMA; TOPRAK, HÜSEYİN; ARALAŞMAK, AYŞE; ERSOY, YELİZ EMİNE; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; TOPRAK, HÜSEYİN; ARALAŞMAK, AYŞE; ERSOY, YELIZ EMINE; GÜCİN, ZÜHALPublication Metadata only New thyroid fine needle aspiration biopsy needle. Prospective, randomized, clinical study.(2014-07-15T00:00:00Z) Aysan, E; Ersoy, YELİZ EMİNE; Cengiz, M; Akbulut, H; Arici, S; Muslumanoglu, M; ERSOY, YELIZ EMINE; GÜCİN, ZÜHALPublication Metadata only Breast Metastasis of Alveolar Soft Part Sarcoma(2016-10-01) AKBULUT, HÜSEYİN; BEKTAŞOĞLU, Hüseyin; BAŞKÖY, LÜTFULLAH; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; GÜCİN, ZÜHAL; ERSOY, YELİZ EMİNE; AKBULUT, HÜSEYİN; BAŞKÖY, LÜTFULLAH; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; GÜCİN, ZÜHAL; ERSOY, YELIZ EMINEPublication Metadata only Contribution of diffusion-weighted imaging to dynamic contrast-enhanced MRI in the characterization of papillary breast lesions(2018-03-01T00:00:00Z) YILDIZ, ŞEYMA; TOPRAK, HÜSEYİN; ERSOY, YELİZ EMİNE; MALYA, Fatma Ümit; Bakan, Ayse Ahsen; Aralasmak, Ayse; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; TOPRAK, HÜSEYİN; ERSOY, YELIZ EMINE; MALYA, FATMA ÜMİT; ARALAŞMAK, AYŞE; GÜCİN, ZÜHALPapillary lesions have a broad spectrum of appearances on magnetic resonance imaging (MRI). The purpose of this study was to evaluate whether apparent diffusion coefficient (ADC) values of papillary lesions can be used to characterize lesion as benign or malignant. This retrospective study included 29 papillary lesions. Diagnostic values of dynamic contrast-enhanced MRI (DCE-MRI), DWI-ADC, and DCE-MRI plus DWI-ADC were separately calculated. The malignant papillary lesions (0.744x10(-3)mm(2)/s) exhibited significantly lower mean ADC values than the benign lesions (1.339x10(-3)mm(2)/s). Addition of DWI to standard DCE-MRI provided 100% sensitivity. We hypothesized that this combination may prevent unnecessary excisional biopsies.